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Propionyl chloride

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Propionyl chloride Basic information
Propionyl chloride Chemical Properties
  • Melting point:-94 °C
  • Boiling point:77-79 °C (lit.)
  • Density 1.059 g/mL at 25 °C (lit.)
  • vapor density 3.2 (vs air)
  • vapor pressure 106 hPa (20 °C)
  • refractive index n20/D 1.404(lit.)
  • Flash point:53 °F
  • storage temp. Store below +30°C.
  • form Liquid
  • color Clear
  • PH Range<7.0
  • explosive limit3.6-11.9%(V)
  • Water Solubility REACTS
  • FreezingPoint -94℃
  • Sensitive Moisture Sensitive
  • Merck 14,7828
  • BRN 385632
  • InChIKeyRZWZRACFZGVKFM-UHFFFAOYSA-N
  • CAS DataBase Reference79-03-8(CAS DataBase Reference)
  • NIST Chemistry ReferencePropanoyl chloride(79-03-8)
  • EPA Substance Registry SystemPropanoyl chloride (79-03-8)
Safety Information
  • Hazard Codes F,C
  • Risk Statements 11-14-34-20/22
  • Safety Statements 9-16-26-45
  • RIDADR UN 1815 3/PG 2
  • WGK Germany 1
  • RTECS UG6657000
  • Autoignition Temperature270 °C
  • TSCA Yes
  • HazardClass 3
  • PackingGroup II
  • HS Code 29051900
  • HS Code 29399990
  • Hazardous Substances Data79-03-8(Hazardous Substances Data)
  • ToxicityLD50 orally in Rabbit: 823 mg/kg
MSDS
Propionyl chloride Usage And Synthesis
  • Chemical Propertiesclear liquid
  • UsesChemical intermediate.
    Propionyl chloride can be used as an acylating agent:
    To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.
    For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
    In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.
  • UsesPropionyl chloride is used as an intermediate in the production of agrochemicals and pharmaceuticals. It serves as an intermediate for dyes, textile auxiliaries and peroxide compounds. It acts as a crop protecting agent.
  • General DescriptionA colorless liquid with a pungent odor. Flash point of 50°F. Corrosive and very irritating to skin and eyes. Used to make other chemicals.
  • Air & Water ReactionsHighly flammable. Vigorously reacts with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989].
  • Reactivity ProfileAcid halides, such as Propionyl chloride, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
  • HazardStrong irritant to skin.
  • Health HazardMay cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
  • Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
  • Safety ProfileA corrosive irritant to skin, eyes, and mucous membranes. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Reacts with water or steam to produce toxic and corrosive fumes. Exothermic reaction with diisopropyl ether produces much gas. The reaction may be dangerous if confmed. To fight fire, use CO2, dry chemical; do not use water. When heated to decomposition it emits lughly toxic fumes of Cl-. See also HYDROCHLORIC ACID.
Propionyl chloride Preparation Products And Raw materials
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