Trichloroethanol

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.
Some of its other application include:

• Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.
• Preparation of TCE ester of chlorosulfuric acid.
• Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.

Intermediate, anesthetic.

2,2,2-Trichloroethanol (TCE) is an active metabolite of Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] (T774055), a sedative/hypnotic that increases cerebral blood flow (CBF).

ChEBI: 2,2,2-trichloroethanol is a chloroethanol. It has a role as a mouse metabolite.

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andrectal routes. Human mutation data reported. Explosivereaction with concentrated sodium hydroxide solutions.When heated to decomposition it emits toxic fumes ofClí. Us