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Name 1,2-Propanediol
CAS 57-55-6
EINECS(EC#) 200-338-0
Molecular Formula C3H8O2
MDL Number MFCD00064272
Molecular Weight 76.09
MOL File 57-55-6.mol

Chemical Properties

Appearance Propylene glycol is a colorless, odorless, syrupy liquid.
Melting point  -60 °C
Boiling point  187 °C(lit.)
density  1.036 g/mL at 25 °C(lit.)
vapor density  2.62 (vs air)
vapor pressure  0.08 mm Hg ( 20 °C)
FEMA  2940
refractive index  n20/D 1.432(lit.)
Fp  225 °F
storage temp.  Store at RT.
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form  Viscous Liquid
pka 14.49±0.20(Predicted)
color  APHA: ≤10
Specific Gravity 1.038 (20/20℃)1.036~1.040
Odor at 100.00 %. odorless very slight alcoholic
PH 6-8 (100g/l, H2O, 20℃)
explosive limit 2.4-17.4%(V)
Odor Type odorless
Water Solubility  miscible
Sensitive  Hygroscopic
JECFA Number 925
Merck  14,7855
BRN  1340498
Dielectric constant 32.0
Contact allergens
Propylene glycol is used as a solvent, a vehicle for topical medicaments such as corticosteroids or aciclovir, an emulsifier and humectant in food and cosmetics, and as antifreeze in breweries, in the manufactures of resins. It was present as an occupational sensitizer in the color film developer Flexicolor®. Patch tests in aqua are sometimes irritant.
LogP -0.92
Next to water, propylene glycol is the most common moisturecarrying vehicle used in cosmetic formulations. It has better skin permeation than glycerin, and it also gives a pleasant feel with less greasiness than glycerin. Propylene glycol is used as a humectant because it absorbs water from the air. It also serves as a solvent for anti-oxidants and preservatives. In addition, it has preservative properties against bacteria and fungi when used in concentrations of 16 percent or higher. There is a concern that propylene glycol is an irritant at high concentrations, though it appears to be quite safe at usage levels under 5 percent.
CAS DataBase Reference 57-55-6(CAS DataBase Reference)
NIST Chemistry Reference Propylene glycol(57-55-6)
EPA Substance Registry System 57-55-6(EPA Substance)

Safety Data

Safety Statements 
S24/25:Avoid contact with skin and eyes .
WGK Germany  1
RTECS  TY2000000
Autoignition Temperature 779 °F
HS Code  29053200
Safety Profile
Slightly toxic by ingestion, skin contact, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, convulsions, changes in surface EEG. Experimental teratogenic and reproductive effects. An eye and human skin irritant. Mutation data reported. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. May react with hydrofluoric acid + nitric acid + silver nitrate to form the explosive silver fulminate. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazardous Substances Data 57-55-6(Hazardous Substances Data)

Hazard Information

Material Safety Data Sheet(MSDS)

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