Basic information Description Physical Properties Toxicity Absorption, Distribution and Excretion Uses References Safety Related Supplier
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Cymoxanil

Basic information Description Physical Properties Toxicity Absorption, Distribution and Excretion Uses References Safety Related Supplier
Cymoxanil Basic information
Cymoxanil Chemical Properties
Safety Information
  • Hazard Codes Xn;N,N,Xn
  • Risk Statements 22-43-50/53
  • Safety Statements 36/37-60-61
  • RIDADR UN 3077
  • WGK Germany 3
  • RTECS AB5957000
  • HazardClass 9
  • PackingGroup III
  • HS Code 29269090
  • Hazardous Substances Data57966-95-7(Hazardous Substances Data)
  • ToxicityFor 80% formulations, LD50 orally in male rats: 1425 mg/kg; dermally in male rabbits: >3000 mg/kg. LC50 orally in bobwhite quails, mallard ducks: 2847, >10000 ppm. LC50 (96 hr) in bluegill sunfish, rainbow trout (ppm): 13.5, 18.7 (Klopping, Delp).
Cymoxanil Usage And Synthesis
  • DescriptionCymoxanil was first introduced in 1977. It is an acetimide compound used as both a curative and preventative foliar fungicide. In Europe it is being sold for use on grapes, potatoes, tomatoes, hops, sugarbeets and other vegetable crops. Cymoxanil is currently not registered in the U.S. Cymoxanil is a fungicide used on crops including potatoes, tomatoes, and grapes. Cymoxanil is not registered for non-crop use in any country. Cymoxanil's mode of action is as a local systemic. It penetrates rapidly and when inside the plant, it cannot
    be washed off by rain. It controls diseases during the incubation period and prevents the appearance of damage on the crop. The fungicide is primarily active on fungi belonging to the Peronosporales order: Phytophthora, Plasmopara, and Peronospora.
  • Physical Properties

    Technical cymoxanil is a peach colored crystalline, odorless solid.

  • ToxicityTechnical cymoxanil has low acute toxicity. The acute oral LD50 is 960 mg/kg in rats. The acute dermal LD50 is >2,000 mg/kg in rabbits. The 4-hour rat inhalation LC50 is >5.06 mg/L. Minimal transient irritation of the skin and eyes was observed in rabbits. Cymoxanil did not cause skin sensitization in guinea pigs. Cymoxanil should be classified as Toxicity Category III for oral and dermal toxicity and Toxicity Category IV for inhalation toxicity and skin and eye irritation potential.
    Absorption, Distribution and Excretion
    Cymoxanil is rapidly absorbed and maximum concentrations in the blood and plasma is reached within 4 hours after dosing. Rapid and almost complete elimination of the administered radioactive dose was observed in urine and feces within 48 hours. Excretion is primarily by urine (64-75%), fecal (16-24%) and expired air (< 5%) of the administered dose. There is no significant difference in residue profiles or elimination rates between sexes, dose levels, or single or multiple dosing. No evidence of bioaccumulation was detected. DPX-T3217 is metabolized extensively and only trace level of the administered (14)C-cymoxanil was detected in the urine and feces.
  • Absorption, Distribution and Excretion

    Cymoxanil is rapidly absorbed and maximum concentrations in the blood and plasma is reached within 4 hours after dosing. Rapid and almost complete elimination of the administered radioactive dose was observed in urine and feces within 48 hours. Excretion is primarily by urine (64-75%), fecal (16-24%) and expired air (< 5%) of the administered dose. There is no significant difference in residue profiles or elimination rates between sexes, dose levels, or single or multiple dosing. No evidence of bioaccumulation was detected. DPX-T3217 is metabolized extensively and only trace level of the administered (14)C-cymoxanil was detected in the urine and feces.

  • Uses

    Efficient fungicide

  • References1. http://pmep.cce.cornell.edu/profiles/extoxnet/carbaryl-dicrotophos/cymoxanil-ext.html
    2. https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+112-31-2
    3. http://www.agchemaccess.com/Cymoxanil
  • Chemical PropertiesA white to peach (pale pink) crystalline solid.
  • UsesCymoxanil is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.
  • UsesAgricultural fungicide.
  • UsesCymoxanil is a foliar applied fungicide which provides preventive and curative control of pathogen species of the order Peronosporales (eg. Phytophthora, Plasmopara and Peronospora) in grapes, potatoes, tomatoes, hops, tobacco and cucurbits.
  • DefinitionChEBI: A member of the class of ureas that is urea in which the two nitrogen atoms are substituted by an ethyl group and a 2-cyano-2-(methoxyimino)acetyl group respectively. A fungicide used to control Peronosporales on a range of crops including vin s, hops and potatoes.
  • Agricultural UsesFungicide: Cymoxanil is applied as a seed treatment to cut potato seed pieces or as a foliar to control late blight.
  • Trade nameCURZATE®; DPX 3217®; DPX 3217 M®; DPX-T3217®; EVOLVE®; MZ-CURZATE®; TANOS® Cymoxanil
  • Contact allergensCymoxanil, an urea derivative, is included (10%) with dithianone (25%) in Aktuan?. It is a fungicide agent, possibly sensitizing agricultural workers
  • Potential ExposureCymoxanil is a cyanoacetamide oxime fungicide applied as a seed treatment to cut potato seed pieces or as a foliar to control late blight.
  • Metabolic pathwayCymoxanil is rapidly degraded in neutral to alkaline aqueous solutions and is metabolised extensively in soil, plants and animals. Cymoxanil degradation follows a series of cyclisation and /or hydrolysis reactions to form 5- and 6-membered ring compounds and shorter chain keto acids and amides. In plants and animals, cymoxanil is metabolised to form natural products, especially glycine.
  • ShippingUN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz- ardous material, Technical Name Required.
  • DegradationThe hydrolysis of cymoxanil is pH dependent. It degraded rapidly in alkaline solution at 25 °C with calculated DT50 values at pH 5,7 and 9, of 148 days, 34 hours and 31 minutes, respectively (PM). The principal hydrolysis products at pH 9 were 1-ethyldihydro-dimino-2,4,5(3H)- pyrimidinetrione 5-(O-methyloxime) (2), cyano(methoxyimino)acetic acid (3) and [[(ethylamino)carbonyl]amino]oxoacetic acid (4). Oxalic(5) and aminooxoacetic acid (6) were recovered as minor products. The principal degradation products at pH 7 were compounds 2 and 4. No hydrolytic products at pH 5 exceeded 10% of the applied radioactivity throughout the 30-day incubation (Lawler, 1996).
    Photolysis of cymoxanil occurred rapidly at pH 5 when irradiated under a xenon arc light source. The DT50 values of cymoxanil at 25 °C were 1.8 and 148 days, light exposed vs. dark control, respectively. 3-Ethyl-4- (methoxyamino)-2,5-dioxo-4-imidazolidinecarbonitrile(7) and 1-ethyl-imidazolidinetrione 5-(O-methyloxime) (8) were the major degradation products. Compounds 2, 4, 6 and ethylimidazolidinetrione (9) were also present as minor products (Anderson et al., 1993). The hydrolytic degradation and photolytic degradation pathways of cymoxanil are presented in Scheme 1.
  • IncompatibilitiesSlowly hydrolyzes in water, releasing ammonia and forming acetate salts. Light sensitive.
  • Waste DisposalDo not discharge into drains or sewers. Burn in incinerator specifically designed for pes- ticide disposal or dispose as a Hazardous waste in a landfill approved and licensed for the disposal of pesticides. Consult with environmental regulatory agencies for guid- ance on acceptable disposal practices. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on ani- mal, aquatic, and plant life; and conformance with environ- mental and public health regulations.
Cymoxanil Preparation Products And Raw materials
Cymoxanil(57966-95-7)Related Product Information
CymoxanilSupplierMore
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