Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Nervous system drugs >  Sedative and hypnotic >  Urethane


Basic information Safety Related Supplier
Urethane Basic information
Urethane Chemical Properties
  • Melting point:48-50 °C(lit.)
  • Boiling point:182-184 °C(lit.)
  • Density 1.10
  • vapor density 3.07 (vs air)
  • vapor pressure 10 mm Hg ( 77.8 °C)
  • refractive index 1.4144
  • Flash point:198 °F
  • storage temp. Room temperature.
  • solubility slightly soluble
  • pka13.58±0.50(Predicted)
  • form Crystals or Crystalline Powder
  • color White
  • PHpH(50g/l, 25℃) : 5.0~7.0
  • Water Solubility slightly soluble
  • Merck 14,9874
  • BRN 635810
  • Stability:Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
  • CAS DataBase Reference51-79-6(CAS DataBase Reference)
  • IARC2A (Vol. 7, Sup 7, 96) 2010
  • NIST Chemistry ReferenceUrethane(51-79-6)
  • EPA Substance Registry SystemUrethane (51-79-6)
Safety Information
  • Hazard Codes T
  • Risk Statements 45-22
  • Safety Statements 53-45-99
  • RIDADR UN 3077 9 / PGIII
  • WGK Germany 3
  • RTECS FA8400000
  • TSCA Yes
  • HS Code 29241990
  • Hazardous Substances Data51-79-6(Hazardous Substances Data)
  • ToxicityMLD i.p. in mice: 2.1-2.2 g/kg (Franklin)
Urethane Usage And Synthesis
  • DescriptionEthyl carbamate occurs as colourless or white columnar crystals or granular powder. It is very soluble in water. With heat, ethyl carbamate undergoes decomposition and emits toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides. Ethyl carbamate is used as an intermediate in the synthesis of a number of chemical products, for example, pharmaceuticals, in biochemical research and medicine, and as a solubiliser and co-solvent for pesticides and fumigants. Prior to World War II, ethyl carbamate saw relatively heavy use in the treatment of multiple myeloma before it was found to be toxic, carcinogenic, and largely ineffective. However, due to U.S. FDA regulations, ethyl carbamate has been withdrawn from pharmaceutical use. However, small quantities of ethyl carbamate are also used in laboratories as an anaesthetic for animals.
  • Chemical PropertiesColorless crystals or white powder; odorless, saltpeter-like taste. Solutions neutral to litmus. Soluble in water, alcohol, ether, glycerol, and chloroform; slightly soluble in olive oil. Combustible.
  • Chemical PropertiesUrethane is a colorless, almost odorless crystalline solid or powder.
  • OccurrenceUrethane (ethyl carbamate) occurs as a natural byproduct in fermented products such as wine, liquors, yogurt, beer, bread, olives, cheeses, and soy sauces. Whereas urethane has a known cancer etiology in experimental animals, no such relationship has yet been proven in humans. Alcohol may act by blocking the metabolism of urethane, and thus exert a protective effect in humans consuming alcoholic beverages.
  • UsesThe primary use of urethane has been as a chemical intermediate in preparation of amino resins (IARC 1974). The process involves a reaction with formaldehyde to give hydroxymethyl derivatives that are used as cross-linking agents in permanent-press textile treatments designed to impart wash-and-wear properties to fabrics. Urethane isalso used as a solubilizer and co-solvent in the manufacture of pesticides, fumigants, and cosmetics, as an intermediate in the manufacture of pharmaceuticals, and in biochemical research (HSDB 2009). Urethane was formerly used as an active ingredient in drugs prescribed for the treatment of neoplastic diseases, as a sclerosing solution for varicose veins, as a hypnotic, and as a topical bactericide. It is also used in veterinary medicine as an anesthetic (IARC 1974). Urethane is produced naturally during many fermentation processes(Zimmerli and Schlatter 1991).
  • UsesNaturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen.
  • Usesantiinfective
  • UsesIntermediate in organic synthesis. In the preparation and modification of amino resins. As solvent, solubilizer and cosolvent for various organic materials. Animal anesthetic in laboratory procedures.
  • DefinitionA poisonous flammable organic compound, used in medicine, as a solvent, and as an intermediate in the manufacture of polyurethane resins.
  • World Health Organization (WHO)Urethane was formerly used as an antineoplastic agent in the treatment of chronic myeloid leukaemia. It is also a mild hypnotic which has been used as an anaesthetic for veterinary practice. It has been reported to have both a carcinogenic and mutagenic potential. Although urethane continues to be used as an industrial solvent, WHO has no information to suggest that it remains commercially available in pharmaceutical preparations.
  • General DescriptionOdorless colorless crystals or white powder. Sublimes readily at 217°F and 54 mm Hg. Cooling saline taste.
  • Air & Water ReactionsWater soluble. Aqueous solutions are neutral to litmus .
  • Reactivity ProfileUrethane is incompatible with alkalis, acids, chloral hydrate, camphor, menthol and thymol. Also incompatible with antipyrine and salol. May react with strong oxidizing agents. Liquefies with benzoic acid, resorcinol and salicylic acid. Reacts with phosphorus pentachloride to form an explosive product .
  • HazardToxic by ingestion.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. A transplacental carcinogen. Moderately toxic by ingestion, intraperitoneal, subcutaneous, intramuscular, parenteral, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Causes depression of bone marrow and occasionally focal degeneration in the brain. Can also produce central nervous system depression, nausea and vomiting. Has been found in over 1000 beverages sold in the United States. The most heavily contaminated liquors are bourbons, sherries, and fruit brandies (some had 1000 to 12,000 ppb urethane). Many whiskeys, table and dessert wines, brandies, and liqueurs contain potentially hazardous amounts of urethane. The allowable limit for urethane in alcoholic beverages is 125 ppb. It is formed as a side product during processing.Hot aqueous acids or alkalies decompose urethane to ethanol, carbon dioxide, and ammonia. Reacts with phosphorus pentachloride to form an explosive product. When heated it emits toxic fumes of NOx. Used as an intermedate in the manufacture of pharmaceuticals, pesticides, and fungicides. See also CARBAMATES.
  • Potential ExposureUrethane is used as a chemical intermediate in manufacture of pharmaceuticals; pesticides, and fungicides; in the preparation of amino resins. It may be reacted with formaldehyde to give cross-linking agents which impart wash-and-wear properties to fabrics. It has also been used as a solubilizer and cosolvent in the manufacture of pesticides, fumigants, and cosmetics. It was formerly used in the treatment of leukemia. It occurs when diethylpyrocarbonate, a preservative used in wines, fruit juices, and soft drinks, is added to aqueous solutions.
  • CarcinogenicityUrethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
  • Purification MethodsUrethane is best purified by fractional distillation, but it can be 20 25 1.4144. sublimed at ~103o/~50mm. It has also been recrystallised from *benzene. Its solubilitiy at room temperature is 2g/mL in H2O, 1.25g/mL in EtOH, 1.1g/mL in CHCl3, 0.67g/mL in Et2O and 0.03g/mL in olive oil. It is a suspected human carcinogen.[Beilstein 3 H 22, 3 IV 40.]
  • IncompatibilitiesDust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, gallium, perchlorate.
  • Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).
Urethane Preparation Products And Raw materials
Urethane(51-79-6)Related Product Information
  • Company Name:卡托研究化学公司 Gold
  • Tel:4000-868-328 020-81215950-
  • Company Name:Weifang Qianyuan Biotechnology Co., Ltd. Gold
  • Tel:18765609661
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:400-660-8290 21-61259100-
  • Company Name:future industrial shanghai co., ltd
  • Tel:400-0066-400
Related articles