ChemicalBook CAS DataBase List 64431-96-5

64431-96-5

Name	1,3-Bis[tris(hydroxymethyl)methylamino]propane
CAS	64431-96-5
EINECS(EC#)	264-899-3
Molecular Formula	C11H26N2O6
MDL Number	MFCD00004689
Molecular Weight	282.33
MOL File	64431-96-5.mol

Synonyms

1,3-BIS[TRIS(HYDROXYMETHYL)METHYLAMINO]PROPANE BIS-TRIS PROPANE Bis Tris propane 1,3-Bis[tris(hydroxymethyl)methylamino]propane bis-tris propane molecular biology*reagent BIS-Tris Propane, ULTROL Grade Bistrishydroxymethylmethylaminopropane 2,2'-(propane-1,3-diyldiimino)bis[2-(hydroxymethyl)propane-1,3-diol] BIS-TRIS PROPANE, BIOTECHNOLOGY PERFORMA NCE CERTIFI BIS-TRIS PROPANE SIGMAULTRA BIS-TRISPROPANE,BIOLOGICALBUFFER 1,3-Bis[tris(hydroxymethyl)methylamino]propane >99% 1,3-Bis[tris(hydroxymethyl)methylamino]propane, 98+% 1,3-Bis[tris(hydroxymethyl)methylamino]propane [for Buffer Material] 1,3-Bistris(hydroxymethyl)methylaminoüpropane, 98+% 2,2'-(1,3-Propanediylbisimino)bis[2-(hydroxymethyl)-1,3-propanediol] 2,2'-(1,3-Propanediyldiimino)bis[2-(hydroxymethyl)-1,3-propanediol] 2,2'-[1,3-Propanediylbis(imino)]bis[2-(hydroxymethyl)-1,3-propanediol] N,N'-(1,3-Propanediyl)bis[N-[1,1-bis(hydroxymethyl)-2-hydroxyethyl]amine] Trimethylenebis(iminomethanetetrayl)hexakismethanol

Chemical Properties

Melting point	164-165 °C(lit.)
Boiling point	573.3±50.0 °C(Predicted)
density	1.326±0.06 g/cm3(Predicted)
storage temp.	Store at RT.
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	Powder/Solid
color	White
PH	9.0-10.1 (20-25℃, 1M in water)
PH Range	6.3 - 9.5
pka	(1) 6.8, (2) 9.0(at 25℃)
biological source	synthetic
Water Solubility	Soluble in water.
BRN	1786109
Major Application	diagnostic assay manufacturing
InChI	InChI=1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2
InChIKey	HHKZCCWKTZRCCL-UHFFFAOYSA-N
SMILES	C(NC(CO)(CO)CO)CCNC(CO)(CO)CO
CAS DataBase Reference	64431-96-5(CAS DataBase Reference)
Absorption	≤0.05 at 290 at 30% (w/w)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
Hazard Codes	Xn
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
REACH Registrations	Active
HS Code	29221990
Storage Class	11 - Combustible Solids

Hazard Information

Description

BIS-TRIS Propane is Good′s buffer. It acts as ligand and forms series of dinuclear hydroxo complexes with Lanthanides(III) in the pH range 7-9. It is useful for diagnostic assay manufacturing industry.

Chemical Properties

White powder

Uses

BIS-Tris Propane is a buffer that is useful in the pH 6.3 - 9.5 range. This wide buffering range is due to its two pKa values, 6.8 (pKa1) and 9.0 (pKa2), being so close. Because of the wide buffering range, particularly down to pH 6 - 7, this buffer has been used to enhance the stability or activity of restriction enzymes, compared to Tris buffer (which is a poor buffer below pH 7.5 and has a comparatively large change in pKa with temperature).

Application

BIS-TRIS Propane may be used in the following studies:
As buffer to investigate the influence of anions with varying nucleophilic properties on the autoxidation of oxymyoglobin (MbO2).
Purification of glucose-binding protein from membranes of Sulfolobus solfataricus.
As buffer during GeO2 mineralisation.

Definition

ChEBI: Bis-tris propane is a water-soluble buffer substance used for the preparation of the biochemical and biological buffer solutions; pKa = 6.8 at 20 ℃. It has a role as a buffer. It is functionally related to a member of tris.

General Description

Precautions

This trihydroxyamine analog, also known as bis-tris propane, presents as a white to almost white crystalline powder. Store in a cool and dark place. 1,3-Bis[tris(hydroxymethyl)methylamino]propane is known to be incompatible with oxidizing agents and should not be handled in their vicinity.

Spectrum Detail

Well-known Reagent Company Product Information

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