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Pemirolast potassium

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Pemirolast potassium Basic information
Pemirolast potassium Chemical Properties
  • Melting point:310-311°C (dec.)
  • storage temp. -20°C Freezer, Under Inert Atmosphere
  • solubility H2O: ≥18mg/mL
  • form powder
  • color light yellow to yellow with a green cast
  • Merck 14,7078
  • CAS DataBase Reference100299-08-9(CAS DataBase Reference)
Safety Information
  • WGK Germany 3
  • RTECS UV1164470
Pemirolast potassium Usage And Synthesis
  • DescriptionPemirolast potassium is a new potent antiallergic mast cell stabilizer with a similar mechanism to sodium cromoglycate. Its main indication is bronchial asthma. Another indication under investigation is as a gastroprotective agent.
  • Chemical PropertiesCrystalline Solid
  • OriginatorBristol-Myers Squibb (U.S.A.)
  • UsesInhibitor of chemical mediator release from tissue mast cells. Antiallergic
  • UsesPemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent
  • brand nameAlamast (Sanofi Winthrop);Pemilaston;Alegysal.
  • General DescriptionPemirolast potassium, 9-methyl-3-(1H-tetrazol-5-yl)-4Hpyrido[1, 2- ]pyrimidin-4-one potassium (Alamast), is ayellow, water-soluble powder. It can be considered an analogof one portion of the cromolyn structure in which thecarboxyl group has been replaced with an isosteric tetrazolemoiety. Pemirolast is indicated for the prevention ofitching of the eye caused by allergic conjunctivitis. Thecommercial preparation is available as a 0.1% sterile ophthalmicsolution for topical administration to the eyes.Each milliliter of this solution contains 1 mg of pemirolastpotassium, as well as the preservative lauralkonium chloride(0.005%), and glycerin, phosphate buffers,and sodium hydroxide to maintain a solution pH of8.0. The solution has an osmolality of 240 mOsm/L. Therecommended dose is 1 to 2 drops instilled into each affectedeye 4 times a day. This drug product is for ocularadministration only and not for injection or oral use andshould be used with caution during pregnancy or whilenursing.
Pemirolast potassium(100299-08-9)Related Product Information
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