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tert-Butanol

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tert-Butanol Basic information
tert-Butanol Chemical Properties
  • Melting point:23-26 °C(lit.)
  • Boiling point:83 °C(lit.)
  • Density 0.81 g/mL at 25 °C(lit.)
  • vapor density 2.55 (vs air)
  • vapor pressure 31 mm Hg ( 20 °C)
  • refractive index n20/D 1.399(lit.)
  • Flash point:95 °F
  • storage temp. 2-8°C
  • solubility water: miscible
  • pka19(at 25℃)
  • form Liquid After Melting
  • color APHA: ≤20
  • OdorCharacteristic; camphor-like; pungent.
  • PH Range7
  • Relative polarity0.389
  • Odor Threshold4.5ppm
  • explosive limit2.3-8.0%(V)
  • Water Solubility soluble
  • λmaxλ: 215 nm Amax: 1.00
    λ: 230 nm Amax: 0.50
    λ: 250 nm Amax: 0.20
    λ: 300-350 nm Amax: 0.01
  • JECFA Number85
  • Merck 14,1542
  • BRN 906698
  • Henry's Law Constant1.22 at 25 °C (static headspace-GC, Merk and Riederer, 1997)
  • Exposure limitsTLV-TWA 300 mg/m3 (100 ppm) (ACGIH); IDLH 8000 ppm.
  • Stability:Stable. Very flammable. Incompatible with strong oxidizing agents, copper, copper alloys, alkali metals, aluminium.
  • InChIKeyDKGAVHZHDRPRBM-UHFFFAOYSA-N
  • CAS DataBase Reference75-65-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceEthanol, 1,1-dimethyl-(75-65-0)
  • EPA Substance Registry Systemtert-Butanol (75-65-0)
Safety Information
MSDS
tert-Butanol Usage And Synthesis
  • Chemical PropertiesButyl alcohol, also known as butanol, exists in three isomeric alcohols that are toxic and soluble in most organic liquids.
    n-butyl alcohol, CH3(CH2)2CH20H, also known as l-butanol, propyl carbinol, and prim-butyl alcohol, is a colorless liquid. It is used in manufacturing perfumes and lacquers.
    sec-butyl alcohol, CH3CH2CHOHCH3, also known as 2-butanol, ethyl-methyl carbinol, butylene hydrate, and 2-hydroxy butane, is a colorless liquid. It is used in the preparation of fruit essence.
    tert-butyl alcohol, (CH3)3COH, also known as tert-Butanol, is a white crystalline solid or colorless liquid (above 77 °F) with a camphor-like odor (IPCS, 1987a; NIOSH, 2005). It is soluble in water and miscible with alcohol, ether, and other organic solvents (IPCS, 1987a). It is highly flammable and easily ignited by heat, sparks, or flames; vapors may form explosive mixtures with air. Fire and explosion may result from contact with oxidizing agents, strong mineral acids, or strong hydrochloric acid (NIOSH,1992).
  • Physical propertiestert-Butanol is a colorless liquid or crystals with a camphor-like odor. A detection odor threshold concentration of 2,900 mg/m3 (957 ppmv) was experimentally determined by Dravnieks (1974). In a later study, Nagata and Takeuchi (1990) reported an odor threshold concentration 220 ppbv.
  • Usestert-Butyl alcohol is used as a solvent (e.g., for paints, lacquers, and varnishes); as a denaturant for ethanol and several other alcohols; as an octane booster in gasoline; as a dehydrating agent; as a chemical intermediate in the manufacturing of methyl methacrylate; and in the manufacturing of flotation agents, fruit essences, and perfumes.
  • Usestert-Butyl alcohol is used in the production of tert-butyl chloride, tert-butyl phenol, andisobutylene; in the preparation of artificial musk; and in denatured alcohols.
  • Definitionbutanol: Either of two aliphaticalcohols with the formula C4H9OH.Butan-1-ol, CH3(CH2)3OH, is aprimary alcohol; r.d. 0.81; m.p.–89.5°C; b.p. 117.3°C. Butan-2-ol,CH3CH(OH)C2H5, is a secondary alcohol;r.d. 0.81; m.p. –114.7°C; b.p.100°C. Both are colourless volatileliquids obtained from butane and areused as solvents.
  • Production Methodst-Butyl alcohol is produced as a by-product from the isobutane oxidation process for manufacturing propylene oxide. t-Butyl alcohol is also produced by the acidcatalyzed hydration of isobutylene, a process no longer used in the United States.
  • General DescriptionColorless oily liquid with a sharp alcohol odor. Floats and mixes with water. Produces irritating vapor. Freezing point is 78°F.
  • Air & Water ReactionsHighly flammable. Water soluble.
  • Reactivity ProfileAttacks plastics. [Handling Chemicals Safely 1980. p. 236]. Acetyl bromide reacts violently with alcohols or water [Merck 11th ed. 1989]. Mixtures of alcohols with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. Example: an explosion will occur if dimethylbenzylcarbinol is added to 90% hydrogen peroxide then acidified with concentrated sulfuric acid. Mixtures of ethyl alcohol with concentrated hydrogen peroxide form powerful explosives. Mixtures of hydrogen peroxide and 1-phenylm-2-methyl propyl alcohol tend to explode if acidified with 70% sulfuric acid [Chem. Eng. News 45(43):73 1967; J, Org. Chem. 28:1893 1963]. Alkyl hypochlorites are violently explosive. They are readily obtained by reacting hypochlorous acid and alcohols either in aqueous solution or mixed aqueous-carbon tetrachloride solutions. Chlorine plus alcohols would similarly yield alkyl hypochlorites. They decompose in the cold and explode on exposure to sunlight or heat. Tertiary hypochlorites are less unstable than secondary or primary hypochlorites [NFPA 491 M 1991]. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer 1969].
  • HazardIrritant to eyes and skin. Flammable, dan- gerous fire risk. Central nervous system impair- ment. Questionable carcinogen.
  • Health Hazardtert-Butyl alcohol is more toxic than secbutylalcohol but less toxic than the primaryalcohol. However, its narcotic actionis stronger than that of n-butanol. Inhalationmay cause drowsiness and mild irritationof the skin and eyes. Ingestion may produceheadache, dizziness, and dry skin.
    Acute oral LD50 value (rats): 3500 mg/kg.
  • Chemical ReactivityReactivity with Water: No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
  • Safety ProfileModerately toxic by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Dangerous fire hazard when exposed to heat or flame. Moderately explosive in the form of vapor when exposed to flame. Ignites on contact with potassium-sodum alloys. To fight fire, use alcohol foam, CO2, dry chemical. Incompatible with oxidizing materials, H202. See also n-BUTYL ALCOHOL and ALCOHOLS.
  • Potential ExposureButyl alcohols are used as solvents for paints, lacquers, varnishes, natural and synthetic resins, gums, vegetable oils, dyes, camphor, and alkaloids. They are also used as an intermediate in the manufacture of pharmaceuticals and chemicals; in the manufacture of artificial leather, safety glass; rubber and plastic cements, shellac, raincoats, photographic films, perfumes; and in plastic fabrication.
  • CarcinogenicityThere were increased incidences of renal tubule adenoma and carcinoma in male rats, transitional epithelia hyperplasia of the kidney in male and female rats, follicular cell adenoma of the thyroid in female mice, and follicular cell hyperplasia of the thyroid and inflammation and hyperplasia of the urinary bladder in male and female mice. In addition, a slight increase in follicular cell adenoma or carcinoma of the thyroid (combined) in male mice may have been related to exposure to t-butyl alcohol. t-Butyl alcohol was inactive on mouse skin as a complete carcinogen or as a tumor promoter.
  • SourceDetected in a distilled water-soluble fraction of 94 octane unleaded gasoline at a concentration of 3.72 mg/L (Potter, 1996)
  • Environmental FateBiological. Bridié et al. (1979) reported BOD and COD values of 0.02 and 2.49 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. The ThOD for tert-butyl alcohol is 2.59 g/g. In activated sludge inoculum, 98.5% COD removal was achieved. The average rate of biodegradation was 30.0 mg COD/g?h (Pitter, 1976).
    Bradley et al. (1999) studied the degradation of tert-butyl alcohol by indigenous microorganisms in stream-bed sediments from underground gasoline spill sites in Laurens, SC (Laurens) and Charleston, SC (Oasis). Under aerobic conditions, the amount of tert-butyl alcohol mineralizing to carbon dioxide after 27 d was 70% in both Laurens and Oasis sediments. After 80 d, the amount of mineralization reached an asymptiotic level of approximately 84%. No mineralization of tert-butyl alcohol was observed under strictly anaerobic conditions.
    Photolytic. Wallington (1988c) reported a rate constant of 1.07 x 10-12 cm3/molecule?sec at 298 K. Based on an atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported half-life of tert-butyl alcohol is 8.6 d (Grosjean, 1997).
    Chemical/Physical. May react with strong mineral acids (e.g., hydrochloric) or oxidizers releasing isobutylene (NIOSH, 1997).
    tert-Butyl alcohol will not hydrolyze because it has no hydrolyzable functional group (Kollig, 1993).
    At an influent concentration of 1,000 mg/L, treatment with GAC resulted in effluent concentration of 705 mg/L. The adsorbability of the carbon used was 59 mg/g carbon (Guisti et al., 1974).
  • ShippingUN1120 Butanols, Hazard Class: 3; Labels: 3— Flammable liquid. UN1212 Isobutanol or Isobutyl alcohol, Hazard Class: 3; Labels: 3—Flammable liquid
  • Purification Methodstert-Butanol is synthesised commercially by the hydration of 2-methylpropene in dilute H2SO4. Dry it with CaO, K2CO3, CaSO4 or MgSO4, filter and fractionally distil it. Dry further by refluxing with, and distilling from, either magnesium activated with iodine, or small amounts of calcium, sodium or potassium, under nitrogen. Passage through a column of type 4A molecular sieve is another effective method of drying; as well as refluxing with tert-butyl phthalate or succinate. (For method see Ethanol.) Other methods include refluxing with excess aluminium tert-butylate, or standing with CaH2, and distilling as needed. Further purification is achieved by fractional crystallisation by partial freezing, taking care to exclude moisture. tert-Butyl alcohol samples containing much water can be dried by adding *benzene, so that the water distils off as a tertiary azeotrope, b 67.3o. Traces of isobutylene have been removed from dry tert-butyl alcohol by bubbling dry pre-purified nitrogen through for several hours at 40-50o before using. It forms azeotropic mixtures with a large number of compounds. It has also been purified by distillation from CaH2 into Linde 4A molecular sieves which had been activated at 350o for 24hours [Jaeger et al. J Am Chem Soc 101 717 1979]. [Beilstein 1 IV 1609.] Rapid purification: Dry tert-butanol over CaH2 (5% w/v), distil and store it over 3A molecular sieves.
  • IncompatibilitiesButyl alcohols may form explosive mixture with air. In all cases they are Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some plastics, rubber and coatings. n-Butanol is incompatible with strong acids; halogens, caustics, alkali metals; aliphatic amines; isocyanates. sec-Butanol forms an explosive peroxide in air. Ignites with chromium trioxide. Incompatible with strong oxidizers; strong acids; aliphatic amines; isocyanates, organic peroxides. tert-Butanol is incompatible with strong acids (including mineral acid), including mineral acids; strong oxidizers or caustics, aliphatic amines; isocyanates, alkali metals (i.e., lithium, sodium, potassium, rubidium, cesium, francium). isoButanol is incompatible with strong acids; strong oxidizers; caustics, aliphatic amines; isocyanates, alkali metals and alkali earth. May react with aluminum at high temperatur
  • Waste DisposalIncineration, or bury absorbed waste in an approved land fill.
tert-Butanol Preparation Products And Raw materials
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