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Butyryl chloride

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Butyryl chloride Basic information
Butyryl chloride Chemical Properties
  • Melting point:−89 °C(lit.)
  • Boiling point:102 °C(lit.)
  • Density 1.026 g/mL at 25 °C(lit.)
  • vapor density 3.7 (vs air)
  • vapor pressure 39 hPa (20 °C)
  • refractive index n20/D 1.412(lit.)
  • RTECS EM0595000
  • Flash point:71 °F
  • storage temp. Flammables area
  • solubility Miscible with ether.
  • form Liquid
  • color Clear slightly yellow
  • explosive limit2.5-7.3%(V)
  • Water Solubility decomposes
  • FreezingPoint -89℃
  • Sensitive Moisture Sensitive
  • Merck 14,1598
  • BRN 605395
  • InChIKeyDVECBJCOGJRVPX-UHFFFAOYSA-N
  • CAS DataBase Reference141-75-3(CAS DataBase Reference)
  • NIST Chemistry ReferenceButanoyl chloride(141-75-3)
  • EPA Substance Registry SystemButanoyl chloride (141-75-3)
Safety Information
MSDS
Butyryl chloride Usage And Synthesis
  • Chemical PropertiesButyryl chloride is a colorless to light yellow liquid with a strong pungent odor. It undergoes vigorous hydrolysis with water; decomposes in water; soluble in almost aprotic organic solvents. It is used as an intermediate for organic synthesis for the preparation of pharmaceuticals, agrochemicals, dyes, cellulose esters, and peroxide compounds.
  • UsesButyryl chloride is used as an intermediate for the synthesis of active pharmaceutical ingredients benzoyl peroxide, t-butyl perbenzoate, and benzophenone. It is also used as an acylation reagent. Further, it is used in the preparation of peroxides such as benzoyl peroxide, benzophenone and t-butyl perbenzoate. In addition to this, it is involved in the preparation of chromones and antiproliferative agents.
    Butyryl chloride has been used to esterify wood meal dissolved in the ionic liquid, 1-butyl-3-methylimidazolium chloride.
  • General DescriptionA clear colorless liquid with a sharp odor. Slightly denser than water. Flash point near 20°F. Severely irritates skin, eyes, and mucous membranes. Used to make other chemicals.
  • Air & Water ReactionsHighly flammable. Fumes in air. Decomposes exothermically in water to give corrosive hydrochloric acid.
  • Reactivity ProfileButyryl chloride slowly dissolves in water with decomposition and formation of a weakly acidic solution. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
  • Health HazardExtremely destructive to the mucous membranes, upper respiratory tract, eyes, and skin. Inhalation may cause death as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
  • Fire HazardSpecial Hazards of Combustion Products: Emits toxic fumes of chlorine gas
  • Purification MethodsCheck IR to see if there is a significant peak at 3000-3500 cm-1 (br) for OH. If OH is present then reflux with less than one mole equivalent of SOCl2 for 1hour and distil directly. The fraction boiling between 85-100o is then refractionated at atmospheric pressure. Keep all apparatus free from moisture and store the product in sealed glass ampoules under N2. LACHRYMATORY; handle in a good fume hood. [Hefferich & Schaeffer Org Synth Coll Vol I 147 1941, Beilstein 2 IV 803.]
Butyryl chloride Preparation Products And Raw materials
Butyryl chloride(141-75-3)Related Product Information
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