Ethyl 4-methoxycinnamate

Bezeichnung:Ethyl 4-methoxycinnamate

CAS-Nr24393-56-4

Englisch Name:Ethyl 4-methoxycinnamate

CBNumberCB5205790

SummenformelC12H14O3

Molgewicht206.24

MOL-Datei24393-56-4.mol

Ethyl 4-methoxycinnamate physikalisch-chemischer Eigenschaften

Schmelzpunkt	49°C
Siedepunkt	187 °C / 15mmHg
Dichte	1.080±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Off-White
Wasserlöslichkeit	insoluble in water
BRN	2210033
LogP	2.650 (est)
NIST chemische Informationen	Ethyl p-methoxycinnamate(24393-56-4)

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26-36/37/39-24/25
WGK Germany	3
HS Code	29189900

Gefahreninformationscode (GHS)

Ethyl 4-methoxycinnamate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White crystalline, soluble in methanol, ethanol, DMSO and other organic solvents, derived from cinnamon.
Verwenden
Ethyl 4-methoxycinnamate is an derivative of 4-methoxycinnamic acid, an antihyperglycemic/hypoglycemic agent that works by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
synthetische
Ethyl 4-methoxycinnamate synthesis: 4-Methoxycinnamic Acid (0.60 g, 3.36 mmol) was dissolved in 10 mL of dry N,N-dimethylformamide (DMF) in a 25-mL, roundbottomed flask. Cesium carbonate (1.65 g, 5.06 mmol) was added followed by iodoethane (1.0 mL, 12.5 mmol). The flask was capped (rubber septum) and the heterogeneous mixture stirred vigorously at 50 °C for one hour. After this time, HCl (1.0 M, 4.0 mL) was added to quench the reaction. The liquid was decanted from any remaining solid and extracted with 3 : 1 hexanes/ethyl acetate (2 x 10 mL). The organic layer was washed with brine (20 mL), dried with MgSO4, filtered, and solvent removed. The remaining oil solidified on standing to form colorless prisms.

Synthesis of ethyl 4-methoxycinnamate
Allgemeine Beschreibung
Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats. It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (<10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.

Ethyl 4-methoxycinnamate Upstream-Materialien And Downstream Produkte

Ethyl 4-methoxycinnamate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

24393-56-4, Ethyl 4-methoxycinnamate Verwandte Suche:

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