SirReal2 (4 mg/kg, i.p., every 3 days for 28 days) combined with VS-5584 (4mg/kg, i.p., every 3 days for 28 days) leads to an extension of the survival time of mice and exhibits significant anti-tumor effects[3].
SirReal2 (50 mg/kg, i.p., every 3 days for 19 days) inhibits the expression of SIRT2, resumes NK cell tumor infltration and suppresses melanoma progression in WT mice[4].
| Animal Model: | mouse tumor xenograft model[3] |
| Dosage: | 4 mg/kg |
| Administration: | i.p., every 3 days for 28 days |
| Result: | Restrained the growth of subcutaneous xenografts combined with VS-5584 in vivo. |
