616-30-8

Name	3-Amino-1,2-propanediol
CAS	616-30-8
EINECS(EC#)	210-475-8
Molecular Formula	C3H9NO2
MDL Number	MFCD00008140
Molecular Weight	91.11
MOL File	616-30-8.mol

Chemical Properties

Appearance	clear colorless to pale yellow viscous liquid
Melting point	55-57 °C
Boiling point	264-265 °C739 mm Hg(lit.)
density	1.175 g/mL at 25 °C(lit.)
vapor pressure	<1 hPa (20 °C)
refractive index	n20/D 1.492(lit.)
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	>1000g/l soluble
form	liquid (highly viscous)
pka	12.11±0.35(Predicted)
color	Clear colorless to pale yellow
Specific Gravity	1.175
PH	11 (100g/l, H2O, 20℃)
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	1719121
InChIKey	KQIGMPWTAHJUMN-UHFFFAOYSA-N
LogP	-2.079 (est)
CAS DataBase Reference	616-30-8(CAS DataBase Reference)
NIST Chemistry Reference	3-Amino-1,2-propanediol(616-30-8)
EPA Substance Registry System	616-30-8(EPA Substance)

Safety Data

Hazard Codes	C,Xi
Risk Statements	R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36:Wear suitable protective clothing . less more
RIDADR	UN 2735 8/PG 2
WGK Germany	2
RTECS	TY2800000
F	10-21
Hazard Note	Corrosive
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29221980
Toxicity	LD50 orally in Rabbit: 7500 mg/kg less more

Raw materials And Preparation Products

Hazard Information

Description

APD is a calcium metabolism regulator useful in the treatment of Paget's disease, tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic activity.

Chemical Properties

clear colorless to pale yellow viscous liquid

Originator

Henkel (W. Germany)

Application

(±)-3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery.

Uses

3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials.

Preparation

3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.

Brand name

Aminomux

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx.

storage

3-Amino-1,2-propanediol absorbs moisture and needs to be kept in a container sealed. Store in cool, dry conditions in well-sealed containers.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Saintchem Chemical Co., Ltd.

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Weifang QianJin Fine Chemical Co., Ltd.

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Wuhan EnTai Technology Development Co,.Ltd

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J & K SCIENTIFIC LTD.

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TCI (Shanghai) Development Co., Ltd.

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Websitehttps://www.tcichemicals.com/CN/zh/

ShangHai DEMO Chemical Co.,Ltd

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Websitehttp://www.demochem.com

Beijing HwrkChemical Technology Co., Ltd

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Websitehttp://www.hwrkchemical.com

Energy Chemical

Telephone021-021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Beijing Ouhe Technology Co., Ltd

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Websitehttp://www.ouhechem.com/

Jia Xing Isenchem Co.,Ltd

Telephone0573-85285100 18627885956

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList14265/0.htm

Zhejiang Jianfeng Haizhou Pharmaceutical Co., Ltd.

Telephone+86 (576) 88221016

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13708/0.htm

Accela ChemBio Co.,Ltd.

Telephone021-50795510 4000665055

Websitehttp://www.shao-yuan.com/

Nanjing Chemlin Chemical Co., Ltd

Telephone025-83697070

Websitehttp://www.echemlin.cn

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

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