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Dilthiazem hydrochloride

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Dilthiazem hydrochloride Basic information
Dilthiazem hydrochloride Chemical Properties
Safety Information
  • Hazard Codes Xn,Xi,F
  • Risk Statements 22-40-36/37/38-36-20/21/22-11
  • Safety Statements 36-45-36/37-26-16
  • RIDADR 3249
  • WGK Germany 3
  • RTECS DL0310000
  • 8-10
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29349990
  • ToxicityLD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
MSDS
Dilthiazem hydrochloride Usage And Synthesis
  • Chemical PropertiesFine Needles
  • UsesAn antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils
  • UsesA calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
  • Usesantihypertensive, sedative, antibacterial
  • UsesPeripheral Vasodilator
  • DefinitionChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension.
  • brand nameCardizem (Biovail); Cartia (Andrx); Dilacor (Watson); Diltzac (Apotex); Taztia (Andrx); Tiazac (Biovail).
  • General DescriptionDiltiazem hydrochloride,(+)-cis-3-(acetoxy)-5-[2(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)1,5-benzothiazepin-4(5H)one hydrochloride(Cardizem), was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
    The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.
  • Biological ActivityAntihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.
Dilthiazem hydrochloride Preparation Products And Raw materials
Dilthiazem hydrochloride(33286-22-5)Related Product Information
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