Bisacodyl

Bezeichnung:Bisacodyl

CAS-Nr603-50-9

Englisch Name:Bisacodyl

CBNumberCB2233693

SummenformelC22H19NO4

Molgewicht361.39

MOL-Datei603-50-9.mol

Synonyma

Bisacodyl

Bisacodyl physikalisch-chemischer Eigenschaften

Schmelzpunkt	138°C
Siedepunkt	493.21°C (rough estimate)
Dichte	1.2545 (rough estimate)
Brechungsindex	1.5614 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
pka	4.69±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
maximale Wellenlänge (λmax)	220nm(MeOH)(lit.)
Merck	14,1242
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	KHOITXIGCFIULA-UHFFFAOYSA-N
LogP	3.453 (est)
CAS Datenbank	603-50-9(CAS DataBase Reference)
NIST chemische Informationen	Bisacodyl(603-50-9)
EPA chemische Informationen	Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (603-50-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	SM8750000
TSCA	Yes
HS Code	2933399090
Giftige Stoffe Daten	603-50-9(Hazardous Substances Data)
Toxizität	LD50 orally in rats: >3 g/kg (Schmidt)

Gefahreninformationscode (GHS)

Bisacodyl Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline Solid
Originator
Dulcolax,Boehringer Ingelheim,US,1958
Verwenden
Stimulant laxative.
Verwenden
Cathartic.
Verwenden
Bisacodyl is used in the inhibition of (Na+K)ATPase, the increase of mucosal PGE2, and the activation of adenyl cyclase in rat intestine studies. It is used as a laxative drug. It is typically prescribed for relief of constipation.
Definition
ChEBI: Bisacodyl is a diarylmethane.
Manufacturing Process
Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane 70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and cooling to a mixture of 200 grams of phenol and 100 cc of concentrated sulfuric acid. The reaction mixture is allowed to stand for a while with repeated stirring, whereby it becomes syrupy, neutralized with sodium carbonate, dissolved in methanol and filtered. The filtrate is introduced into a large quantity of water and the resulting precipitate is recrystallized from a methanol/water mixture. Colorless crystals are obtained of MP 254°C. When using zinc chloride or tin tetrachloride and warming to a temperature of about 50°C, a corresponding result is obtained.
Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)- methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of acetic anhydride for three hours over a boiling water bath. The cooled reaction mixture is poured into water, whereby after a while a colorless substance precipitates, which is filtered off with suction, washed with water and recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are obtained.
Trademarks
Correctol Tablets, Caplets (Schering-Plough HealthCare); Dulcolax (Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a- Mint Tablets (Schering-Plough HealthCare); Modane (Savage); SK-Bisacodyl (SmithKline Beecham); Theralax (SmithKline Beecham).
Therapeutic Function
Laxative
Clinical Use
Laxative
Veterinary Drugs and Treatments
Bisacodyl oral and rectal products are used as stimulant cathartics in dogs and cats.
Stoffwechsel
Bisacodyl is rapidly hydrolysed to the active principle bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), mainly by esterases of the enteric mucosa. After oral and rectal administration, only small amounts of the drug are absorbed and are almost completely conjugated in the intestinal wall and the liver to form the inactive BHPM glucuronide. Following the administration of bisacodyl coated tablets, an average of 51.8% of the dose was recovered in the faeces as free BHPM and an average of 10.5% of the dose was recovered in the urine as BHPM glucuronide. Following the administration as a suppository, an average of 3.1% of the dose was recoveredas BHPM glucuronide in the urine. Stool contained large amounts of BHPM (90% of the total excretion) in addition to small amounts of unchanged bisacodyl

Bisacodyl Upstream-Materialien And Downstream Produkte

Bisacodyl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

603-50-9, Bisacodyl Verwandte Suche:

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