General Description
A colorless liquid. Flash point near 89°F. Less dense than water. Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent.
Reactivity Profile
1-METHOXY-2-PROPANOL(107-98-2) is a methoxy alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Air & Water Reactions
Highly flammable. Soluble in water. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164].
Hazard
Flammable, moderate fire risk. TLV: 100
ppm; STEL 150 ppm.
Health Hazard
VAPOR: Irritating to eyes, nose, and throat. LIQUID: Irritating to skin and eyes.
Potential Exposure
Propylene glycol monomethyl ether is
used as a solvent for coatings; cellulose esters and acrylics;
acrylics dyes; inks, and stains. It may also be used as
a heat-transfer fluid.
Fire Hazard
FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash
immediately with soap and water. Seek medical attention
immediately. If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precau-
tions, including resuscitation mask) if breathing has stopped
and CPR if heart action has stopped. Transfer promptly to a
medical facility. When this chemical has been swallowed,
get medical attention. Give large quantities of water and
induce vomiting. Do not make an unconscious person vomit.
Shipping
UN3092 1-Methoxy-2-propanol, Hazard Class: 3;
Labels: 3-Flammable liquid.
Incompatibilities
Vapor may form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, acid chlorides, acid anhydrides, isocya-
nates, aluminum, and copper. Hygroscopic (i.e., absorbs
moisture from the air). May slowly form reactive peroxides
during prolonged storage or on exposure to air and light.
Chemical Properties
colourless liquid
Chemical Properties
Propylene glycol monomethyl ether is a color-
less liquid. Ethereal odor. The Odor Threshold is 10 ppm.
Chemical Properties
Propylene glycol monomethyl ether is a colorless liquid with a sweet ether-like
odor and bitter taste. It is soluble in water, ether, acetone, and benzene.
Waste Disposal
Dissolve or mix the
material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber.
All federal, state, and local environmental regulations must
be observed.
Uses
A glycol ether and a good biological indicator of exposure.
Uses
PGME is used as a solvent for cellulose, acrylics, dyes, inks, and cellophane.
Uses
Propylene glycol monomethyl ether is primarily used in the manufacture of
lacquers and paints, as an anti-freeze in industrial engines, a tailing agent for inks
used on very high-speed presses, a coupling agent for resins and dyes in waterbased
inks, and a solvent for celluloses, acrylics, dyes, inks, and stains. It is also
used in cleaning products such as glass and rug cleaners, carbon and grease
removers, and paint and varnish removers; and in pesticide formulations as a
solvent for applications to crops and animals.
Flammability and Explosibility
Flammable
Synthesis
1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes, which acts as a protein kinase C inhibitors. It is also used as a reagent in the synthesis of metolachlor.
Toxicity evaluation
Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. The oral LD50 of rats was 6.6g/kg. The skin irritation is not obvious, but the toxic dose can be absorbed through the skin. The main manifestations of animal poisoning were inhibition and incomplete anesthesia. Half of the rats died when they were exposed to steam concentration of 40.18g/m3 for 5 ~ 6 hours. the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German MAK-value (100ppm) and to the 10-fold concentration (1000ppm).
