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Ethyl cyanoacetate

Ethyl cyanoacetate Structure
Ethyl cyanoacetate
  • CAS No.105-56-6
  • Chemical Name:Ethyl cyanoacetate
  • CBNumber:CB9852660
  • Molecular Formula:C5H7NO2
  • Formula Weight:113.11
  • MOL File:105-56-6.mol
Ethyl cyanoacetate Property
  • Melting point: :-22 °C
  • Boiling point: :208-210 °C(lit.)
  • Density  :1.063 g/mL at 25 °C(lit.)
  • vapor density  :3.9 (vs air)
  • vapor pressure  :1 mm Hg ( 67.8 °C)
  • refractive index  :n20/D 1.418(lit.)
  • Flash point: :>230 °F
  • storage temp.  :Store below +30°C.
  • solubility  :20g/l
  • pka :3.19±0.10(Predicted)
  • form  :Liquid
  • color  :Clear
  • Water Solubility  :20 g/L (20 ºC)
  • Merck  :14,3786
  • BRN  :605871
  • CAS DataBase Reference :105-56-6(CAS DataBase Reference)
  • FDA UNII :X9N006U0F8
  • NIST Chemistry Reference :Acetic acid, cyano-, ethyl ester(105-56-6)
  • EPA Substance Registry System :Ethyl cyanoacetate (105-56-6)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H302+H312+H332-H315-H319-H302-H312-H332
  • Precautionary statements P280-P261-P264-P270-P271-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P280a-P304+P340-P305+P351+P338-P405-P501a
Ethyl cyanoacetate Price More Price(10)
  • Brand: Sigma-Aldrich
  • Product number: E18425
  • Product name : Ethyl cyanoacetate
  • Purity: ≥98%
  • Packaging: 5g
  • Price: $33.8
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: E18425
  • Product name : Ethyl cyanoacetate
  • Purity: ≥98%
  • Packaging: 1kg
  • Price: $89.2
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C0441
  • Product name : Ethyl Cyanoacetate
  • Purity: >99.0%(GC)
  • Packaging: 25g
  • Price: $17
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C0441
  • Product name : Ethyl Cyanoacetate
  • Purity: >99.0%(GC)
  • Packaging: 500g
  • Price: $45
  • Updated: 2020/06/24
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  • Brand: Alfa Aesar
  • Product number: A11498
  • Product name : Ethyl cyanoacetate, 98+%
  • Purity: 
  • Packaging: 500g
  • Price: $46.6
  • Updated: 2020/06/24
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Ethyl cyanoacetate Chemical Properties,Usage,Production

  • Chemical Properties Ethyl cyanoacetate is a colorless to straw colored liquid with a mild pleasant odor
  • Uses Reagent used in labelled pyrimidine and purine synthesis. Ethyl cyanoacetate is an ester. It may be used in the synthesis of ethyl glyoxylate.It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.
  • Preparation Ethyl cyanoacetate can be prepared by the action of sodium or potassium cyanide on ethyl chloroacetate, and by the action of sodium cyanide on sodium chloroacetate, followed by esterification.
  • General Description A colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 210°F. May be toxic by ingestion. Used to make other chemicals.
  • Air & Water Reactions Slightly soluble in water.
  • Reactivity Profile Ethyl cyanoacetate is both a nitrile and an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
  • Hazard Toxic by ingestion and inhalation.
  • Health Hazard TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
  • Fire Hazard Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
  • Safety Profile oison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Combustible when exposed to heat or flame; can react with oxidzing materials. Wdl react with water or steam to produce toxic and flammable vapors. To fight fire, use CO2, dry chemical. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of CN-. See also NITRILES.
  • Potential Exposure A nitrile used to manufacture dyes, pharmaceuticals, and other chemicals.
  • Shipping UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
  • Purification Methods Shake the ester several times with aqueous 10% Na2CO3, wash it well with water, dry with Na2SO4 and fractionally distil it. [Beilstein 2 IV 1889.]
  • Incompatibilities Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Reacts with moisture, water, and steam, forming toxic fumes.
  • Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Ethyl cyanoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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