Asparaginsure

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

L-Aspartic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE KRISTALLE.

• PHYSIKALISCHE GEFAHREN

  Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich. Die trockene Substanz kann durch Verwirbeln, Druckluft, Fließen usw. elektrostatisch aufgeladen werden.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen unter Bildung giftiger Gase mit Stickstoffoxiden. Reagiert sehr heftig mit Oxidationsmitteln.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden, besonders als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen und die Atemwege.

• LECKAGE

  Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel.

• R-Sätze Betriebsanweisung:

  R36:Reizt die Augen.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S22:Staub nicht einatmen.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Beschreibung

  L-Aspartic acid is the L-form of the aspartic acid. It is one of the 20 amino acids that used in the protein synthesis. It is the non-essential amino acids for humans as it can be synthesized in vivo. It is important in the synthesis of other amino acids and some nucleotides, and is a metabolite in the citric acid and urea cycles. In animals, it may be used as a neurotransmitter. It can be chemically synthesize from the diethyl sodium phthalimidomalonate. Currently, almost all the aspartic acids are manufactured in China. Its application include being used as low calorie sweetener (as the part of the aspartame), scale and corrosion inhibitor, and in resins. One of its growing applications is for the manufacturing of biodegradable superabsorbent polymer, polyaspartic acid. It can also be used in fertilizer industry to improve water retention and nitrogen uptake.

• Physikalische Eigenschaften

  Solubility 0.5 (25 ℃) g/100 g H2O, pI 2.98, dissociation constants: pK1 2.1, pK2 3.86 (β-COOH), pK3 9.82    
  

• Chemische Eigenschaften

  Colorless crystals. Soluble in water; insoluble in alcohol and ether. Optically active. dl-aspartic acid.

• Chemische Eigenschaften

  Aspartic acid (abbreviated as Asp or D) is an α-amino acid with the chemical formula HOOCCH(NH₂ )CH₂COOH. The carboxylate anion, salt, or ester of aspartic acid is known as aspartate. The Lisomer of aspartate is one of the 20 proteinogenic amino acids, i.e., the building blocks of proteins. Its codons are GAU and GAC. Aspartic acid is, together with glutamic acid, classified as an acidic amino acid with a pKa of 3.9, however in a peptide the pKa is highly dependent on the local environment. A pKa as high as 14 is not at all uncommon. Aspartate is pervasive in biosynthesis. As with all amino acids, the presence of acid protons depends on the residue's local chemical environment and the pH of the solution.

• Chemische Eigenschaften

  Apartic acid is an aliphatic monoaminodicarboxylic acid (amino acid) and is a well-known constituent of protein. It has a slight acid taste

• Occurrence

  Dietary sources
  Aspartic acid is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans. Aspartic acid is found in :
  Animal sources : luncheon meats, sausage meat, wild game
  Vegetable sources: sprouting seeds, oat flakes, avocado,
  asparagus , young sugarcane, and molasses from sugar beets.
  Chemical synthesis
  Racemic aspartic acid can be synthesized from diethyl sodium phthalimido malonate, (C₆H₄(CO)₂NC(CO₂Et)₂).
  The major disadvantage of the above technique is that equimolar amounts of each enantiomer are made. Using biotechnology it is now possible to use immobilized enzymes to create just one type of enantiomer owing to their stereo specificity. Aspartic acid is made synthetically using ammonium fumarate and aspartase from E.coli, E.coli usually breaks down the aspartic acid as a nitrogen source but using excess amounts of ammonium fumarate a reversal of the enzyme's job is possible, and so aspartic acid is made to very high yields, 98.7 mM from 1 M.

• History

  Aspartic acid was first discovered in 1827 by Plisson, derived from asparagine, which had been isolated from asparagus juice in 1806, by boiling with a base.

• Verwenden

  L-Aspartic acid is used as a component of parenteral and enteral nutrition and as a pharmaceutical ingredient. it is used for cell culture and in manufacturing processes. It is widely utilized for mineral supplementation in the salt form.

• Verwenden

  l-aspartic acid is an amino acid used as a skin-conditioning agent.

• Verwenden

  L-aspartic acid is used as a dietary supplement, it can be blended with minerals to make compounds like potassium aspartate, copper aspartate, manganese aspartate, magnesium aspartate, zinc aspartate and more. Increasing the absorption, and hence utilization potentials, of these minerals via the addition of aspartate induces certain health benefits. Many athletes use L-aspartic acid-based mineral supplements orally to enhance their performance capacities. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. It can help promote a robust metabolism, and is sometimes used to treat fatigue and depression. Aspartic acid is used as a component of parenteral and enteral nutrition. In pharmaceutical agents aspartic acid is used as an ammoniac detoxicating agent, hepar function accelerator and fatigue refresher.

• Definition

  ChEBI: The L-enantiomer of aspartic acid.

• Aroma threshold values

  Detection: 300 ppb

• Allgemeine Beschreibung

  To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

• Hazard

  Low toxicity.

• Biologische Aktivität

  Endogenous NMDA receptor agonist.

• Biochem/physiol Actions

  Principal neurotransmitter for fast synaptic excitation.

• Sicherheitsprofil

  Low toxicity by intraperitoneal route. When heated to decomposition emits toxic fumes of NOx.

• Synthese

  Aspartate is non - essential in mammals, being produced from oxaloacetate by transamination. It can also be generated from ornithine and citrulline in the urea cycle. In plants and microorganisms, aspartate is the precursor to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. The conversion of aspartate to these other amino acids begins with reduction of aspartate to its "semi aldehyde," O₂CCH(NH₂)CH₂CHO. Asparagine is derived from aspartate via trans amidation :
  -O₂CCH(NH₂)CH₂CO₂ - + G C (O)NH₃+ O₂CCH(NH₂)CH₂CONH₃+ + GC(O)O
  (where GC(O)NH₂ and GC(O)OH are glutamine and glutamic acid, respectively).

• Synthese

  Enzymatically, aspartic acid is reversibly synthesized by a transamination reaction between oxaloacetic acid and glutamic acid in the presence of pyridoxal phosphate.

• Lager

  Room temperature

• Forms and nomenclature

  There are two forms or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L - aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "Daspartic acid" are more limited. Where enzymatic synthesis will produce one or the other, most chemical syntheses will produce both forms, "DL-aspartic acid," known as a racemic mixture.

• Other biochemical roles

  Aspartate is also a metabolite in the urea cycle and participates in gluconeogenesis. It carries reducing equivalents in the malateaspartate shuttle, which utilizes the ready inter conversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases. In addition, aspartic acid acts as hydrogen acceptor in a chain of ATP synthase.

L-Aspartic acid Upstream-Materialien And Downstream Produkte

Asparaginsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(1029)Suppliers

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