L-Lysin

Bezeichnung:L-Lysin

CAS-Nr56-87-1

Englisch Name:L-Lysine

CBNumberCB4492106

SummenformelC6H14N2O2

Molgewicht146.19

MOL-Datei56-87-1.mol

Synonyma

L-Lysin

L-Lysin physikalisch-chemischer Eigenschaften

Schmelzpunkt	215 °C (dec.)(lit.)
alpha	D20 +14.6° (c = 6.5); D23 +25.9° (c = 2 in 6.0N HCl)
Siedepunkt	265.81°C (rough estimate)
Dichte	1.1360 (rough estimate)
FEMA	3847 \| L-LYSINE
Brechungsindex	26 ° (C=2, 5mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	H₂O: 0.1 g/mL, clear, colorless
Aggregatzustand	Powder or Crystals
pka	2.16(at 25℃)
Farbe	White to light yellow
PH	9.74
Geruch (Odor)	odorless
Optische Aktivität	[α]20/D +26.0±1.0°, c = 2% in 6 M HCl
Wasserlöslichkeit	Soluble in water. Insoluble in ethanol, ethyl ether, acetone, benzene and common neutral solvent.
Merck	14,5636
JECFA Number	1439
BRN	1722531
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	KDXKERNSBIXSRK-YFKPBYRVSA-N
LogP	-3.05
CAS Datenbank	56-87-1(CAS DataBase Reference)
NIST chemische Informationen	Lysine(56-87-1)
EPA chemische Informationen	Lysine (56-87-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	OL5540000
TSCA	Yes
HS Code	29224110
Giftige Stoffe Daten	56-87-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

L-Lysine Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
See ι-LYSINE MONOCHLORIDE.
Chemische Eigenschaften
White to pale yellow crystalline powder
Chemische Eigenschaften
L-Lysine is an essential amino acid (a protein building block) that cannot be produced by the body from other nutri ents. It helps ensure adequate absorption of calcium and the formation of collagen for bone, cartilage and connective tissue. This compound is odorless.
Occurrence
Some natural food sources for l-lysine include lima beans, kidney beans, potatoes, corn, red meat, fish and milk.
Verwenden
lysine is a skin-conditioning amino acid.
Verwenden
Essential amino acid for human development. Lysine residues are useful in many cellular processes, due to their ability to accept a wide variety of post-translational modifications.
Verwenden
A moderate serotonin antagonist and essential amino acid.
Verwenden
L-Lysine is an essential amino acid used in human nutrition. It plays a vital role in calcium absorption, building muscle protein and recovering from surgery or sports injuries. It is used for the treatment of herpes infections and cold sores. Its derivatives lysine acetylsalicylate is utilized to treat pain as well as to detoxify the body after heroin use. It is an important additive to animal feed. Further, it is used in many foods, especially red meats, fish and dairy products.
synthetische
Produced by fermentation. Also produced by use of continuous ion exchange technology.
Definition
ChEBI: An L-alpha-amino acid; the L-isomer of lysine.
Biotechnologische Produktion
C. glutamicum and, to a lesser extent, E. coli are the main organisms used today for industrial L-lysine production. The first L-producing strains based on C. glutamicum were reported in 1961, and those based on E. coli in 1995. The advantages of using E. coli versus C. glutamicum include the achievement of higher growth rates at higher fermentation temperatures. The formation of lysine is highly influenced by two enzymes, aspartate kinase (AK) and homoserine dehydrogenase (HDH). AK converts aspartate into aspartate semialdehyde, and is highly feedback-inhibited by lysine and threonine. HDH converts aspartate semialdehyde into homoserine, which is an intermediate for the biosynthesis of threonine, methionine, and isoleucine. L-Lysine–producing strains therefore often contain a deregulated AK and/or a reduced activity HDH. Despite the improvement of the flux from aspartate towards lysine, the availability of key metabolites from the central metabolic pathways is also essential. Here the formation of oxaloacetate directly from phosphoenol pyruvate or via pyruvate is essential for the carbon yield as some unnecessary cycles are included. For example, inactivation of the enzyme phosphoenol pyruvate carboxykinase, which catalyzes the reverse reaction from oxaloacetate to phosphoenol pyruvate gave an improvement in lysine formation. By overexpression of pyruvate carboxylase, the conversion yield of glucose to lysine could be increased by 50 %. With a synthetic lysine hyperproducing strain, containing 12 defined modifications from the wild type, a carbon yield of 0.55 g/g and a product titer of 120 g/L over 30 h fermentation could be obtained.
Today, however, the main commercial process for L-lysine remains the fermentation of C. glutamicum. This is performed in fed-batch mode in large-scale fermenters of up to 500 m3 volume, with production capacities in excess of 100,000 tonnes. The commercial manufacturing process has been comprehensively described by Pfefferle.
Aroma threshold values
Detection: 500 ppm
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 3161, 1949 DOI: 10.1021/ja01177a063
Allgemeine Beschreibung
L-Lysine is a basic amino acid.
Sicherheitsprofil
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Veterinary Drugs and Treatments
Lysine may be effective in suppressing FHV-1 infections in cats.
läuterung methode
Crystallise L-lysine from aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2097-2122 1961, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]

L-Lysine Upstream-Materialien And Downstream Produkte

L-Lysin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

56-87-1, L-Lysine Verwandte Suche:

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