Bromessigsäure

Bezeichnung:Bromessigsäure

CAS-Nr79-08-3

Englisch Name:Bromoacetic acid

CBNumberCB7486096

SummenformelC2H3BrO2

Molgewicht138.95

MOL-Datei79-08-3.mol

Synonyma

Bromessigsure

Bromessigsäure

Bromessigsäure physikalisch-chemischer Eigenschaften

Schmelzpunkt	46-49 °C
Siedepunkt	208 °C(lit.)
Dichte	1
Dampfdruck	1 mm Hg @ 550C
Brechungsindex	1.4804 (estimate)
Flammpunkt	>110°C
storage temp.	Store below +30°C.
Löslichkeit	chloroform: soluble10%, clear, colorless
pka	2.69(at 25℃)
Aggregatzustand	Crystalline Mass or Crystalline Powder, Flakes, Crystals and/or Chunks
Farbe	White to yellow
Wasserlöslichkeit	miscible
Sensitive	Light Sensitive & Hygroscopic
Merck	14,1400
BRN	506167
Henry's Law Constant	1.5×10³ mol/(m³Pa) at 25℃, Burkholder et al. (2019)
InChI	1S/C2H3BrO2/c3-1-2(4)5/h1H2,(H,4,5)
InChIKey	KDPAWGWELVVRCH-UHFFFAOYSA-N
SMILES	NC(=O)C=C \|\| OC(=O)CBr
LogP	-2.3 at 22℃
CAS Datenbank	79-08-3(CAS DataBase Reference)
NIST chemische Informationen	Acetic acid, bromo-(79-08-3)
EPA chemische Informationen	Bromoacetic acid (79-08-3)

Sicherheit

Kennzeichnung gefährlicher	T,C,N,Xi,F
R-Sätze:	23/24/25-35-50-40-36/37/38-43-38
S-Sätze:	26-36/37/39-45-61-36-16
RIDADR	UN 1938 8/PG II/III (BROMOACETIC ACID SOLUTION)
RIDADR	UN 3425 8/PG II (BROMOACETIC ACID, SOLID)
WGK Germany	2
RTECS-Nr.	AF5950000
F	3-19-23
Hazard Note	Toxic/Corrosive
TSCA	TSCA listed
HazardClass	8
PackingGroup	II
HS Code	29159000
Speicherklasse	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 2 Oral Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Aquatic Acute 1 Eye Dam. 1 Skin Corr. 1A Skin Sens. 1
Giftige Stoffe Daten	79-08-3(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Bromoacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R35:Verursacht schwere Verätzungen.
R50:Sehr giftig für Wasserorganismen.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Aussehen Eigenschaften
C2H3BrO2; Monobromessigsäure, Monobrommethansäure. Farblose, hygroskopische Kristallmasse, die an feuchter Luft zerfließt. In beliebigen Mengen in Wasser unter stark saurer Reaktion löslich.
Gefahren für Mensch und Umwelt
Giftig beim Einatmen, Verschlucken und Berührung mit der Haut. Verursacht schwere Verätzungen. Starke resorptive Giftwirkung.
Heftige Reaktion mit starken Oxidationsmitteln. Bei thermischer Zersetzung werden giftige und ätzende Gase freigesetzt.
LD₅₀ (oral, Maus) 100 mg/kg
Schutzmaßnahmen und Verhaltensregeln
Schutzhandschuhe als kurzzeitiger Substanzschutz.
Verhalten im Gefahrfall
Vorsichtig trocken aufnehmen. Der Entsorgung zuführen. Mit Wasser nachreinigen.
Wasser Schaum. Entweichende Dämpfe mit Wasser niederschlagen.
Brennbar. Im Brandfall kann Bromwasserstoff enstehen.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen. Abtupfen mit Polyethylenglycol 400.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Viel Wasser trinken lassen. Erbrechen vermeiden (Perforationsgefahr). Sofort Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung sofort entfernen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
In Wasser gelöst vorsichtig mit Natriumhydroxid-Lösung neutralisieren. Dann in wässrige, neutrale Lösemittelabfälle.
Chemische Eigenschaften
WHITE TO LIGHT YELLOW CRYSTALLINE MASS
Verwenden
Bromoacetic acid is mainly used for the N-terminal bromoacylation of resin bound peptides.
It can also be used:
- To synthesize (Z)-2-(cyclooct-4-en-1-yloxy)acetic acid.
- To synthesize α-bromo-phenylacetamide.
- To convert aromatic thiosemicarbazones to thiazolylhydrazones.
Verwenden
Bromoacetic acid is used in organic synthesis and as an alkylating agent. It is also used as a biochemical for proteomics research. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals.
Verwenden
Organic synthesis, abscission of citrus fruit in harvesting.
Allgemeine Beschreibung
Aqueous solution.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Carboxylic acids, such as BROMOACETIC ACID, donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Bromoacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Hazard
Strong irritant to skin and tissue.
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Flammability and Explosibility
Non flammable
Sicherheitsprofil
Poison by ingestion, intraperitoneal, and intravenous routes. Irritating and corrosive to skin and mucous membranes. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.
läuterung methode
Crystallise bromoacetic acid from pet ether (b 40-60o). A diethyl ether solution of it is passed through an alumina column, and the ether is evaporated at room temperature under vacuum. It is best obtained by distillation from a Claisen (flask immersed in an oil bath) fitted with an insulated Vigreux column (p 11) and the fraction b 108-110o/30mm is collected. It is light and moisture sensitive. [Natelson & Gottfried Org Synth Coll Vol III 381 1955, Beilstein 2 IV 526.] LACHRYMATORY and is a skin IRRITANT.

Bromoacetic acid Upstream-Materialien And Downstream Produkte

Bromessigsäure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

79-08-3, Bromoacetic acid Verwandte Suche:

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