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Triethyl orthoformate

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Triethyl orthoformate Basic information
Triethyl orthoformate Chemical Properties
  • Melting point:-76 °C (lit.)
  • Boiling point:146 °C (lit.)
  • Density 0.891 g/mL at 25 °C (lit.)
  • vapor density 5.11 (vs air)
  • vapor pressure 2.9 mm Hg ( 20 °C)
  • refractive index n20/D 1.391(lit.)
  • Flash point:86 °F
  • storage temp. Flammables area
  • form Liquid
  • color Clear colorless
  • Water Solubility 1.35 g/L
  • Sensitive Moisture Sensitive
  • Merck 14,6884
  • BRN 605384
  • CAS DataBase Reference122-51-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceEthyl orthoformate(122-51-0)
  • EPA Substance Registry SystemEthyl orthoformate (122-51-0)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 10-36-36/38
  • Safety Statements 16-26-37/39-36-45-36/39
  • RIDADR UN 2524 3/PG 3
  • WGK Germany 1
  • RTECS RM6475000
  • 21
  • TSCA Yes
  • HazardClass 3
  • PackingGroup III
  • HS Code 29159080
  • ToxicityLD50 orally in rats: 7.06 g/kg (Smyth)
Triethyl orthoformate Usage And Synthesis
  • Chemical PropertiesColorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.
  • UsesLabelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740).
  • UsesA reagent useful for acetylization and imidic ester formation.
  • General DescriptionA clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.
  • Reactivity ProfileTriethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
  • HazardFlammable, moderate fire risk.
  • Health HazardMay cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
  • Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
  • Safety ProfileModerately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
  • Purification MethodsFractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.
Triethyl orthoformate Preparation Products And Raw materials
Triethyl orthoformate(122-51-0)Related Product Information
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