L-Histidine hydrochloride monohydrate

Bezeichnung:L-Histidine hydrochloride monohydrate

CAS-Nr5934-29-2

Englisch Name:L-Histidine hydrochloride monohydrate

CBNumberCB1369616

SummenformelC6H12ClN3O3

Molgewicht209.63

MOL-Datei5934-29-2.mol

L-Histidine hydrochloride monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	254 °C (dec.)(lit.)
alpha	9.9 º (c=11, 6 N HCl)
Dichte	1.49 g/cm3
Dampfdruck	<1 hPa (20 °C)
storage temp.	Store below +30°C.
Löslichkeit	H₂O: 100 mg/mL
Aggregatzustand	Solid
Farbe	White
PH	3.5-4.5 (100g/l, H2O, 20℃)
Säure-Base-Indikators(pH-Indikatoren)	3 - 4 at 105 g/l at 25 °C
Geruch (Odor)	odorless
Optische Aktivität	[α]20/D +9.5±0.5°, c = 5% in 5 M HCl
Wasserlöslichkeit	169.9 g/L (20 ºC)
Merck	14,4720
BRN	4168261
InChIKey	CMXXUDSWGMGYLZ-XRIGFGBMSA-N
LogP	-3.32 at 25℃
CAS Datenbank	5934-29-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	22-24/25-36/37-26
WGK Germany	3
RTECS-Nr.	MS3119000
F	10
TSCA	Yes
HS Code	29332990

Gefahreninformationscode (GHS)

L-Histidine hydrochloride monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystals or cryst. or granular powder
Verwenden
L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method.
Verwenden
L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.
Verwenden
L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis.
Allgemeine Beschreibung
Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^? Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^? portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Biochem/physiol Actions
L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.
läuterung methode
Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.]

L-Histidine hydrochloride monohydrate Upstream-Materialien And Downstream Produkte

L-Histidine hydrochloride monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5934-29-2, L-Histidine hydrochloride monohydrate Verwandte Suche:

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