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Seratrodast Basic information
Seratrodast Chemical Properties
  • Melting point:118-120°C
  • Boiling point:522.3±49.0 °C(Predicted)
  • Density 1.140±0.06 g/cm3(Predicted)
  • storage temp. Store at +4°C
  • pka4.76±0.10(Predicted)
  • form Yellow-orange solid.
  • Merck 14,8459
  • CAS DataBase Reference112665-43-7(CAS DataBase Reference)
Safety Information
  • RTECS DA1600050
Seratrodast Usage And Synthesis
  • DescriptionSeratrodast, a novel benzoquinone derivative, is the first thromboxane A2 (TxA2) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA2, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles. Seratrodast potently inhibits platelet aggregation and bronchoconstriction induced by a TxA2 mimic and by a variety of spasmogenic prostanoids including PGF, PGD2 and 9α,11β-PGF2. Seratrodast shows excellent efficacy in asthma and has been reported to be potentially useful in hyper-responsive disorder. The R-(+)- seratrodast was reported to be the active isomer.
  • Chemical PropertiesPale Orange Solid
  • OriginatorTakeda (Japan)
  • Usesantibacterial
  • UsesThromboxane A2-receptor antagonist. Antiasthmatic
  • brand nameBronica
  • Biological ActivityThromboxane A 2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA 2 mimetic in guinea pigs.
Seratrodast Preparation Products And Raw materials
Seratrodast(112665-43-7)Related Product Information
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
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  • Tel:021-20908456-
  • Company Name:TCI (Shanghai) Development Co., Ltd.
  • Tel:021-67121386 / 800-988-0390
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  • Tel:13817811078,021-50426030