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77-86-1

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Identification

Name
Trometamol
CAS
77-86-1
Synonyms
2-AMINO-2-HYDROXYMETHYL
2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL
2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL
2-AMINO-(HYDROXYMETHYL)-1,3-PROPANEDIOL
2-HYDROXYMETHYL-2-AMINO-1,3-PROPANEDIOL
4G 1MTRIS, PH 8.0
8VTE 1L
AMINOMETHYLIDINE TRIMETHANOL
ATX TRIS BUFFER
BUFFER TRIS
MOLE-READY-TRIS BASE
SIGMA 7-9(R)
SPECTRIS(R)
SPECTRIS(TM)
THAM
TIMTEC-BB SBB006714
TRI(HYDROXYMETHYL)AMINOMETHANE
TRIMETHYLOL AMINOMETHANE
TRIS
TRISAMINE
EINECS(EC#)
201-064-4
Molecular Formula
C4H11NO3
MDL Number
MFCD00004679
Molecular Weight
121.14
MOL File
77-86-1.mol

Questions And Answer

Chemical Properties
White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
Uses of Biology
Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
Uses
1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.

Chemical Properties

Appearance
White crystalline powder
Appearance
White, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.
mp 
167-172 °C(lit.)

bp 
219-220 °C10 mm Hg(lit.)

density 
1,353 g/cm3
Fp 
219-220°C/10mm
storage temp. 
2-8°C

solubility 
H2O: 4 M at 20 °C, clear, colorless

form 
crystalline

color 
white

Stability:
Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
Water Solubility 
550 g/L (25 ºC)
Sensitive 
Hygroscopic
Detection Methods
T,MP
Detection Methods
T,NMR
Detection Methods
T,NMR,MS
Merck 
14,9772
BRN 
741883
Uses
tromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.
CAS DataBase Reference
77-86-1(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System
77-86-1(EPA Substance)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
WGK Germany 
2

RTECS 
TY2900000


3
HS Code 
29221980
Hazardous Substances Data
77-86-1(Hazardous Substances Data)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Spectrum Detail

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