tert-Butylbromacetat

Bezeichnung:tert-Butylbromacetat

CAS-Nr5292-43-3

Englisch Name:tert-Butyl bromoacetate

CBNumberCB7853739

SummenformelC6H11BrO2

Molgewicht195.05

MOL-Datei5292-43-3.mol

Synonyma

Tert-butylbromacetat

tert-Butylbromacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	44-47 °C
Siedepunkt	50 °C10 mm Hg(lit.)
Dichte	1.338
Dampfdruck	1.62hPa at 25℃
Brechungsindex	n20/D 1.445(lit.)
Flammpunkt	121 °F
storage temp.	0-6°C
Löslichkeit	Chloroform, Ethyl Acetate (Slightly)
Aggregatzustand	Liquid
Wichte	1.333 (20/4℃)
Farbe	Clear colorless to yellow
Wasserlöslichkeit	Miscible with ethanol, chloroform and ethyl acetate. Immiscible with water.
Sensitive	Lachrymatory
BRN	1753010
InChIKey	BNWCETAHAJSBFG-UHFFFAOYSA-N
CAS Datenbank	5292-43-3(CAS DataBase Reference)
NIST chemische Informationen	Acetic acid, bromo-, 1,1-dimethylethyl ester(5292-43-3)
EPA chemische Informationen	Acetic acid, bromo-, 1,1-dimethylethyl ester (5292-43-3)

Sicherheit

Kennzeichnung gefährlicher	Xi,F
R-Sätze:	10-36/37/38
S-Sätze:	26-24/25-16
RIDADR	UN 1993 3/PG 3
WGK Germany	3
F	19
Hazard Note	Irritant/Flammable/Lachrymatory
TSCA	T
HazardClass	3
PackingGroup	III
HS Code	29159080

Gefahreninformationscode (GHS)

tert-Butyl bromoacetate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
clear colorless to yellow liquid
Verwenden
tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.
Verwenden
tert-Butyl bromoacetate is used as an intermediate in the production of dyes, pharmaceuticals, agrochemicals and in organic compounds. It finds application as an alkylating agent. It plays an important role to prepare (2-oxo-4-vinyl-azetidin-1-yl)-acetic acid tert-butyl ester and in collagenase inhibitors synthesis.
Application
tert-Butyl bromoacetate has been used in the synthesis of:
nitrilotriacetic acid end-functionalized polystyrene by atom transfer radical polymerization
building block for substituted t-butyl acetates
dihydropyranyl prelinker which is useful in polymer-assisted deprotection of oligosacchararides
collagenase inhibitor (S,S,R)-(-)-actinonin It is the starting reagent for the synthesis of N-Oxalylglycine derivatives.
synthetische
Tert-butyl bromoacetate ester was synthesized using bromoacetic acid and isobutylene as raw materials,Amberlyst 15,a strong acidic cation exchange resin,as catalyst,and tert-butanol as modifier.
Allgemeine Beschreibung
tert-Butyl bromoacetate serves as building blocks during the synthesis of model N-substituted oligoglycines (peptoids) containing an N-linked lactoside side-chain.
Flammability and Explosibility
Flammable
Sicherheit(Safety)
Tert-Butyl bromoacetate is a lachrymator. The reagent, reaction and its work-up should be handled in an adequately ventilated fume hood while wearing gloves, safety glasses and laboratory coat.
läuterung methode
Dissolve the ester in Et2O, wash it well with ice cold 10% aqueous K2CO3, dry it over CaCl2, filter and evaporate the Et2O, then fractionate it through a Vigreux column (p 11) in a vacuum. LACHRYMATORY. [Abramovitch et al. J Am Chem Soc 64 2274 1942, Abramovitch & Hauser J Am Chem Soc 65 986 1943, Beilstein 2 III 482.]

tert-Butyl bromoacetate Upstream-Materialien And Downstream Produkte

tert-Butylbromacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5292-43-3, tert-Butyl bromoacetate Verwandte Suche:

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