Trichloroacetic Anhydride is used in organometallic reactions as well as oxadiazole containing 5-lipoxygenase activating protein inhibitors.
Trichloroacetic anhydride can be used as a reagent for the generation of trichloroacetic acid esters and amides; the generation of trichloromethyl heterocycles; and the acylation of electron-rich olefins.
Trichloroacetic anhydride is reported to be an efficient derivatization reagent, since it produces stable derivatives having both a higher mass fragmentation pattern and lesser volatility than derivatives of trifluoroacetic anhydride (TFAA) or heptafluorobutyric anhydride (HFBA). The interaction of thymidine 5′-phosphate with trichloroacetic anhydride in dimethylformamide and acetonitrile in the presence of tertiary amines hs been studied.
Trichloroacetic anhydride should be kept under inert gas; very reactive with water; corrosive.
