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Tert-Butyldimethylsilyl chloride: Uses and hazard

Apr 24，2024

Description

Tert-butyldimethylsilyl chloride (TBDMSCl) is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl, and two methyl groups. It is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

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Uses

TBDMSCl is an organosilicon compound used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. It is also used to prepare isoxazoline N-oxides from α-bromonitroalkanes and olefins. TBDMSCl is a precursor that forms a silicon substrate for Ag/ZnO/graphene-based nanocomposites to create an effective photocatalytic system for hydrogen production.

Potential Health Effects

Tert-butyldimethylsilyl chloride is Dangerous! Flammable solid. Moisture sensitive. Causes eye and skin burns. Causes digestive and respiratory tract burns.

Target Organs: Eyes, skin, mucous membranes.

First Aid Measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower

Skin: Get medical aid immediately. Immediately flush skin with water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner that limits further exposure.

Ingestion: If the victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

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