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Acetamide Basic information
Acetamide Chemical Properties
  • Melting point:78-80 °C(lit.)
  • Boiling point:221 °C(lit.)
  • Density 1.159
  • vapor pressure 1 mm Hg ( 65 °C)
  • refractive index 1.4274
  • Flash point:220-222°C
  • storage temp. Store at RT
  • solubility H2O: 0.5 g/mL, Hazen ≤50
  • pka0.63(at 25℃)
  • form Crystals
  • color White
  • OdorMousy odor
  • Water Solubility 2000 g/L (20 ºC)
  • Merck 14,43
  • JECFA Number1592
  • BRN 1071207
  • Stability:Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
  • CAS DataBase Reference60-35-5(CAS DataBase Reference)
  • IARC2B (Vol. 7, Sup 7, 71) 1999
  • NIST Chemistry ReferenceAcetamide(60-35-5)
  • EPA Substance Registry SystemAcetamide (60-35-5)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 40
  • Safety Statements 36/37
  • RIDADR UN 3077 9/PG 3
  • WGK Germany 1
  • RTECS AB4025000
  • 3
  • Autoignition Temperature560°C
  • TSCA Yes
  • HS Code 29241900
  • Hazardous Substances Data60-35-5(Hazardous Substances Data)
  • ToxicityLD50 orally in Rabbit: 7000 mg/kg
Acetamide Usage And Synthesis
  • DescriptionAcetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
    Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
    ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
  • Chemical PropertiesAcetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.
  • Chemical PropertiesAcetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.
  • Uses
    1. Acetamide is often used as plasticizer and as industrial solvent.
    2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
    3. Solubilizer.
    4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
    5. stabilizer.
    6. manufacture of methylamine, denaturing alcohol.
    7. In organic syntheses.
    8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
    9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.
  • UsesCryoscopy; organic synthesis; general solvent; lacquers; explosives, soldering flux; wetting agent; plasticizer
  • General DescriptionColorless crystals with a mousy odor (NTP, 1999). Low toxicity.
  • Air & Water ReactionsDeliquescent. Very soluble in water.
  • Reactivity ProfileAcetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).
  • Health HazardAfter oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.
  • Health HazardMild irritant; acute oral toxicity in animals very low; oral LD50 value (rats):7000 mg/kg; carcinogenic to animals; oraladministration caused blood and liver tumorsin mice and rats; carcinogenicity: animal limited evidence, no evidence in humans.
  • Fire HazardThe flash point of Acetamide has not been determined, but Acetamide is probably combustible.
  • Safety ProfileSuspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.
  • Potential ExposureUsed as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing
  • CarcinogenicityThe IARC has determined that there is sufficient evidence of carcinogenicity for acetamide in experimental animals and that it is possibly carcinogenic to humans.
  • storageAcetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.
  • ShippingUN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
  • Purification MethodsAcetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]
  • IncompatibilitiesReacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.
  • Waste DisposalAdd to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.
  • PrecautionsDuring handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.
Acetamide Preparation Products And Raw materials
Acetamide(60-35-5)Related Product Information
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