Tyrosin

Bezeichnung:Tyrosin

CAS-Nr60-18-4

Englisch Name:L-Tyrosine

CBNumberCB1269334

SummenformelC9H11NO3

Molgewicht181.19

MOL-Datei60-18-4.mol

Synonyma

Tyrosin

Tyrosin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (dec.) (lit.)
Siedepunkt	314.29°C (rough estimate)
alpha	-11.65 º (c=5,DIL HCL/H2O 50/50)
Dichte	1.34
FEMA	3736 \| L-TYROSINE
Brechungsindex	-12 ° (C=5, 1mol/L HCl)
Flammpunkt	176 °C
storage temp.	Store below +30°C.
Löslichkeit	1 M HCl: 25 mg/mL
Aggregatzustand	powder
pka	2.2(at 25℃)
Farbe	White to Pale-brown
PH	6.5 (0.1g/l, H2O)
Geruch (Odor)	odorless
Geruchsart	odorless
Optische Aktivität	[α]20/D 11.5±1.0°, c = 4% in 1 M HCl
Wasserlöslichkeit	0.45 g/L (25 ºC)
JECFA Number	1434
Merck	14,9839
BRN	392441
Stabilität	Stable. Incompatible with strong oxidizing agents, strong reducing agents.
InChIKey	OUYCCCASQSFEME-QMMMGPOBSA-N
LogP	0.38
CAS Datenbank	60-18-4(CAS DataBase Reference)
NIST chemische Informationen	Tyrosine(60-18-4)
EPA chemische Informationen	L-Tyrosine (60-18-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-40
S-Sätze:	26-36-37/39-22
WGK Germany	3
RTECS-Nr.	YP2275600
TSCA	Yes
HS Code	29225000
Giftige Stoffe Daten	60-18-4(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: > 5110 mg/kg

Gefahreninformationscode (GHS)

L-Tyrosine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
White to off-white powder
Chemische Eigenschaften
L-Tyrosine is odorless and has a bland taste. L-Tyrosine is a nonessential amino acid, as it is synthesized in the human body from phenylalanine. It is a precursor to epinephrine, norepinephrine and dopamine, three important neurotransmitters.
Occurrence
Reported found in white bread, macaroni, egg noodles, corn flakes, corn grits, oatmeal, wheat bran, wheat flakes, shredded wheat, barley brown rice, rye flour, whole grain wheat flour, buttermilk, blue cheese, cheddar cheese, cottage cheese, cream cheese, parmesan cheese, bacon, cured ham, frankfurters, pork sausage, canned red kidney beans, canned sweet corn, canned peas, canned lima beans, canned potatoes, almonds, cashews, peanuts, dates, beef, lamb, veal, chicken and turkey.
Verwenden
L-Tyrosine is one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
Verwenden
tyrosine is an amino acid. Cutaneous applications may produce an extra reserve of tyrosine in the skin, assisting or “activating” melanin synthesis. This in turn should increase and prolong the effect of the tanning process. Tyrosine’s effect is improved if the product contains vitamin B (riboflavin) plus an additional compound referred to chemically as ATP (adenosine triphosphate). experiments conducted with l-tyrosine in the form of watersoluble derivatives found that it penetrates the epidermis to the basal layer where the melanocytes are located. It is used in suntan accelerators and in skin-bronzing cosmetics to accelerate the tanning process.
Verwenden
neuromuscular blocker
Definition
ChEBI: An optically active form of tyrosine having L-configuration.
Aroma threshold values
Detection: >10 ppm
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 28, p. 673, 1980 DOI: 10.1248/cpb.28.673
Journal of the American Chemical Society, 100, p. 3559, 1978 DOI: 10.1021/ja00479a044
Tetrahedron Letters, 29, p. 3591, 1988 DOI: 10.1016/0040-4039(88)85301-2
Biochem/physiol Actions
L-Tyrosine consists of a polar side chain and is a non-essential amino acid. It is utilized by cells to synthesize proteins that are involved in signal transduction. L-Tyrosine acts as a receiver of phosphate groups that are transferred by kinases.
Sicherheitsprofil
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
läuterung methode
Likely impurities are L-cysteine and the ammonium salt. L-Tyrosine is dissolved in dilute ammonia, then crystallised by adding dilute acetic acid to pH 5. Also, crystallise it from H2O or EtOH/H2O, and dry it at room temperature in a vacuum over P2O5. It sublimes at 235-240o/0.03mm with 99.2% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Albert Biochem J 50 690 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2348-2366 1961, Beilstein 14 IV 2264.]

L-Tyrosine Upstream-Materialien And Downstream Produkte

Tyrosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

60-18-4, L-Tyrosine Verwandte Suche:

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