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2-Cyanoacetamide

Basic information Uses Description Reference Safety Related Supplier
2-Cyanoacetamide Basic information
2-Cyanoacetamide Chemical Properties
  • Melting point:119-121 °C(lit.)
  • Boiling point:154.34°C (rough estimate)
  • Density 1,4 g/cm3
  • refractive index 1.5110 (estimate)
  • Flash point:419 °F
  • storage temp. Store below +30°C.
  • solubility cold water: soluble1gm in 6.5ml
  • pka-1.27±0.10(Predicted)
  • form Crystalline Powder
  • color White to light cream
  • OdorOdorless
  • Water Solubility soluble
  • Merck 14,2688
  • BRN 878221
  • CAS DataBase Reference107-91-5(CAS DataBase Reference)
  • NIST Chemistry ReferenceAcetamide, 2-cyano-(107-91-5)
  • EPA Substance Registry System2-Cyanoacetamide (107-91-5)
Safety Information
MSDS
2-Cyanoacetamide Usage And Synthesis
  • UsesCyanoacetamide has been used in photometric and fluorimetric postcolumn labeling.
  • Description2-Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum. Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence and is useful for the automated analysis of carbohydrates as borate complexes. It can also be used in the synthesis of heterocyclic compounds such as pyrazole, pyridine and pyrimidine derivatives. Moreover, it can also be applied for the spectrophotometric assay of the enzyme activity of cellulose in related host cells.
  • Reference
    1. El-Rady, Eman A., and M. A. Khalil. "2‐Cyanoacetamide in the Synthesis of Heterocyclic Compounds: Synthesis of New Polysubstituted Pyrazole, Pyridine and Pyrimidine Derivatives." Journal of the Chinese Chemical Society 51.4(2013):779-784.
    2. Jurick, W. M., Ii, et al. "Application of the 2-cyanoacetamide method for spectrophotometric assay of cellulase enzyme activity. " Plant Pathology Journal 11.1(2012):o234-o234.
  • Chemical PropertiesWHITE TO LIGHT CREAM CRYSTALLINE POWDER
  • UsesIn organic syntheses (e.g., starting material for vitamin B6 synthesis).
  • DefinitionA codon of glutamine that directs the placement of glutamine into a polypeptide.
  • Purification MethodsCrystallise the amide from MeOH/dioxane (6:4), then water and dry it over P2O5 under vacuum. [Beilstein 2 IV 1891.]
2-Cyanoacetamide Preparation Products And Raw materials
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