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Dilthiazem hydrochloride

Dilthiazem hydrochloride Structure
Dilthiazem hydrochloride
  • CAS No.33286-22-5
  • Chemical Name:Dilthiazem hydrochloride
  • CBNumber:CB7302994
  • Molecular Formula:C22H27ClN2O4S
  • Formula Weight:450.98
  • MOL File:33286-22-5.mol
Dilthiazem hydrochloride Property
Safety
  • Hazard Codes  :Xn,Xi,F
  • Risk Statements  :22-40-36/37/38-36-20/21/22-11
  • Safety Statements  :36-45-36/37-26-16
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS  :DL0310000
  • F  :8-10
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29349990
  • Toxicity :LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H302+H312+H332-H319-H302-H315-H312
  • Precautionary statements P264-P270-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P210-P261-P302+P352+P312-P304+P340+P312-P337+P313-P403+P235-P301+P312+P330-P280h-P301+P312a-P321-P501a
Dilthiazem hydrochloride Price More Price(15)
  • Brand: Sigma-Aldrich
  • Product number: 309866
  • Product name : Diltiazem, Hydrochloride
  • Purity: Synthetic benzothiazepine that acts as an L-type Ca
  • Packaging: 100mg
  • Price: $75.2
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1205003
  • Product name : Diltiazem hydrochloride
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $352.8
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D3662
  • Product name : (+)-cis-Diltiazem Hydrochloride
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 5g
  • Price: $77
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D3662
  • Product name : (+)-cis-Diltiazem Hydrochloride
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 25g
  • Price: $269
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63245
  • Product name : (+)-cis-Diltiazem hydrochloride
  • Purity: 
  • Packaging: 5g
  • Price: $102
  • Updated: 2020/06/24
  • Buy: Buy

Dilthiazem hydrochloride Chemical Properties,Usage,Production

  • Chemical Properties Fine Needles
  • Uses An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils
  • Uses A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
  • Uses antihypertensive, sedative, antibacterial
  • Uses Peripheral Vasodilator
  • Definition ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension.
  • brand name Cardizem (Biovail); Cartia (Andrx); Dilacor (Watson); Diltzac (Apotex); Taztia (Andrx); Tiazac (Biovail).
  • General Description Diltiazem hydrochloride,(+)-cis-3-(acetoxy)-5-[2(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)1,5-benzothiazepin-4(5H)one hydrochloride(Cardizem), was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
    The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.
  • Biological Activity Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.
Dilthiazem hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global(258)Suppliers
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