Ethyltrimethylsilylacetat

Bezeichnung:Ethyltrimethylsilylacetat

CAS-Nr4071-88-9

Englisch Name:Ethyl (trimethylsilyl)acetate

CBNumberCB7271085

SummenformelC7H16O2Si

Molgewicht160.29

MOL-Datei4071-88-9.mol

Synonyma

Ethyltrimethylsilylacetat

Ethyltrimethylsilylacetat physikalisch-chemischer Eigenschaften

Siedepunkt	156-159 °C (lit.)
Dichte	0.876 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.415(lit.)
Flammpunkt	95 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	sol ethereal and chlorinated solvents; reacts with protic solvents.
Aggregatzustand	clear liquid
Farbe	Colorless to Almost colorless
Wichte	0.876
Wasserlöslichkeit	Decomposition
Hydrolytic Sensitivity	2: reacts with aqueous acid
Sensitive	Moisture Sensitive
BRN	1755902
CAS Datenbank	4071-88-9(CAS DataBase Reference)
NIST chemische Informationen	Ethyl (trimethylsilyl)acetate(4071-88-9)

Sicherheit

R-Sätze:	10
S-Sätze:	16-24/25
RIDADR	UN 3272 3/PG 3
WGK Germany	3
F	10-21
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29319090

Gefahreninformationscode (GHS)

Ethyl (trimethylsilyl)acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
Ethyl trimethylsilylacetate is a clear colorless liquid. It is stable to the usual manipulations, and can be stored in glass containers for years without change of physical and spectral properties.
Verwenden
(silylating agent; source of an ethyl acetate anion equivalent.Ethyl trimethylsilylacetate is reactive to nucleophiles and readily undergoes desilylation reactions with acid or alkali,ethanol, and bromine.
Verwenden
Ethyl trimethylsilylacetate is used in the synthesis of ethyl-2,2-dibromo-2-(trimethylsilyl)acetate and α,β-unsaturated esters. It was also used to silylate the enolizable aldehydes and ketones.
synthetische
ethyl trimethylsilylacetate synthesis: Available by a Reformatsky reaction from ethyl bromoacetate, and by reaction of trimethylsilylmethylmagnesium chloride with ethyl chloroformate. An alternative approach requires the treatment of ethyl acetate with triphenylmethylsodium followed by chlorotrimethylsilane The use of a nitrogen base with ethyl acetate in THF followed by reaction with chlorotrimethylsilane results in a mixture of C- and O-silylation. The use of HMPA as additive in the reaction medium increases the amount of O-silylation to 90%. Similar methods can be used to prepare analogs.
Allgemeine Beschreibung
Reaction of ethyl trimethylsilylacetate (ETSA) with dilute hydrochloric acid, dilute alkali, anhydrous HCl, anhydrous bromine and absolute ethanol has been reported. ETSA undergoes condensation with aromatic aldehydes in the presence of base catalyst to yield β-trimethylsiloxycarboxylates. Lithium ETSA reacts with ketones to yield α,β-unsaturated esters.
läuterung methode
Purify it by distilling ca 10g of reagent through a 15cm, Vigreux column (p 11) and then redistilling it through a 21cm glass helices-packed column [Hauze & Hauser J Am Chem Soc 75 994 1953]. Alternatively, dissolve it in Et2O, wash with H2O, dilute Na2CO3, dry over Na2CO3, evaporate Et2O, and distil it through a column of 15 theoretical plates. [Gold et al. J Am Chem Soc 70 2874 1948, Beilstein 4 IV 3974.]

Ethyl (trimethylsilyl)acetate Upstream-Materialien And Downstream Produkte

Ethyltrimethylsilylacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4071-88-9, Ethyl (trimethylsilyl)acetate Verwandte Suche:

Send Inquriy