ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Siloxane > (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
- Product Name:(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one
- CAS:76855-69-1
- MF:C13H25NO4Si
- MW:287.43
- EINECS:408-050-9
- Mol File:76855-69-1.mol
-
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Chemical Properties
- Melting point:107-109 °C(lit.)
- alpha 51 º (c=1, chloroform)
- Boiling point:358.3±27.0 °C(Predicted)
- Density 1.03±0.1 g/cm3(Predicted)
- storage temp. 2-8°C
- pka12.86±0.60(Predicted)
- optical activity[α]20/D +51°, c = 1 in chloroform
- InChIKeyGWHDKFODLYVMQG-UBHAPETDSA-N
- CAS DataBase Reference76855-69-1(CAS DataBase Reference)
- Hazard Codes Xi,N
- Risk Statements 36-43-51/53
- Safety Statements 24-26-37-61
- RIDADR UN 3077 9/PG 3
- WGK Germany 2
- HazardClass 9
- PackingGroup III
- HS Code 29337900
- Language:EnglishProvider:SigmaAldrich
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Usage And Synthesis
- Chemical Propertieswhite to light yellow crystal powde
- Uses(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one is an acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.
- Purification MethodsPurify it by chromatography on silica gel (3 x 14cm) for 50g of ester using 20% EtOAc in n-hexane. The eluate is evaporated, and the residue is recrystallised from hexane (white fluffy crystals). [Leanza et al. Tetrahedron 39 2505 1983.]
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Preparation Products And Raw materials
- Raw materialsEtanolHydrochloric acidMethanolDichloromethanePotassium hydroxide Acetic anhydrideTriethylaminePalladiumAcetonitrileHydrogenTriethyl orthoformateEthyl acetoacetateSodium hypochloriteOxygentert-Butylamine(R)-(+)-1,1'-Bi-2-naphtholBenzamidetert-Butyldimethylsilyl chloride(R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl1,5-Cyclooctadiene(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANERuthenium trichloride2-Mercaptothiazoline
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)Related Product Information
- Ethylbenzene ISOPROPOXYTRIMETHYLSILANE 3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL (3R,4R)-4-ACETOXY-3-[(3R)-1-(BUTYLDIMETHYL-SILYOXY)-ETHYL]-2-AZETIDIONE (AZETIDIN-3-YL)METHANOL T-BUTYLDIMETHYLSILANE 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL 4-Acetoxy-2-azetidinone TERT-BUTYLDIMETHYLSILANOL (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Benzyloxyacetyl chloride 1-Methyl-2-pyrrolidinone Ethyl formate Ethyl propionate Ethyl acrylate Ethylparaben 2-Butanone oxime Sodium triacetoxyborohydride
(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-oneSupplierMore
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