ChemicalBook > Product Catalog > API > Digestive system drugs > Liver Disease drugs > Diisopropylamine
Diisopropylamine Chemical Properties
- Melting point:-61 °C
- Boiling point:84 °C(lit.)
- Density 0.722 g/mL at 25 °C(lit.)
- vapor density 3.5 (vs air)
- vapor pressure 50 mm Hg ( 20 °C)
- refractive index n
- Flash point:1.4 °F
- storage temp. Store at RT.
- solubility 100 g/L (20°C)
- form Liquid
- pka11.05(at 25℃)
- color Clear colorless
- PH11.8 (6g/l, H2O, 20℃)
- explosive limit1.1-7.1%(V)
- Water Solubility 100 g/L (20 ºC)
- Merck 14,3196
- BRN 605284
- Exposure limitsNIOSH REL: TWA 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm (adopted).
- Stability:Stable. Flammable. Incompatible with strong oxidizing agents. May react violently with strong acids or oxidizers. Air sensitive.
- CAS DataBase Reference108-18-9(CAS DataBase Reference)
- NIST Chemistry Reference2-Propanamine, N-(1-methylethyl)-(108-18-9)
- EPA Substance Registry SystemDiisopropylamine (108-18-9)
- Hazard Codes F,C
- Risk Statements 11-20/22-34
- Safety Statements 16-26-36/37/39-45
- RIDADR UN 1158 3/PG 2
- WGK Germany 2
- RTECS IM4025000
- Autoignition Temperature599 °F
- Hazard Note Highly Flammable/Corrosive/Harmful
- TSCA Yes
- HS Code 2921 19 99
- HazardClass 3
- PackingGroup II
- Hazardous Substances Data108-18-9(Hazardous Substances Data)
- ToxicityLD50 orally in rats: 0.77 g/kg (Smyth)
Diisopropylamine Usage And Synthesis
- Chemical PropertiesDiisopropylamine is a flammable, strongly alkaline Colorless liquid. Diisopropylamine is soluble in water and alcohol. The odor threshold ranges from 0.017 to 4.2 ppm; the fishlike odor becomes irritating at 100 mg/m3.
- Physical propertiesColorless liquid with an ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 50 μg/m3 (130 ppbv) and 190 μg/m3 (380 ppbv), respectively (Hellman and Small, 1974).
- UsesDiisopropylamine is used as a solvent and in the chemical synthesis of dyes, pharmaceuticals, and other organic syntheses.
- Production MethodsDiisopropylamine is produced by the reaction of diisopropyl alcohol with ammonia (HSDB 1989).
- General DescriptionA clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.
- Air & Water ReactionsHighly flammable. Soluble in water. Sensitive to heat and air.
- Reactivity ProfileDiisopropylamine can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
- Health HazardInhalation of vapors causes irritation, sometimes with nausea and vomiting; can also cause burns to the respiratory system. Ingestion causes irritation of mouth and stomach. Vapor irritates eyes; liquid causes severe burn, like caustic. Contact with skin causes irritation.
- Health HazardIn humans, diisopropylamine is an eye irritant. When exposed to concentrations between 25 and 50 p.p.m., workers complained of disturbances of vision. There were also complaints of nausea and headache. Dermatitis would be expected from prolonged skin exposure (Beard and Noe, 1981).
- Chemical ReactivityReactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
- Industrial usesDiisopropylamine is used as a catalyst and as a stabilizer for mesityl oxide (HSDB 1989). It is also used as an intermediate in the synthesis of dyes, pharmaceuticals and pesticides (e.g. Diallate, Fenamiphos and Triallate).
- Safety ProfileModerately toxic by ingestion and subcutaneous routes. Mildly toxic by inhalation. Mutation data reported. A skin and severe eye irritant. Inhalation of fumes can cause pulmonary edema. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam,foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx See also AMINES.
- Environmental FatePhotolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Reacts with acids forming water-soluble salts.
- MetabolismLittle, if any investigation of the metabolism of short-chain aliphatic amines has been reported and the best that can be done is to suggest some possible metabolic routes. For example the flavin monooxygenase system could produce the hydroxylamine through N-hydroxylation catalyzed by the flavin monooxygenase system (Ziegler 1988). N-hydroxylation can also be induced with the cytochrome P-450 system as can N-dealkylation reactions (Lindeke and Cho 1982). More definitive analysis must await experimental studies.
- Purification MethodsDistil the amine from NaOH, or reflux it three minutes over Na wire or NaH, and distil it into a dry receiver under N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]
Diisopropylamine Preparation Products And Raw materials
- Raw materialsAmmoniaIsopropanolHydrogenIsopropylamineKAOLIN
- Preparation Products1-Boc-4-methylpiperidine-4-carboxylic acid1-(2-ISOCYANO-ETHYL)-4-METHYL-PIPERAZINE5-AMINO-2-METHOXY-3-PICOLINE1,2-BIS(4-PYRIDYL)ETHANE4-(Trifluoromethyl)nicotinic acid2-Fluoro-6-formylpyridine1-(3,4-DICHLOROBENZYL)PIPERAZINE2-Chloro-6-trifluoromethylnicotinic acid2-Chloro-4-iodopyridine-3-carboxaldehyde4-Pyridyl acetone2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID4-BROMO-5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE4-Chloropyridine-3-carboxaldehyde2-Fluoro-5-iodobenzaldehyde2-Chloronicotinic acid2-Methylhexanoic acidEflornithineDIBENZYL DIISOPROPYLPHOSPHORAMIDITE2-(Tributylstannyl)pyrimidine3-Amino-5-phenylpyrazole2,5-DICHLORO-4-FORMYLPYRIDINEN,N-DIISOPROPYLBENZOTHIAZOLE-2-SULFENAMIDE3-BROMO-4-FORMYLPYRIDINE3-FLUOROPYRIDINE-4-BORONIC ACID4-AMINO-2-BUTANOLBIS(DIISOPROPYLAMINO)CHLOROPHOSPHINE1-Boc-piperazine3,4-Dichloropyridine2-Bromo-6-fluorobenzoic acid3-Chloro-4-pyridineboronic acid hydrateTriallate3,4-DIBROMO-5-HYDROXY-5H-FURAN-2-ONECreatinineDIALLATE2-Diisopropylaminoethanol dichlorodihydroxybis(isopropylamine)platinum Pinacidil
- Triethylamine Propylamine Tropine (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane Triacetonamine 2,5-Dimethylpyrrolidine N-ISOPROPYLCYCLOHEXYLAMINE 2,5-DIMETHYL-3-PYRROLINE 3-Carboxy-2,2,5,5-tetraMethylpyrrolidine 1-Oxyl Free Radical Triacetonediamine (+/-)-exo-6-Hydroxytropinone Diisopropylamine Isopropylamine Diallylamine N,N'-Diisopropylcarbodiimide 2,2'-Thiobispropane 1-Methyl-2-pyrrolidinone Diisopropylammonium dichloroacetate
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