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tert-Butyldimethylsilyl chloride

Basic information Introduction Safety Related Supplier
tert-Butyldimethylsilyl chloride Basic information
tert-Butyldimethylsilyl chloride Chemical Properties
  • Melting point:86-89 °C
  • Boiling point:125 °C(lit.)
  • Density 0.87 g/mL at 20 °C(lit.)
  • refractive index n20/D 1.46
  • Flash point:73 °F
  • storage temp. Store at 5°C
  • form Liquid
  • color Clear colorless
  • Specific Gravity1.225
  • Water Solubility Soluble in chloroform and ethyl acetate. Insoluble in water.
  • Sensitive Moisture Sensitive
  • Hydrolytic Sensitivity7: reacts slowly with moisture/water
  • Hydrolytic Sensitivity8: reacts rapidly with moisture, water, protic solvents
  • BRN 505999
  • CAS DataBase Reference18162-48-6(CAS DataBase Reference)
  • NIST Chemistry ReferenceSilane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
  • EPA Substance Registry SystemSilane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)
Safety Information
tert-Butyldimethylsilyl chloride Usage And Synthesis
  • IntroductionTriethylchlorosilane is a clear, colourless to yellowish, pungent smelling, caustic and flammable liquid. It can be dissolved in non-protonating solvents without decomposition.
    It may be used as silylating agent for dervatization of primary and secondary alcohols etc.. Also it may be used to protect allylic esters as silylketene acetal which is ore stable but less volatile derivates than trimethylchlorosilane.
  • Chemical PropertiesWhite solid
  • UsesUsed to protect alcohols during organic synthesis.
  • DefinitionChEBI: A silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry ap lications.
  • HazardModerately toxic.
  • Purification MethodsFractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]
tert-Butyldimethylsilyl chloride Preparation Products And Raw materials
tert-Butyldimethylsilyl chloride(18162-48-6)Related Product Information
tert-Butyldimethylsilyl chlorideSupplierMore
  • Company Name:Nanjing Apicci Pharmaceutical Technology Co., Ltd. Gold
  • Tel:18061682508
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  • Tel:86-576-88550069 13486888296
  • Company Name:Wuhan Heshun Technology Co., Ltd. Gold
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