Dichloroacetic Acid Methyl Ester is used in the preparation of telechelics and block copolymers through living radical polymerization.
Methyl dichloroacetate may be used:
- in the diastereoselctive synthesis of bicyclic chlorocyclopropane
- as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate
- as reagent during CrCl2-induced olefination of aldehydes
Journal of the American Chemical Society, 90, p. 5307, 1968
DOI: 10.1021/ja01021a065The Journal of Organic Chemistry, 28, p. 1133, 1963
A colorless liquid with an ethereal odor. Combustible. Flash point 176°F. Corrosive to metals and tissue. Used to make other chemicals.
Decomposed by water to dichloroacetic acid, a corrosive material with evolution of heat [USCG, 1999].
Dichloroacetic acid methyl ester produces toxic fumes of phosgene and HCl when heated [USCG, 1999].
Strong irritant to tissue. Forms corrosiveproducts on hydrolysis, keep dry.
Extremely destructive to the eyes, nose, throat, and upper respiratory tract. May be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Special Hazards of Combustion Products: Produces toxic fumes of phosgene and HCl.
Poisonous irritant to
the skin, eyes, and mucous membranes.
Hydrolyzes upon contact with moisture to
form a product corrosive to tissue. See also
DICHLOROACETIC ACID and ESTERS.
Dangerous; when heated to decomposition
it emits hghly toxic fumes of phosgene and
Cl-.
