Phenol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H341：Kann vermutlich genetische Defekte verursachen.

  H373：Kann die Organe schädigen bei längerer oder wiederholter Exposition.

  H411：Giftig für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Phenol Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE BIS GELBE ODER ROSAFARBENE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Beim Erhitzen bilden sich giftige Rauche. Schwache Säure in wässriger Lösung. Reagiert mit Oxidationsmitteln. Feuer- und Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV: 5 ppm (als TWA) Hautresorption; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); BEI vorhanden; (ACGIH 2005).
  MAK: Hautresorption; Krebserzeugend Kategorie 3B; (DFG 2005).
  

• AUFNAHMEWEGE

  Schnelle Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20 °C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz bzw. der Dampf verätzt die Augen, die Haut und die Atmungsorgane. Inhalation des Dampfes kann zu Lungenödem führen (s. Anm.). Möglich sind Auswirkungen auf Zentralnervensystem, Herz und Nieren mit nachfolgenden Krämpfen, Koma, Herzfunktionsstörungen, Atemversagen und Kollaps. Exposition kann zum Tod führen. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen. Möglich sind Auswirkungen auf Leberund Nieren.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. NICHT in die Umwelt gelangen lassen.

• R-Sätze Betriebsanweisung:

  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R34:Verursacht Verätzungen.
  R48/20/21/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R68:Irreversibler Schaden möglich.
  R40:Verdacht auf krebserzeugende Wirkung.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R11:Leichtentzündlich.
  R36:Reizt die Augen.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S1/2:Unter Verschluss und für Kinder unzugänglich aufbewahren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.

• Aussehen Eigenschaften

  C6H6O
  Monohydroxybenzol, Karbolsäure

• Gefahren für Mensch und Umwelt

  Mit Aluminium, Aldehyden, Brom, Calciumhypochlorit, Natriumnitrit, Natriumnitrat, Peroxoschwefelsäuren, Wasserstoffperoxid/eisen(III)-katalysator gefährliche Reaktionen möglich.
  Mit Luft Bildung explosionsfähiger Gemische möglich.
  Verätzungen nach Augen- und Hautkontakt, Erblindungsgefahr! Schleimhautirritationen nach Verschlucken. ZNS-Störungen, Herz-kreislaufstörungen, Blutbildveränderungen. Gefahr der Hautresorption, NTP-bewertung auf Kanzerogenität negativ beim Tier.
  toxisch für Wasserorganismen: Gefahr für das Trinkwasser!
  Wassergefährdend (WGK 2).

• Schutzmaßnahmen und Verhaltensregeln

  Dicht verschlossen, trocken, unter Lichtschutz, an gut belüftetem Ort.
  Schutzbrille mit Seitenschutz und oberer Augenraumabdeckung
  Neoprenhanschuhe (als kurzzeitiger Spritz- und Staubschutz).

• Verhalten im Gefahrfall

  Vorsichtig trocken aufnehmen, entsorgen, nachreinigen.

• Erste Hilfe

  Nach Hautkontakt: Mit viel Wasser waschen, mit Polyethylenglykol 400 abtupfen.
  Nach Augenkontakt: 15 Minuten bei gespreizten Lidern unter fließendem Wasser mit Augendusche ausspülen. Augenarzt konsultieren!
  Nach Einatmen: Frischluft, ggf. Atemspende/Gerätebeatmung
  Nach Verschlucken: Viel Wasser trinken, erbechen, Aktivkohle (20-40g), Arzt!
  Nach Kleidungskontakt: kontaminierte Kleidung sofort ausziehen
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sonderabfall entsorgen, zuständige Stellen: Hubland-Herr Riepl:8884711, Klinikum-Herr Uhl:2015557.

• Beschreibung

  Phenol is a stable chemical substance and appear as colourless/white crystals with a characteristic, distinct aromatic/acrid odour. It is reactive and incompatible with strong oxidising agents, strong bases, strong acids, alkalis, and calcium hypochlorite. Phenol is flammable and may discolour in light. Phenol is used in the manufacture or production of explosives, fertiliser, coke, illuminating gas, lampblack, paints, paint removers, rubber, perfumes, asbestos goods, wood preservatives, synthetic resins, textiles, drugs, and pharmaceutical preparations. It is also extensively used as a disinfectant in the petroleum, leather, paper, soap, toy, tanning, dye, and agricultural industries.

• Chemische Eigenschaften

  Phenol, C6H5OH, also known as carbolic acid and phenylic acid, is a white poisonous crystalline solid that melts at 43 °C (110 OF) and boils at 182°C (360 OF). Phenol has a sharp burning taste,a distinctive odor, and it irritates tissue. It is toxic not only by ingestion or inhalation, but also by skin absorption. Phenol is soluble in water,alcohol,and ether. It is used in the production of resins,germicides,weedkillers,pharmaceuticals, and as a solvent in the refining of lubricating oils.

• Chemische Eigenschaften

  Phenol has a strong odor that is sickeningly sweet and irritating. Phenol has powerful disinfectant and sanitizing qualities. It has been used as a topical anesthetic and antiseptic preservative, reagent and chemical reactant. Its use for direct addition to food is limited to a role as a flavoring ingredient in a few foods at a maximum level below 10 ppm.

• Physikalische Eigenschaften

  Phenol is a colorless or white crystalline solid that is slightly soluble in water. Phenol is the simplest of the large group of organic chemicals known as phenols, which consist of compounds where a carbon in the phenyl aromatic group (C6H5) is directly bonded to hydroxyl, OH.

• Occurrence

  It is reported found in over 150 natural products including apricot, sour cherry, black currant, bilberry, cranberry, other berries, grapes, guava fruit, peach, pineapple, asparagus, onion, cooked potato, tomato, cinnamon bark, cassia leaf, ginger, pennyroyal oil, many cheeses, butter, milk, milk powder, boiled egg, fish and fish oil, cooked and cured meats, beer, wheaten bread, crisp bread, cognac, rose wine, cocoa, coffee, tea, whiskies, roasted filbert, roasted peanut, soybean, pecans, honey, avocado, Arctic bramble, passion fruit, beans, mushrooms, burley tobacco, cooked beef and chicken, fermented soy sauce, trassi, roasted almonds, sesame seed, fenugreek, mango, tamarind, Brazil nut, rice, rhubarb, licorice, buckwheat, watercress, malt, wort, dried bonito, loquat, myrtle berry, rosemary, Tahiti and Bourbon vanilla, endive, shrimp, crab, crayfish, clam, squid, truffle and Chinese quince.

• History

  Phenol’s first prominent use was by Joseph Lister (1827–1912) as an antiseptic. Throughout human history,infection often resulted in death,even when the wound could be surgically treated.A broken bone piercing the skin, which today is a painful but not life-threatening injury,historically resulted in infection and possible amputation or death. Lister was inspired by Louis Pasteur’s (1822–1895) germ theory of disease,and he began to use antiseptic methods during routine surgery during the 1860s.

• Verwenden

  Phenol is used in the manufacture of variousphenolic resins; as an intermediate in the production of many dyes and pharmaceuticals;as a disinfectant for toilets, floors, and drains;as a topical antiseptic; and as a reagentin chemical analysis. It has been detectedin cigarette smoke and automobile exhaust.Smoke emitted from a burning mosquito coil(a mosquito repellent) has been found to con-tain submicron particles coated with phenoland other substances; a lengthy exposure canbe hazardous to health (Liu et al. 1987).

• Verwenden

  The predominant use of phenol today is for phenolic resins.it is a powerful bactericide,phenol can be found in numerous consumer products includingmouthwashes,antiseptic ointments,throat lozenges,air fresheners,eardrops,and lipbalms.
  Phenol continues to be a primary chemical used to make thermoset resins.These resinsare made by combining phenol with aldehydes such as formaldehyde.More than 4 billionpounds of phenolic resins are used annually in the United States.Phenolic resins findtheir widest use in the construction industry.They are used as binding agents and fillers inwood products such as plywood,particleboard,furniture, and paneling.Phenolic resins areimpregnated into paper,which,after hardening,produces sheets that can be glued togetherto form laminates for use in wall paneling and countertops.Decking in boats and docksare made from phenolic resin composites.Phenolic resins are used as sealing agents andfor insulation. Because phenolic resins have high heat resistance and are good insulators,they are used in cookware handles.Because they are also good electrical insulators,they areused in electrical switches,wall plates, and for various other electrical applications.In theautomotive industry,phenolic resins are used for parts such as drive pulleys,water pumphousings, brakes,and body parts.
  In addition to the construction industry,phenol has many other applications.It isused in pharmaceuticals,in herbicides and pesticides,and as a germicide in paints.It can beused to produce caprolactam,which is the monomer used in the production of nylon 6.Another important industrial compound produced from phenol is bisphenol A,which ismade from phenol and acetone.Bisphenol A is used in the manufacture of polycarbonateresins.Polycarbonate resins are manufactured into structural parts used in the manufactureof various products such as automobile parts,electrical products,and consumer appliances.Items such as compact discs, reading glasses,sunglasses,and water bottles are made frompolycarbonates.

• Verwenden

  phenol is frequently used for medical chemical face peels. It may trap free radicals and can act as a preservative. Phenol, however, is an extremely caustic chemical with a toxicity potential. It is considered undesirable for use in cosmetics. even at low concentrations, it frequently causes skin irritation, swelling, and rashes.

• Definition

  ChEBI: An organic hydroxy compound that consists of benzene bearing a single hydroxy substituent. The parent of the class of phenols.

• Vorbereitung Methode

  Historically, phenol was produced by the distillation of coal tar. Today, phenol is prepared by one of several synthetic methods, such as the fusion of sodium benzenesulfonate with sodium hydroxide followed by acidification; the hydrolysis of chlorobenzene by dilute sodium hydroxide at high temperature and pressure to give sodium phenate, which on acidification liberates phenol (Dow process); or the catalytic vapor-phase reaction of steam and chlorobenzene at 500°C (Raschig process).

• Vorbereitung Methode

  Phenol was prepared before World War I through the distillation of coal tar. The firstsynthetic process involved the sulfonation of benzene followed by desulfonation with abase.
  The most common current method of phenol production is from the cumene hydroperoxiderearrangement process.In this process,benzene reacts with propylene to produce cumene.Cumene is oxidized to cumene hydroperoxide.When cumene hydroperoxide is treated withdilute sulfuric acid,it rearranges and splits into phenol and acetone. Because the reactants areinexpensive and the process is simple,the acidic oxidation of cumene is used to produce morethan 95% of the world’s supply of phenol.

• Definition

  1. (carbolic acid, hydroxybenzene, C₆H₅OH) A white crystalline solid used to make a variety of other organic compounds.
  2. A type of organic compound in which at least one hydroxyl group is bound directly to one of the carbon atoms of an aromatic ring. Phenols do not show the behavior typical of alcohols. In particular they are more acidic because of the electron-withdrawing effect of the aromatic ring. The preparation of phenol itself is by fusing the sodium salt of the sulfonic acid with sodium hydroxide:
  C₆H₅SO₂.ONa + 2NaOH → C₆H₅ONa
  + Na₂SO₃ + H₂O
  The phenol is then liberated by sulfuric acid:
  2C₆H₅ONa + H₂SO₄ → 2C₆H₅OH + Na₂SO₄
  Reactions of phenol include:
  1. Replacement of the hydroxyl group with a chlorine atom using phosphorus(V) chloride.
  2. Reaction with acyl halides to form esters of carboxylic acids. 3. Reaction with haloalkanes under alkaline conditions to give mixed alkyl–aryl ethers.
  In addition phenol can undergo further substitution on the benzene ring. The hydroxyl group directs other substituents into the 2- and 4-positions.

• synthetische

  Phenol is formed in dry distillation of wood, peat and coal; coal tar is one of the commercial sources of phenol and its homologues.

• Indications

  Phenol in dilute solution (0.5% to 2%) decreases itch by anesthetizing the cutaneous nerve endings. Phenol should never be used on pregnant women or infants younger than 6 months of age.

• Weltgesundheitsorganisation (WHO)

  Phenol became widely used as an antiseptic following demonstration of its germicidal activity in 1867. It is an intensely corrosive substance and percutaneous absorption can produce serious systemic toxicity. It has been withdrawn from pharmaceutical preparations by at least one national regulatory authority. However, it is still used widely in concentrations of the order of 1.4% in proprietary preparations for the relief of soreness of the mouth and throat.

• Aroma threshold values

  Detection: 5.5 ppm. Aroma characteristics at 1.0%: medicinal, creosote, smoky, spicy, phenolic, leatherlike with notes of fried meat and coffee.

• Taste threshold values

  Taste characteristics at 3 ppm: spicy, phenolic, tobacco, musty, woody, medicinal, smoky, tarlike and slightly spicy clovelike.

• Synthesis Reference(s)

  Journal of the American Chemical Society, 107, p. 2153, 1985 DOI: 10.1021/ja00293a054
  Synthetic Communications, 19, p. 453, 1989 DOI: 10.1080/00397918908050686

• Allgemeine Beschreibung

  A solid melting at 110°F. Colorless if pure, otherwise pink or red. Flash point 175°F. Density 9.9 lb / gal. Vapors are heavier than air Corrosive to the skin (turning skin white) but because of its anesthetic quality numbs rather than burn. Lethal amounts can be absorbed through the skin. Used to make plastics and adhesives.

• Air & Water Reaktionen

  Decomposes slowly in air. Mixtures of 9-10% phenol in air are explosive. Soluble in water

• Reaktivität anzeigen

  PHENOL is a weak acid. Reacts exothermically with bases. Reacts with strong oxidizing agents. Emits acrid smoke and irritating fumes when heated to decomposition. Undergoes, in the presence of aluminum chloride, potentially explosive reactions with nitromethane, butadiene, formaldehyde, peroxodisulfuric acid, peroxosulfuric acid, and sodium nitrite . Reacts violently with sodium nitrate in the presence of trifluoroacetic acid [Bretherick, 5th ed., 1995, p. 770]. May corrode lead, aluminum and its alloys, certain plastics, and rubber. Phenol may explode in contact with peroxodisulfuric acid (Dns, J. Ber., 1910, 43, 1880; Z. Anorg. Chem., 1911, 73, 1911.) or peroxomonosulfuric acid. (Sidgwick, 1950, 939)

• Health Hazard

  Phenol and its vapors are corrosive to the eyes, skin, and respiratory tract. The corrosive effect on skin and mucous membranes is due to a protein-degenerating effect. Repeated or prolonged skin contact with phenol may cause dermatitis, and potentially second and third-degree burns. Inhalation of phenol vapor may cause lung edema. Phenol may adversely effect the central nervous system and heart. Long-term, or repeated exposure, to phenol may have harmful effects on the liver and kidneys.
  While there is no evidence that phenol causes cancer in humans it is readily absorbed through the skin; systemic poisoning can occur in addition to the local caustic burns. Resorptive poisoning by a large quantity of phenol can occur even with only a small area of skin, rapidly leading to paralysis of the central nervous system and a severe drop in body temperature. Phenol is also a reproductive toxin causing increased risk of abortion and low birth weight indicating retarded development in utero.
  Chemical burns from skin exposures can be decontaminated by washing with polyethylene glycol or isopropyl alcohol; flushing with copious amounts of water will help to remediate the burn. Removal of contaminated clothing is required, as well as immediate hospital treatment for large splashes.
  https://ehs.ucsc.edu/lab-safety-manual/specialty-chemicals/phenol.html

• Brandgefahr

  Flammable vapors when heated. Runoff from fire control water may give off poisonous gases and cause pollution. Mixtures of 9-10% phenol in air are explosive. Avoid aluminum chloride/nitrobenzene mixture, peroxodisulfuric acid, peroxomonosulfuric acid and strong oxidizing agents. Decomposes slowly on air contact. Avoid contact with strong oxidizing agents.

• Flammability and Explosibility

  Phenol is a combustible solid (NFPA rating = 2). When heated, phenol produces flammable vapors that are explosive at concentrations of 3 to 10% in air. Carbon dioxide or dry chemical extinguishers should be used to fight phenol fires.

• Pharmazeutische Anwendungen

  Phenol is used mainly as an antimicrobial preservative in parenteral pharmaceutical products. It has also been used in topical pharmaceutical formulations and cosmetics;
  Phenol is widely used as an antiseptic, disinfectant, and therapeutic agent, although it should not be used to preserve preparations that are to be freeze-dried.

• Industrielle Verwendung

  Phenol is the simplest member of a class oforganic compounds possessing a hydroxylgroup attached to a benzene ring or to a morecomplex aromatic ring system.
  Also known as carbolic acid or monohydroxybenzene,phenol is a colorless to whitecrystalline material of sweet odor, having thecomposition C₆H₅OH, obtained from the distillationof coal tar and as a by-product ofcoke ovens.
  Phenol has broad biocidal properties, anddilute aqueous solutions have long been usedas an antiseptic. At higher concentrations itcauses severe skin burns; it is a violent systemicpoison. It is a valuable chemical raw materialfor the production of plastics, dyes, pharmaceuticals,syntans, and other products.
  Phenol is one of the most versatile industrialorganic chemicals. It is the starting point formany diverse products used in the home andindustry. A partial list includes nylon, epoxyresins, surface active agents, synthetic detergents,plasticizers, antioxidants, lube oil additives,phenolic resins (with formaldehyde, furfural,and so on), cyclohexanol, adipic acid,polyurethanes, aspirin, dyes, wood preservatives,herbicides, drugs, fungicides, gasolineadditives, inhibitors, explosives, and pesticides.

• Biochem/physiol Actions

  Phenol?has the ability to denature protein, hence can lead to denervation. At lower concentration, it can serve as a local anaesthetic and can also act as a neurolytic agent in higher concentration. It is also linked with tissue damage at higher concentrations.

• Sicherheit(Safety)

  Phenol is highly corrosive and toxic, the main effects being on the central nervous system. The lethal human oral dose is estimated to be 1 g for an adult.
  Phenol is absorbed from the gastrointestinal tract, skin, and mucous membranes, and is metabolized to phenylglucuronide and phenyl sulfate, which are excreted in the urine.
  Although there are a number of reports describing the toxic effects of phenol, these largely concern instances of accidental poisoning or adverse reactions during its use as a therapeutic agent.Adverse reactions associated with phenol used as a preservative are less likely owing to the smaller quantities that are used; however, it has been suggested that the body burden of phenol should not exceed 50 mg in a 10-hour period.This amount could be exceeded following administration of large volumes of phenolpreserved medicines.
  LD₅₀ (mouse, IV): 0.11 g/kg
  LD₅₀ (mouse, oral): 0.3 g/kg
  LD₅₀ (rabbit, skin): 0.85 g/kg
  LD₅₀ (rat, skin): 0.67 g/kg
  LD₅₀ (rat, oral): 0.32 g/kg
  LD₅₀ (rat, SC): 0.46 g/kg

• mögliche Exposition

  Phenol is used as a pharmaceutical, in the production of fertilizer; coke, illuminating gas; lampblack, paints, paint removers; rubber, asbestos goods; wood preservatives; synthetic resins; textiles, drugs, pharmaceutical preparations; perfumes, bakelite, and other plastics (phenolformaldehyde resins); polymer intermediates (caprolactam, bisphenol-A and adipic acid). Phenol also finds wide use as a disinfectant and veterinary drug.

• Carcinogenicity

  Phenol had been investigated for carcinogenicity in animals by the oral and dermal routes. IARC and IRIS determined that animal human evidence for carcinogenicity was inadequate.

• Source

  Detected in distilled water-soluble fractions of 87 octane unleaded gasoline (1.53 mg/L), 94 octane unleaded gasoline (0.19 mg/L), Gasohol (0.33 mg/L), No. 2 fuel oil (0.09 mg/L), jet fuel A (0.09 mg/L), diesel fuel (0.07 mg/L), and military jet fuel JP-4 (0.22 mg/L) (Potter, 1996). Phenol was also detected in 80% of 65 gasoline (unleaded regular and premium) samples (62 from Switzerland, 3 from Boston, MA). At 25 °C, phenol concentrations ranged from 63 to 130,000 μg/L in gasoline and from 150 to 1,500 μg/L in water-soluble fractions. Average concentrations were 26 mg/L in gasoline and 6.1 mg/L in water-soluble fractions (Schmidt et al., 2002).
  Thomas and Delfino (1991) equilibrated contaminant-free groundwater collected from Gainesville, FL with individual fractions of three individual petroleum products at 24–25 °C for 24 h. The aqueous phase was analyzed for organic compounds via U.S. EPA approved test method 625. Average phenol concentrations reported in water-soluble fractions of unleaded gasoline, kerosene, and diesel fuel were 20, 8, and 19 μg/L, respectively.
  A high-temperature coal tar contained phenol at an average concentration of 0.61 wt % (McNeil, 1983).
  Phenol occurs naturally in many plants including blueberries (10 to 60 ppb), marjoram (1,431– 8,204 ppm), sweetflag, safflower buds (40 ppb), mud plantain, capillary wormwood, asparagus shoots, tea leaves, petitgrain, cinnamon, cassia, licorice, witch hazel, Japanese privet, St. John’s wort, European pennyroyal, tomatoes, white mulberries, tobacco leaves, benneseed, sesame seeds, tamarind, white sandlewood, patchouli leaves, rue, slash pine, bayberries, Scotch pine, and tarragon (Duke, 1992).
  A liquid swine manure sample collected from a waste storage basin contained phenol at a concentration of 22.0 mg/L (Zahn et al., 1997).
  Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rates of phenol were 525 mg/kg of pine burned, 300 mg/kg of oak burned, and 434 mg/kg of eucalyptus burned.
  Releases toxic and noxious fumes when heated at temperatures greater than its boiling point.
  Drinking water standard: No MCLGs or MCLs have been proposed, however, a DWEL of 20 mg/L was recommended (U.S. EPA, 2000).

• Environmental Fate

  Biological. Under methanogenic conditions, inocula from a municipal sewage treatment plant digester degraded phenol to carbon dioxide and methane (Young and Rivera, 1985). Chloroperoxidase, a fungal enzyme isolated from Caldariomyces fumago, reacted with phenol forming 2- and 4-chlorophenol, the latter in a 25% yield (Wannstedt et al., 1990). In activated sludge, 41.4% mineralized to carbon dioxide after 5 d (Freitag et al., 1985). When phenol was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, significant biodegradation with rapid adaptation was observed. At concentrations of 5 and 10 mg/L, 96 and 97% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981). Phenol is rapidly degraded in aerobically incubated soil but is much slower under anaerobic conditions (Baker and Mayfield, 1980).
  Soil. Loehr and Matthews (1992) studied the degradation of phenol in different soils under aerobic conditions. In a slightly basic sandy loam (3.25% organic matter) and in acidic clay soil (<1.0% organic matter), the resultant degradation half-lives were 4.1 and 23 d, respectively. Soil sorption distribution coefficients (Kd) were determined from centrifuge column tests using kaolinite as the absorbent (Celorie et al., 1989). Values for Kd ranged from 0.010 to 0.054 L/g.
  Surface Water. Vaishnav and Babeu (1987) reported a half-life of 11 d in river waters and 3 d in harbor waters.
  Groundwater. Nielsen et al. (1996) studied the degradation of phenol in a shallow, glaciofluvial, unconfined sandy aquifer in Jutland, Denmark. As part of the in situ microcosm study, a cylinder that was open at the bottom and screened at the top was installed through a cased borehole approximately 5 m below grade. Five liters of water was aerated with atmospheric air to ensure aerobic conditions were maintained. Groundwater was analyzed weekly for approximately 3 months to determine phenol concentrations with time. The experimentally determined first-order biodegradation rate constant and corresponding half-life were 0.5/d and 33.4 h, respectively. Vaishnav and Babeu (1987) reported a biodegradation rate constant of 0.035/d and a half-life of 20 d in groundwater.
  Photolytic. Absorbs UV light at a maximum wavelength of 269 nm (Dohnal and Fenclová, 1995). In an aqueous, oxygenated solution exposed to artificial light (λ = 234 nm), phenol was photolyzed to hydroquinone, catechol, 2,2 -, 2,4 - and 4,4 -dihydroxybiphenyl (Callahan et al., 1979). When an aqueous solution containing potassium nitrate (10 mM) and phenol (1 mM) was irradiated with UV light (λ = 290–350 nm) up to a conversion of 10%, the following products formed: hydroxyhydroquinone, hydroquinone, resorcinol, hydroxybenzoquinone, benzoquinone, catechol, nitrosophenol, 4-nitrocatechol, nitrohydroquinone, 2- and 4-nitrophenol. Catechnol and hydroquinone were the major and minor products, respectively (Niessen et al., 1988). Titanium dioxide suspended in an aqueous solution and irradiated with UV light (λ = 365 nm) converted phenol to carbon dioxide at a significant rate (Matthews, 1986).
  Chemical/Physical. In an environmental chamber, nitrogen trioxide (10,000 ppb) reacted quickly with phenol (concentration 200 ppb to 1.4 ppm) to form phenoxy radicals and nitric acid (Carter et al., 1981). The phenoxy radicals may react with oxygen and nitrogen dioxide to form quinones and nitrohydroxy derivatives, respectively (Nielsen et al., 1983).

• Lager

  When exposed to air and light, phenol turns a red or brown color, the color being influenced by the presence of metallic impurities. Oxidizing agents also hasten the color change. Aqueous solutions of phenol are stable. Oily solutions for injection may be sterilized in hermetically sealed containers by dry heat. The bulk material should be stored in a well-closed, light-resistant container at a temperature not exceeding 15°C.

• Versand/Shipping

  UN1671 Phenol, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2312 Molten phenol, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2821 Phenol solutions, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• läuterung methode

  Steam is passed through a boiling solution containing 1mole of phenol and 1.5-2.0moles of NaOH in 5L of H2O until all non-acidic material has distilled. The residue is cooled, acidified with 20% (v/v) H2SO4, and the phenol is separated, dried with CaSO4 and fractionally distilled under reduced pressure. It is then fractionally crystallised several times from its melt [Andon et al. J Chem Soc 5246 1960]. Purification via the benzoate has been used by Berliner, Berliner and Nelidow [J Am Chem Soc 76 507 1954]. The benzoate,(m 70o, b 314o/760mm), is crystallised from 95% EtOH, then hydrolysed to the free phenol by refluxing with two equivalents of KOH in aqueous EtOH until the solution becomes homogeneous. It is acidified with HCl and extracted with diethyl ether. The ether layer is freed from benzoic acid by thorough extraction with aqueous NaHCO3, and, after drying and removing the ether, the phenol is distilled. Phenol has also been crystallised from a 75% w/w solution in water by cooling to 11o and seeding with a crystal of the hydrate. The crystals are centrifuged off, rinsed with cold water (0-2o), saturated with phenol, and dried. It can be crystallised from pet ether [Berasconi & Paschalis J Am Chem Soc 108 2969 1986]. Draper and Pollard [Science 109 448 1949] added 12% water, 0.1% aluminium (can also use zinc) and 0.05% NaHCO3 to phenol, and distilled it at atmospheric pressure until the azeotrope was removed, The phenol was then distilled at 25mm. Phenol has also been dried by distillation from the *benzene solution to remove the water/*benzene azeotrope and the excess *benzene, followed by distillation of the phenol at reduced pressure under nitrogen. Processes such as this are probably adequate for analytical grade phenol which has as its main impurity water. Phenol has also been crystallised from pet ether/*benzene or pet ether (b 40-60o). The purified material is stored in a vacuum desiccator over P2O5 or CaSO4. [Beilstein 6 IV 531.]

• Inkompatibilitäten

  Phenol, available in solid or liquid form, is colorless to light pink and has a sweet aromatic odor. It is stable under normal conditions of storage and use. The liquid and vapor are combustible. Phenol is incompatible with strong oxidizing agents, calcium hypochlorite, halogens, halogenated compounds, aluminum chloride, and nitrobenzene. Hot phenol can attack aluminum, lead, magnesium and zinc. It can react exothermally with peroxymonosulfuric acid, sodium nitrate, 1,3-butadiene and boron trifluoride diethyl ether. When phenol is heated to decomposition (ca. 715 °C), decomposition products include carbon monoxide and carbon dioxide.
  https://www.cdc.gov/niosh/npg/npgd0493.html
  http://www51.honeywell.com/sm/common/documents/Public_Risk_Summary_-_GPS0075_Phenol_Dec_2012.pdf

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.

• Vorsichtsmaßnahmen

  Acute poisoning of phenol by ingestion, inhalation or skin contact may lead to death. Phenol is readily absorbed through the skin. It is highly toxic by inhalation. It is corrosive and causes burns and severe irritation effects. During use and handling of phenol, occupational workers should be very careful. Workers should use protective clothing, rubber boots, and goggles to protect the eyes from vapors and spillage.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (injections). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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