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Fexofenadine hydrochloride

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Fexofenadine hydrochloride Basic information
Fexofenadine hydrochloride Chemical Properties
  • Melting point:148-150oC
  • RTECS CY1633377
  • storage temp. −20°C
  • solubility Soluble in Dimethyl sulfoxide (50 mM), and methanol.
  • form powder
  • color white to beige
  • Merck 14,4068
  • CAS DataBase Reference153439-40-8(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • HS Code 2933399090
Fexofenadine hydrochloride Usage And Synthesis
  • DescriptionFexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of selectively peripheral H1 blocker. Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors, thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness.
  • References
  • Chemical PropertiesOff-White Crystalline Solid
  • UsesA metabolite of of terfenadine, a H1-Histamine receptor antagonist
  • UsesThe active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.
  • UsesAntihistaminic;histamine H1-receptor antagonist
  • UsesFexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical]
  • General DescriptionFexofenadine hydrochloride, (±)-4-[1-hydroxy-4-[4-(hydroxyldiphenylmethyl)- 1-piperinyl]butyl-α,α-dimethylbenzeneacetic acid (Allegra), occurs as a white to off-white crystalline powder that is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane.
    This compound is marketed as a racemate and exists as a zwitterion in aqueous media at physiological pH. Fexofenadine is a primary oxidative metabolite of terfenadine. Terfenadine was developed during a search for new butyrophenone antipsychotic drugs as evidenced by the presence of the N-phenylbutanol substituent. It also contains a diphenylmethyl-piperidine moiety analogous to that found in the piperazine antihistamines.
  • Biological ActivitySelective histamine H 1 receptor antagonist (pK i = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.牋.
Fexofenadine hydrochloride (153439-40-8)Related Product Information
Fexofenadine hydrochloride SupplierMore
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
  • Products Intro:Product Name:Fexofenadine hydrochloride;α,α-DiMethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-benzeneaceticacidhydrochloride
    Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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  • Products Intro:Product Name:Fexofenadine Hydrochloride
    Purity:99% Package:1g;5g