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Ethacrynic acid

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Ethacrynic acid Basic information
Ethacrynic acid Chemical Properties
  • Melting point:125 °C
  • Boiling point:480.0±45.0 °C(Predicted)
  • Density 1.3562 (estimate)
  • storage temp. -20?C Freezer
  • solubility DMSO: soluble20mg/mL, clear
  • pka3.50(at 25℃)
  • form powder
  • color white to beige
  • Water Solubility Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water.
  • Merck 3717
  • CAS DataBase Reference58-54-8(CAS DataBase Reference)
  • EPA Substance Registry SystemEthacrynic acid (58-54-8)
Safety Information
Ethacrynic acid Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • UsesA diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.
  • DefinitionChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC inhibitor.
  • brand nameEdecrin (Merck).
  • General DescriptionWhite solid.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileEthacrynic acid may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. May react exothermically with acids. Reacts exothermically with all bases both organic (for example, the amines) and inorganic.
  • Fire HazardEthacrynic acid is probably combustible.
  • Veterinary Drugs and TreatmentsEthacrynic acid is a loop diuretic that shares the same indications as furosemide (congestive cardiomyopathy, pulmonary edema, hypercalcuric nephropathy, uremia, as adjunctive therapy in hyperkalemia and, occasionally, as an antihypertensive agent). Its use has been largely supplanted in the armamentarium by furosemide for these indications.
    Ethacrynic acid may be useful in the treatment of nephrogenic diabetes insipidus as it may cause a paradoxical decrease in urine volume. Other uses include the adjunctive treatment of hypercalcemia and to increase the excretion of bromide in the treatment of bromide toxicity.
Ethacrynic acid Preparation Products And Raw materials
Ethacrynic acid(58-54-8)Related Product Information
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  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:400-660-8290 21-61259100-
  • Company Name:Nanjing Chemlin Chemical Co., Ltd
  • Tel:025-83697070
  • Company Name:Chemsky(shanghai)International Co.,Ltd.
  • Tel:021-50135380
  • Company Name:Syntechem Co.,Ltd
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  • Company Name:Sinopharm Chemical Reagent Co,Ltd.
  • Tel:86-21-63210123