ChemicalBook > Product Catalog > Organic Chemistry > Carboxylic acids and derivatives > Carboxylic acid esters and derivatives > Ethyl cyanoacetate
Ethyl cyanoacetate Chemical Properties
- Melting point:-22 °C (lit.)
- Boiling point:208-210 °C (lit.)
- Density 1.063 g/mL at 25 °C (lit.)
- vapor density 3.9 (vs air)
- vapor pressure 1 mm Hg ( 67.8 °C)
- refractive index n
- Flash point:>230 °F
- storage temp. Store below +30°C.
- solubility 20g/l
- form Liquid
- color Clear
- Water Solubility 20 g/L (20 ºC)
- Merck 14,3786
- BRN 605871
- CAS DataBase Reference105-56-6(CAS DataBase Reference)
- NIST Chemistry ReferenceAcetic acid, cyano-, ethyl ester(105-56-6)
- EPA Substance Registry SystemEthyl cyanoacetate (105-56-6)
Ethyl cyanoacetate Usage And Synthesis
- Chemical PropertiesEthyl cyanoacetate is a colorless to straw colored liquid with a mild pleasant odor
- UsesReagent used in labelled pyrimidine and purine synthesis. Ethyl cyanoacetate is an ester. It may be used in the synthesis of ethyl glyoxylate.It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.
- PreparationEthyl cyanoacetate can be prepared by the action of sodium or potassium cyanide on ethyl chloroacetate, and by the action of sodium cyanide on sodium chloroacetate, followed by esterification.
- General DescriptionA colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 210°F. May be toxic by ingestion. Used to make other chemicals.
- Air & Water ReactionsSlightly soluble in water.
- Reactivity ProfileEthyl cyanoacetate is both a nitrile and an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
- HazardToxic by ingestion and inhalation.
- Health HazardTOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
- Fire HazardCombustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
- Safety Profileoison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Combustible when exposed to heat or flame; can react with oxidzing materials. Wdl react with water or steam to produce toxic and flammable vapors. To fight fire, use CO2, dry chemical. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of CN-. See also NITRILES.
- Potential ExposureA nitrile used to manufacture dyes, pharmaceuticals, and other chemicals.
- ShippingUN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
- Purification MethodsShake the ester several times with aqueous 10% Na2CO3, wash it well with water, dry with Na2SO4 and fractionally distil it. [Beilstein 2 IV 1889.]
- IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Reacts with moisture, water, and steam, forming toxic fumes.
- Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Ethyl cyanoacetate Preparation Products And Raw materials
- Raw materialsEtanolHydrochloric acidSulfuric acid Sodium cyanideChloroacetic acidEthyl chloroacetateChloroacetic acid sodium saltCyanoacetic acid
- Preparation ProductsEthyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate2-AMINO-5-ISOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTERDacarbazine2,4,7-Triamino-6-phenylpteridine2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDEAllopurinol5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER6-AMINO-2-MERCAPTO-PYRIMIDIN-4-OL3-AMINO-2,2-DIMETHYL-1-PROPANOLETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97%6-AMINO-3-METHYLURACIL2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER1,2,3,5-TETRAHYDRO-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE-4-ONE5,6-Diamino-1-methyluracil6-AMINO-2-METHYLTHIO-3-METHYLURACIL5-CYANO-6-HYDROXY-4-METHOXYMETHYL-2-METHYLPYRIDINEGUANINE SULFATE6-AMINO-1-METHYL-5-NITROSOURACIL6-CHLORO-5-CYANO-4-METHOXYMETHYL-3-NITRO-2-PICOLINEEthyl α-cyanoacrylate instantaneous adhesive2-CHLORO-4-METHYLQUINOLINE-3-CARBONITRILEETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE6-Amino-1-methyluracil2-Amino-4-trifluoromethylbenzonitrileETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER2-(4,6-diamino-1,3,5-triazin-2-yl)acetic acid5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER1-ETHYL-1-METHYLSUCCINIC ACID6-Aminouracil Disperse Yellow S-3GLAmiloride hydrochlorideETHYL 2-CYANO-3-METHYL-2-PENTENOATEETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate2-FORMAMIDINO-2-PHENYLDIAZOACETAMIDE HYDROCHLORIDE
- Tris(tribromoneopenthyl)phosphate Pregabalin Impurity 12 Pregabalin Impurity 31 L-Tartrate Pregabalin Impurity 5 Tartrate Pregabalin Impurity 19 Pregabalin Impurity 57 (E)-2-CYANO-5-METHYL-HEX-2-ENOIC ACID METHYL ESTER (E)-5-methylhex-2-enoic acid (1-NITROETHYL)BENZENE Pregabalin Impurity 23 Pregabalin Impurity 38 Pregabalin Impurity 60 Pregabalin-d4 Pregabalin Impurity 30 3-(2-Methylpropyl)pentanediamide (3S)-3-(Aminomethyl)-N,N-diethyl-5-methylhexanamide Pregabalin Impurity 48 Pregabalin Impurity 21
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