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Tetrazole Basic information
Tetrazole Chemical Properties
  • Melting point:156-158°C
  • Boiling point:220℃
  • Density 0.798 g/mL at 20 °C
  • refractive index n20/D 1.348
  • RTECS UW7370000
  • Flash point:5 °C
  • storage temp. Room temperature.
  • form Liquid
  • pka4.9(at 25℃)
  • color Cream to orange
  • Water Solubility Soluble
  • Decomposition 220°C
  • BRN 105799
  • CAS DataBase Reference288-94-8(CAS DataBase Reference)
  • NIST Chemistry Reference1H-Tetrazole(288-94-8)
  • EPA Substance Registry System1H-Tetrazole (288-94-8)
Safety Information
Tetrazole Usage And Synthesis
  • DescriptionTetrazole is a class of synthetic organic heterocyclic compound containing a 5-member ring of four nitrogen atoms and one carbon atom. It appears as an odorless white to light-yellow crystalline powder. It has several pharmaceutical applications. Tetrazole compound can act as a bioisotere for the carboxylate group, angiotensin II receptor blockers such as losartan and candesartan as well as dimethyl thiazolyl diphenyl tetrazolium bromide (MTT), which can be used in MTT assay for quantifying the respiratory activity of liver cells. It can also be used in DNA assays. In addition, Tetrazole derivatives have also been used in explosives such as TNT or high performance solid rocket propellant formulations. Tetrazole can be synthesized through the reaction between anhydrous hydrazoic acid and hydrogen cyanide under pressure.
  • References
  • Chemical Propertieswhite crystals or crystalline powder
  • UsesA catalyst for phosphoramidite synthesis.
  • DefinitionChEBI: A tetrazole tautomer where the proton is located on the 1st position.
  • General DescriptionTetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
  • Health HazardFire may produce irritating, corrosive and/or toxic gases.
  • Purification MethodsCrystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]
Tetrazole Preparation Products And Raw materials
Tetrazole(288-94-8)Related Product Information
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