Glycerol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H320：Causes eye irritation

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P337+P313：Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P370+P378：Bei Brand: zum Löschen verwenden.

  P403+P235：An einem gut belüfteten Ort aufbewahren. Kühl halten.

Glycerol Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  HYGROSKOPISCHE, VISKOSE, FARBLOSE FLüSSIGKEIT

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen unter Bildung ätzender Rauche von Acrolein. Reagiert mit starken Oxidationsmitteln. Feuer- und Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV: Nebel 10 mg/m?(als TWA) (ACGIH 2005).
  MAK: 50 mg/m?(Einatembarer Anteil); Spitzenbegrenzung: überschreitungsfaktor I(2); Schwangerschaft: Gruppe C; (DFG 2006).
  

• INHALATIONSGEFAHREN

  Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch schnell erreicht werden durch Versprühen.

• LECKAGE

  Belüftung. Ausgelaufene Flüssigkeit in abgedeckten Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.

• R-Sätze Betriebsanweisung:

  R36:Reizt die Augen.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S39:Schutzbrille/Gesichtsschutz tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Aussehen Eigenschaften

  C3H8O3; Glycerol, 1,2,3-Propantriol, Trihydroxipropan, Protol. Farblose, ölige Flüssigkeit ohne Geruch.

• Gefahren für Mensch und Umwelt

  Brennbar. Nicht stark erhitzen. Nicht mit starken Oxidationsmitteln, Gemischen aus konz. Salpeter- und Schwefelsäure, Phosphoroxiden, Wasserstoffperoxid, Halogenen und Peroxiden in Berührung bringen.
  Reizt die Augen.
  LD₅₀ (oral, Ratte): 12600 mg/kg

• Schutzmaßnahmen und Verhaltensregeln

  Geeignete Schutzhandschuhe als kurzzeitiger Spritzschutz.

• Verhalten im Gefahrfall

  Mit flüssigkeitsbindendem Material, z.B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
  Kohlendioxid, Wasser, Pulver, Schaum.
  Brennbar. Bei starker Erhitzung ist mit Luft die Bildung explosionsfähiger Gemische möglich.

• Erste Hilfe

  Nach Hautkontakt: Mit Wasser abwaschen.
  Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Augenarzt hinzuziehen.
  Nach Einatmen: Frischluft.
  Nach Verschlucken: Viel Wasser trinken lassen. Bei Unwohlsein Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung ablegen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als halogenfreie, organische Lösemittelabfälle.

• Beschreibung

  Glycerol is a colorless, viscous, hygroscopic, sweet-tasting trihydric alcohol. It is also called glycerin or glycerine, with the term glycerol being preferred as the pure chemical form and the term glycerin(e) being primarily used when the compound is used commercially in various grades.

• Chemische Eigenschaften

  Glycerin is a clear, colorless, odorless, viscous, hygroscopic liquid; it has a sweet taste, approximately 0.6 times as sweet as sucrose.

• Chemische Eigenschaften

  Glycerol is a sweet-tasting, syrupy liquid It has not more than a slight characteristic odor, which is neither harsh nor disagreeable Glycerol is a trihydric alcohol It is hygroscopic and its solutions are neutral.

• Chemische Eigenschaften

  Glycerol is a viscous colorless or pale yellow, odorless, syrupy liquid.

• Chemische Eigenschaften

  Glycerin is the polyhydric alcohol 1,2,3 propanetriol [HOCH2-CH(OH)CH2OH] also known as glycerol. A clear, colorless, syrupy liquid having a sweet taste. It has not more than a slight characteristic odor, which is neither harsh nor disagreeable. It is hygroscopic and its solutions are neutral. Glycerin is miscible with water and with alcohol. It is insoluble in chloroform, in ether, and in fixed and volatile oils.
  In the animal body, glycerin may be formed from ingested carbohydrates, from glycogen by glycolysis, and from fats and other lipids by hydrolysis. Commercially, glycerin can be produced by a number of methods including microbial fermentation of sugars, as a by-product in the manufacture of soap, or by synthesis from propylene.
  Animal and vegetable fats contain about 10 percent by weight of glycerin. It is present in animal tissues to the extent of about 1 percent of the body weight. Glycerin is not an essential nutrient, but it furnishes energy by contributing to the general pool of oxidizable organic compounds.

• Chemische Eigenschaften

  Glycerol,CH20HCHOHCH20H, also known as glycerin and glycyl alcohol, is a clear, colorless, viscous liquid with a sweet taste.It is the simplest trihydroxy alcohol and a valuable chemical intermediary, It is soluble in water and alcohol, but only partially soluble in ether and ethyl acetate. Glycerol is used in perfume and medicine,as an antifreeze,and in manufacturing soaps and explosives.

• Occurrence

  Reported found in cocoa, apple, cider, beer, sour cherries, peach and wine

• History

  Glycerol was first isolated from olive oil and lead oxide by the Swedish chemist Carl Scheele (1742–1786) while making lead plaster soap in 1779. Scheele eventually realized that glycerol was a common ingredient in fats and oils and referred to glycerol as “the sweet principle of fats.” In 1811, the French chemist Michel Eugene Chevreul (1786–1889), who was a pioneer in the study of fats and oils, proposed the name glycerine after the Greek word glucos, which means sweet. Chevreul decomposed soaps isolating different acids such as stearic and butyric acid and discovered that glycerol was liberated when oils and fats were boiled in a basic mixture. Th éophile-Jules Pelouze (1807–1867) derived glycerol’s empirical formula in 1836.

• Verwenden

  Glycerol's properties make it useful for numerous applications. The three hydroxyl groups in glycerol allow extensive hydrogen bonding that gives glycerol its characteristic syrupy viscous texture and hygroscopic character. Approximately 40% of glycerol's use is for personal care products such as cosmetics, soaps, shampoos, lotions, mouthwash, and toothpaste. Glycerol's hygroscopic properties make it a good moisturizer in skin products. Another 25% of glycerol's annual production is used in food production. In the food industry glycerol is used as a moistening agent, as a solvent for food coloring and syrups, to prevent crystallization of sugar in candies and icings, as a preservative, and as a sweetening agent. Approximately 10% of glycerol's use goes into tobacco processing, where it is sprayed on tobacco leaves before they are shredded to serve as a moistening agent. Glycerol has the added benefit of imparting a sweet taste to chewing tobacco. The remaining 25% of glycerol's use is distributed among various industrial uses. It is used in cough syrups and elixir medicines. In industry, glycerol is found in lubricants, plasticizers, adhesives, antifreezes, resins, and insulating foams. At one time it was used almost exclusively in its nitrated form as an explosive (see Nitroglycerin), which today accounts for about 3% of its use.

• Verwenden

  glycerin (glycerol; propanetriol) is a humectant used in moisturizers. It is water-binding and able to draw and absorb water from the air, thus helping the skin retain moisture. glycerin has been studied extensively for its hydrating abilities. Based on the data available, glycerin has been established as a good skin-moisturizing agent. At least part of its activity is attributed to its facilitating enzymatic reactions in the skin, thereby promoting corneocyte desquamation. glycerin also improves the spreading qualities of creams and lotions. It is a clear, syrupy liquid made by chemically combining water and fat that is usually derived from vegetable oil. Although glycerin has not been shown to cause allergies, it may be comedogenic and irritating to the mucous membranes when used in concentrated solutions.

• Verwenden

  Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.

• Verwenden

  As solvent, humectant, plasticizer, emollient, sweetener, in the manufacture of nitroglycerol (dynamite), cosmetics, liquid soaps, liqueurs, confectioneries, blacking, printing and copying inks, lubricants, elastic glues, lead oxide cements; to keep fabrics pliable; to preserve printing on cotton; for printing rollers, hectographs; to keep frost from windshields; as antifreeze in automobiles, gas meters and hydraulic jacks, in shock absorber fluids. In fermentation nutrients in the production of antibiotics. Pharmaceutic aid (humectant; solvent, vehicle). Leffingwell and Lesser (op. cit.) give 1583 different uses.

• synthetische

  Glycerol is the polyhydric alcohol most widely used for the preparation of alkyd resins and is obtained both synthetically and as a byproduct in the manufacture of soap. Most synthetic glycerol is obtained from propylene via allyl chloride:
  

  

  
  The first step is the 'hot' chlorination of propylene. A mixture of propylen(, and chlorine (4: 1 molar) is heated at about 500??C and 0.2 MPa (2 atmospheres). Under these conditions a free radical substitution reaction occurs rather than addition at the double bond and allyl chloride is the main product. This is treated with pre-formed hypochlorous acid (formed in a separate reactor by passing chlorine into water) at about 30??C to give the addition product, dichlorhydrin. The reaction mixture separates into two layers. The aqueous layer is removed to leave dichlorhydrin which is then stirred with a lime slurry to give epichlorhydrin. The epichlorhydrin is then hydrolysed to glycerol by treatment with aqueous sodium hydroxide at 150??C. The glycerol is produced as a dilute solution containing sodium chloride. Most of the water is evaporated off, during which operation the salt crystallizes out and is removed from the bottom of the evaporator to leave crude glycerol. The crude product is purified by distillation under reduced pressure. It may be noted that the intermediate epichlorhydrin has significance in its own right for the manufacture of epoxy resins.

• Vorbereitung Methode

  Glycerol is a by-product in the production of candles and soaps and was originally discardedin the production of these items. The process of converting a fat to soap is termedsaponification. The traditional method of saponification involved the use of animal fats andvegetable oils. Fats and oils are esters formed when three fatty-acid molecules attach to a singleglycerol molecule. When the three fatty acids attach to the three hydroxyl groups of the glycerol,a triglyceride is formed. During saponification of animal and plant products, hydrolysisof triglycerides converts triglycerides back to fatty acids and glycerol.the fatty acids then reactwith a base to produce a carboxylic acid salt commonly called soap.
  Until 1940, the world’s demand for glycerol was supplied from natural sources throughthe production of soaps and candles. Glycerol can also be produced through the fermentationof sugar, and this process was used to increase glycerol production during World War I.Glycerol can also be produced synthetically from propylene. The synthetic production frompropylene first occurred just before World War II and commercial production started in 1943in Germany. The synthetic process begins with the chlorine substitution of one hydrogenatom of propylene to allyl chloride: H₂C = CH-CH₃ + Cl₂ → H₂C = CH-CH₂Cl + HCl. Allylchloride is then treated with hypochlorous acid to produce 1,3-dichlorohydrin.

• Vorbereitung Methode

  Glycerin is mainly obtained from oils and fats as a by-product in the manufacture of soaps and fatty acids. It may also be obtained from natural sources by fermentation of, for example, sugar beet molasses in the presence of large quantities of sodium sulfite. Synthetically, glycerin may be prepared by the chlorination and saponification of propylene.

• Definition

  ChEBI: A triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups.

• Reaktionen

  Glycerol reacts (1) with phosphorus pentachloride to form glyceryl trichloride, CH2Cl·CHCl · CH2Cl, (2) with acids to form esters, e.g., glycerol monoacetate CH2OH ·CHOH·CH2OOCCH3, glycerol diacetate C3H5(OH)(OCOCH3)2, glycerol triacetate (triacetin), CH2OOCCH3·CHOOCCH3·CH2OOCCH3, glycerol mononitrates (alpha, CH2OH·CHOH·CH2ONO2; beta, CH2OH · CHONO2·CH2OH), glycerol dinitrates (1, 2,CH2OH· CHONO2·CH2 ONO2; 1, 3,CH2ONO2·CHOH·CH2ONO2), glyceryl trinitrate (“nitroglycerine”), CH2ONO2·CHONO2·CH2ONO2, glyceryl tristearate (tristearin), CH2OOCC17H35·CHOO-CC17H35·CH2OOCC17H35, indirectly, glycerol monophosphates (alpha, CH2OH·CHOH·CH2OPO(OH)2, beta, CH2OH·CHOPO(OH)2·CH2OH, (3) with oxidizing agents, e.g., dilute nitric acid, to form glyceric acid, CH2OH·CHOH·COOH, tartaric acid, COOH·CHOH·COOH, mesoxalic acid, COOH·CO·COOH, (4) with phosphorus plus iodine, to form allyl iodide, CH2 : CHCH2I, which with hydrogen iodide yields propylene, CH2 : CHCH3, and then iso-propyl iodide, CH3CHICH3, (5) with sodium or sodium hydroxide to form alcoholates, (6) with sodium hydrogen sulfate or phosphorus pentoxide heated, to form acrolein, CH2 : CHCHO. Glycide alcohol is obtained by treatment of glycerol alphamonochlorohydrin CH2OH·CHOH·CH2Cl, which is made by reaction of hypochlorous acid and allyl alcohol with barium hydroxide. With hydrogen chloride, glycide alcohol yields epichlorohydrin.

• Aroma threshold values

  Greater than 20,000 ppm.

• Synthesis Reference(s)

  Tetrahedron Letters, 32, p. 187, 1991 DOI: 10.1016/0040-4039(91)80850-6

• Allgemeine Beschreibung

  A colorless to brown colored liquid. Combustible but may require some effort to ignite. Residual sodium hydroxide (lye) causes crude material to be corrosive to metals and/or tissue.

• Air & Water Reaktionen

  Hygroscopic. Water soluble.

• Reaktivität anzeigen

  GLYCERINE is incompatible with strong oxidizers. Glycerol is also incompatible with hydrogen peroxide, potassium permanganate, nitric acid + sulfuric acid, perchloric acid + lead oxide, acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, F2 + PbO, KMnO4, K2O2, AgClO4 and NaH. A mixture with chlorine explodes if heated to 158-176° F. Glycerol reacts with acetic acid, potassium peroxide, sodium peroxide, hydrochloric acid, (HClO4 + PbO) and Na2O2. Contact with potassium chlorate may be explosive. Glycerol also reacts with ethylene oxide, perchloric acid, nitric acid + hydrofluoric acid and phosphorus triiodide.

• Health Hazard

  No hazard

• Brandgefahr

  Glycerol is combustible.

• Chemische Reaktivität

  Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

• Pharmazeutische Anwendungen

  Glycerin is used in a wide variety of pharmaceutical formulations including oral, otic, ophthalmic, topical, and parenteral preparations.
  In topical pharmaceutical formulations and cosmetics, glycerin is used primarily for its humectant and emollient properties. Glycerin is used as a solvent or cosolvent in creams and emulsions. Glycerin is additionally used in aqueous and nonaqueous gels and also as an additive in patch applications. In parenteral formulations, glycerin is used mainly as a solvent and cosolvent.
  In oral solutions, glycerin is used as a solvent, sweetening agent, antimicrobial preservative, and viscosity-increasing agent. It is also used as a plasticizer and in film coatings.
  Glycerin is used as a plasticizer of gelatin in the production of soft-gelatin capsules and gelatin suppositories.
  Glycerin is employed as a therapeutic agent in a variety of clinical applications, and is also used as a food additive.

• Biochem/physiol Actions

  Glycerol is hygroscopic in nature and is soluble in water owing to its three hydrophilic alcoholic hydroxyl groups. It can form both inter- and intramolecular hydrogen bonds, making it a very flexible molecule. The physiologic effect of glycerine is due to cell-mediated immunity, increased IgG production and increased histamine release.

• Sicherheitsprofil

  Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate, calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceql nitrate. Mixture with perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to 70-80'. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, Cr03,Cr203, F2 + PbO, phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.

• Sicherheit(Safety)

  Glycerin occurs naturally in animal and vegetable fats and oils that are consumed as part of a normal diet. Glycerin is readily absorbed from the intestine and is either metabolized to carbon dioxide and glycogen or used in the synthesis of body fats.
  Glycerin is used in a wide variety of pharmaceutical formulations including oral, ophthalmic, parenteral, and topical preparations. Adverse effects are mainly due to the dehydrating properties of glycerin.
  Oral doses are demulcent and mildly laxative in action. Large doses may produce headache, thirst, nausea, and hyperglycemia. The therapeutic parenteral administration of very large glycerin doses, 70–80 g over 30–60 minutes in adults to reduce cranial pressure, may induce hemolysis, hemoglobinuria, and renal failure.( 16) Slower administration has no deleterious effects.
  Glycerin may also be used orally in doses of 1.0–1.5 g/kg bodyweight to reduce intraocular pressure.
  When used as an excipient or food additive, glycerin is not usually associated with any adverse effects and is generally regarded as a nontoxic and nonirritant material.
  LD50 (guinea pig, oral): 7.75 g/kg
  LD50 (mouse, IP): 8.70 g/kg
  LD50 (mouse, IV): 4.25 g/kg
  LD50 (mouse, oral): 4.1 g/kg
  LD50 (mouse, SC): 0.09 g/kg
  LD50 (rabbit, IV): 0.05 g/kg
  LD50 (rabbit, oral): 27 g/kg
  LD50 (rat, IP): 4.42 g/kg
  LD50 (rat, oral): 5.57 g/kg
  LD50 (rat, oral): 12.6 g/kg
  LD50 (rat, SC): 0.1 g/kg

• Synthese

  Obtained from oils and fats as a by-product in the manufacture of soaps and fatty acids; synthesized from propylene; also production from sugars by fermentation.

• mögliche Exposition

  Glycerol is used as a humectant in tobacco; it is used in cosmetics, antifreezes and inks. It is used as a fiber lubricant. It is used as a raw material for alkyd resins and in explosives manufacture.

• Environmental Fate

  Glycerol is completely miscible with water. When exposed to moist air, it absorbs water (hydroscopic) as well as gasses such as hydrogen sulfide and sulfur dioxide. Glycerol has low volatility, with a vapor pressure of 0.000106 hPa at 25 ℃; the calculated Henry’s law constant (maximum solubility) is 9.75E^-6 Pam³ mol^-1. The calculated photodegradation halflife of glycerol in air is 6.8 h. Glycerol is readily biodegradable. When released to the environment, glycerol is distributed to water, with negligible amounts distributed in air, soil, or sediment. Based on a log Kow of ^-1.76, glycerol has a low bioaccumulation potential and is not expected to bioaccumulate.

• Lager

  Glycerin is hygroscopic. Pure glycerin is not prone to oxidation by the atmosphere under ordinary storage conditions, but it decomposes on heating with the evolution of toxic acrolein. Mixtures of glycerin with water, ethanol (95%), and propylene glycol are chemically stable.

• Versand/Shipping

  UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required.

• Toxicity evaluation

  The medicinal actions of glycerol are due to osmotic action; orally, 75 ml of glycerol is equivalent to 996 mosmol. Large intravenous doses of glycerol can cause hemolysis, hemoglobinuria, and subsequent renal failure. The osmotic effect of glycerol can lead to tissue dehydration and decreased cerebrospinal fluid pressure. Certain medical conditions such as cardiac, renal, or liver disease and/or diabetes mellitus may be exacerbated by shifts in body water as a result of oral, intravenous, or rectal (suppositories) administration of glycerol. No systemic effects have been reported following the application of large amounts of glycerol to the skin.

• Inkompatibilitäten

  Glycerin may explode if mixed with strong oxidizing agents such as chromium trioxide, potassium chlorate, or potassium permanganate. In dilute solution, the reaction proceeds at a slower rate with several oxidation products being formed. Black discoloration of glycerin occurs in the presence of light, or on contact with zinc oxide or basic bismuth nitrate.
  An iron contaminant in glycerin is responsible for the darkening in color of mixtures containing phenols, salicylates, and tannin.
  Glycerin forms a boric acid complex, glyceroboric acid, that is a stronger acid than boric acid.

• Inkompatibilitäten

  Able to polymerize above 300 ℉/150 ℃.Incompatible with acetic anhydrides (especially in the pres ence of a catalyst), strong acids, caustics, aliphatic amines, and isocyanates. Strong oxidizers, e.g., chromium trioxide, potassium chlorate, and potassium permanganate); can cause fire and explosion hazard. Hygroscopic (i.e., absorbs moisture from the air). Decomposes when heated, produc ing corrosive gas of acrolein.

• Waste disposal

  Mixture with a more flamma ble solvent followed by incineration.

• Regulatory Status

  GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental pastes; buccal preparations; inhalations; injections; nasal and ophthalmic preparations; oral capsules, solutions, suspensions and tablets; otic, rectal, topical, transdermal, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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