Triacetin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H303：May be harmfulif swallowed

• Sicherheit

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P403：An einem gut belüfteten Ort aufbewahren.

Triacetin Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE, öLIGE FLüSSIGKEIT

• CHEMISCHE GEFAHREN

  Reagiert mit starken Oxidationsmitteln.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt.
  MAK nicht festgelegt.
  

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt schwach die Haut.

• LECKAGE

  Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.

• S-Sätze Betriebsanweisung:

  S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Aussehen Eigenschaften

  C9H14O6; Triacetin, 1,2-Propantriol-triacetat. Farblose Flüssigkeit mit ranzigem Geruch.

• Gefahren für Mensch und Umwelt

  Kann mit Luft explosionsfähige Gemische bilden. Brennbar.
  Reizt Haut und Augen.
  LD₅₀ (oral, Ratte): 3000 mg/kg

• Schutzmaßnahmen und Verhaltensregeln

  Geeignete Schutzhandschuhe als kurzzeitiger Spritzschutz.

• Verhalten im Gefahrfall

  Mit flüssigkeitsbindendem Material, z.B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Mit Wasser nachreinigen.
  Kohlendioxid, Wasser, Pulver.
  Brennbar. Mit Luft Bildung explosionsfähiger Gemische möglich.

• Erste Hilfe

  Nach Hautkontakt: Mit reichlich Wasser abspülen.
  Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Augenarzt hinzuziehen.
  Nach Einatmen: Frischluft.
  Nach Verschlucken: Reichlich Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als halogenfreie, organische Lösemittelabfälle.

• Beschreibung

  § 184.1901(a) Triacetin (C8H14O6), also known as 1,2,3-propanetriol triacetate or glyceryl triacetate, is the triester of glycerin and acetic acid. Triacetin can be prepared by heating glycerin with acetic anhydride alone or in the presence of finely divided potassium hydrogen sulfate. It can also be prepared by the reaction of oxygen with a liquid-phase mixture of allyl acetate and acetic acid using a bromide salt as a catalyst.

• Chemische Eigenschaften

  Triacetin is a colorless, viscous liquid with a slightly fatty odor.

• Chemische Eigenschaften

  Colorless liquid; slight fatty odor; bitter taste. Slightly soluble in water; very soluble in alcohol, ether, and other organic solvents. Combustible.

• Chemische Eigenschaften

  Triacetin has a very faint, fruity odor. It has a mild, sweet taste that is bitter above 0.05%.

• Originator

  Enzactin,Ayerst,US,1957

• Occurrence

  Reported found in papaya.

• Verwenden

  Triacetin is a colorless, oily liquid of slight fatty odor and bitter taste. It is soluble with water and is miscible with alcohol and ether. It functions in foods as a humectant and solvent.

• Verwenden

  As fixative in perfumery; solvent in manufacture of celluloid, photographic films. Technical triacetin (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.

• Verwenden

  Triacetin, a component of cigarette filters, induced a contact dermatitis in a worker at a cigarette manufacturers.

• Definition

  ChEBI: A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.

• Vorbereitung Methode

  Triacetin is prepared by the esterification of glycerin with acetic anhydride.

• synthetische

  By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.

• Manufacturing Process

  200 grams of allyl acetate, 450 grams of glacial acetic acid and 3.71 grams of cobaltous bromide were charged to the reactor and the mixture was heated to 100°C. Pure oxygen was then introduced into the reactor below the surface of the liquid reaction mixture at the rate of 0.5 standard cubic feet per hour. Initially, all of the oxygen was consumed, but after a period of time oxygen introduced into the mixture passed through unchanged. During the course of the reaction, a small quantity of gaseous hydrogen bromide (a total of 1.9 grams) was introduced into the reaction zone, along with the oxygen. The reaction was allowed to continue for 6 hours following which the reaction mixture was distilled. Essentially complete conversion of the allyl acetate took place. A yield of 116 grams of glycerol triacetate was obtained, this being accomplished by distilling the glycerol triacetate overhead from the reaction mixture, at an absolute pressure of approximately 13 mm of mercury.

• Therapeutic Function

  Topical antifungal

• Taste threshold values

  Sweet and creamy with an oily mouthfeel.

• Allgemeine Beschreibung

  Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams, nonalcoholic beverages and baked goods.

• Pharmazeutische Anwendungen

  Triacetin is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.
  Triacetin is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.

• Kontakt-Allergie

  Triacetin is a component of cigarette filters, which induced a contact dermatitis in a worker at a cigarette manufactory.

• Clinical Use

  Glyceryl triacetate (Enzactin, Fungacetin) is a colorless, oilyliquid with a slight odor and a bitter taste. The compound issoluble in water and miscible with alcohol and most organicsolvents.
  The activity of triacetin is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin. Acid release is a self-limiting process becausethe esterases are inhibited below pH 4.

• Sicherheitsprofil

  Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. An eye irritant. Combustible when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

• Sicherheit(Safety)

  Triacetin is used in oral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels employed as an excipient.
  LD50 (dog, IV): 1.5 g/kg
  LD50 (mouse, IP): 1.4 g/kg
  LD50 (mouse, IV): 1.6 g/kg
  LD50 (mouse, oral): 1.1 g/kg
  LD50 (mouse, SC): 2.3 g/kg
  LD50 (rabbit, IV): 0.75 g/kg
  LD50 (rat, IP): 2.1 g/kg
  LD50 (rat, oral): 3 g/kg
  LD50 (rat, SC): 2.8 g/kg

• in vitro

  Litton Bionetics, Inc. (1976) evaluated the mutagenic potential of Triacetin in a plate test using Salmonella typhimurium strains TA1535, TA1537, and TA1538 with and without metabolic activation. Test concentrations were 0.0013%, 0.00065%, and 0.000325% and the solvent was dimethyl sulfoxide (DMSO). A negative control (solvent) and appropriate positive controls were used and gave expected results. Triacetin was not mutagenic with or without metabolic activation.
  Unichema Chemie B.V. (1994) reported that Triacetin was not mutagenic at 50 to 5000 μg/plate in an Ames test using S. typhimurium strains TA1535, TA1537, TA98, and TA100 with and without metabolic activation.

• in vivo

  The mutagenic potential of Triacetin was determined using adult Drosophila melanogaster (Efremova 1962). A dose of 0.2 to 0.3 mg Triacetin had a spontaneous mutation rate of approximately one mutation per 750 chromosomes.

• Lager

  Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.

• Inkompatibilitäten

  Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.

• Regulatory Status

  GRAS listed. Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules and tablets and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Triacetin Upstream-Materialien And Downstream Produkte

Triacetin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(709)Suppliers

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