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Cyclophosphamide monohydrate

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Cyclophosphamide monohydrate Basic information
Cyclophosphamide monohydrate Chemical Properties
  • Melting point:49-51 °C(lit.)
  • Flash point:>230 °F
  • storage temp. 2-8°C
  • solubility H2O: 0.1 g/mL, clear, colorless
  • form Crystals or Crystalline Powder
  • color White to almost white
  • Water Solubility 40 g/L
  • Merck 14,2747
  • BRN 8167897
  • CAS DataBase Reference6055-19-2(CAS DataBase Reference)
  • IARC1 (Vol. 26, Sup 7, 100A) 2012
  • EPA Substance Registry SystemCyclophosphamide monohydrate (6055-19-2)
Safety Information
Cyclophosphamide monohydrate Usage And Synthesis
  • Chemical PropertiesWhite to Off-White Solid
  • UsesIt is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.
  • Usesantineoplastic, alkylating agent
  • Usesalkylating agent in cancer therapy
  • UsesAn immunosuppressive, cytotoxic apoptosis inducer.
  • DefinitionChEBI: The monohydrate of cyclophosphamide.
  • brand nameCytoxan (Bristol-Myers Squibb); Neosar (Sicor).
  • General DescriptionFine white crystalline powder with a slightly bitter taste. Little or no odor.
  • Air & Water ReactionsWater soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.
  • Reactivity ProfilePolymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.
  • Fire HazardCyclophosphamide monohydrate is probably combustible.
  • Safety ProfileConfirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.
Cyclophosphamide monohydrate Preparation Products And Raw materials
Cyclophosphamide monohydrate(6055-19-2)Related Product Information
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