Lisinopril Dihydrate

Bezeichnung:Lisinopril Dihydrate

CAS-Nr83915-83-7

Englisch Name:Lisinopril Dihydrate

CBNumberCB3113756

SummenformelC21H33N3O6

Molgewicht423.51

MOL-Datei83915-83-7.mol

Lisinopril Dihydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	148 °C
alpha	25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
Brechungsindex	-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
storage temp.	2-8°C
Löslichkeit	H₂O: ≥10 mg/mL
pka	2.5, 4.0, 6.7, 10.1(at 25℃)
Aggregatzustand	solid
Farbe	white
Merck	14,5516
Stabilität	Hygroscopic
CAS Datenbank	83915-83-7(CAS DataBase Reference)
EPA chemische Informationen	L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) (83915-83-7)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	20/21/22
S-Sätze:	22-24/25-36
WGK Germany	3
RTECS-Nr.	TW3589990
HazardClass	IRRITANT
HS Code	2933995300

Gefahreninformationscode (GHS)

Lisinopril Dihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Lisinopril is an angiotensin converting enzyme inhibitor structurally related to enalaprilat. It is reportedly useful in the management of hypertension and congestive heart failure.
Chemische Eigenschaften
White to Off-White Crystalline Powder
Originator
Merck (USA)
Verwenden
An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril.
Verwenden
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition
ChEBI: Lisinopril dihydrate is a hydrate. It has a role as an antihypertensive agent. It contains a lisinopril.
Trademarks
Prinivil (Merck); Zestril (AstraZeneca).
Allgemeine Beschreibung
Lisinopril, 1-[N²-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is alysine derivative of enalaprilat, the active metabolite ofenalapril. Like all ACE inhibitors, it is an active site-directedinhibitor of the enzyme, with the zinc ion used in an effectivebinding interaction at a stoichiometric ratio of 1:1. The pharmacologicaleffects of lisinopril are similar to those of captopriland enalapril.
Biochem/physiol Actions
Angiotensin converting enzyme (ACE) inhibitor.
Clinical Use
Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.
Veterinary Drugs and Treatments
The principle uses of lisinopril in veterinary medicine at present are as a vasodilator in the treatment of heart failure or hypertension. Recent studies have demonstrated that ACE inhibitors, particularly when used in conjunction with furosemide, do improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. Lisinopril may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and in protein losing nephropathies.
Lisinopril may have advantages over other ACE inhibitors in that it may be dosed once daily and less expensive. Disadvantages are that it is only available in human labeled dosage forms and there is much less published information on its use (efficacy, safety, dosing) in veterinary species.

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