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Methyl cyanoacetate

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Methyl cyanoacetate Basic information
Methyl cyanoacetate Chemical Properties
  • Melting point:-13 °C
  • Boiling point:204-207 °C(lit.)
  • Density 1.123 g/mL at 25 °C(lit.)
  • vapor density 3.41 (vs air)
  • vapor pressure 0.2 mm Hg ( 20 °C)
  • refractive index n20/D 1.417(lit.)
  • Flash point:>230 °F
  • storage temp. Store below +30°C.
  • solubility 54g/l
  • form Liquid
  • pka2.75±0.10(Predicted)
  • color Clear colorless to very slightly yellow
  • Water Solubility 54 g/L (20 ºC)
  • Sensitive Light Sensitive
  • BRN 773945
  • CAS DataBase Reference105-34-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceAcetic acid, cyano-, methyl ester(105-34-0)
  • EPA Substance Registry SystemAcetic acid, cyano-, methyl ester (105-34-0)
Safety Information
  • Hazard Codes Xi
  • Safety Statements 24/25
  • RIDADR 3276
  • WGK Germany 1
  • RTECS AG4375000
  • Hazard Note Irritant
  • TSCA Yes
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29269095
MSDS
Methyl cyanoacetate Usage And Synthesis
  • DescriptionMethyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.
  • Chemical Propertiesclear colorless to very slighlty yellow liquid
  • Usespharmaceutical intermediate
  • Purification MethodsPurify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]
Methyl cyanoacetate Preparation Products And Raw materials
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