Pidolinsure

Bezeichnung:Pidolinsure

CAS-Nr98-79-3

Englisch Name:L-Pyroglutamic acid

CBNumberCB9197008

SummenformelC5H7NO3

Molgewicht129.11

MOL-Datei98-79-3.mol

Synonyma

Pidolinsure

Pidolinsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	160-163 °C(lit.)
Siedepunkt	239.15°C (rough estimate)
alpha	-27.5 º (c=10, 1 N NaOH)
Dichte	1.3816 (rough estimate)
Dampfdruck	0.002Pa at 25℃
Brechungsindex	-10 ° (C=5, H2O)
storage temp.	2-8°C
Löslichkeit	H₂O: 1 M at 20 °C, clear, colorless
Aggregatzustand	Crystalline Powder
pka	3.32(at 25℃)
Farbe	White to off-white
PH	1.7 (50g/l, H2O, 20℃)
Geruch (Odor)	wh. crystal, odorless, sl. acidic taste
Optische Aktivität	[α]20/D 10.5±1°, c = 5% in H2O
Wasserlöslichkeit	10-15 g/100 mL (20 ºC)
Merck	14,8001
BRN	82132
Stabilität	Stable. Incompatible with bases, acids, strong oxidizing agents.
LogP	-1.233 at 20℃
CAS Datenbank	98-79-3(CAS DataBase Reference)
NIST chemische Informationen	Pidolic acid(98-79-3)
EPA chemische Informationen	5-Oxo-L-proline (98-79-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	TW3710000
F	21
TSCA	Yes
HazardClass	IRRITANT
HS Code	29337900

Gefahreninformationscode (GHS)

L-Pyroglutamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
L-pyroglutamic acid has its scientific name being L-2-pyrrolidone-5-carboxylic acid. Precipitation from ethanol and petroleum ether mixture were colorless orthorhombic bipyramid crystals with the melting temperature being 162~163 °C. It is soluble in water, alcohol, acetone and acetic acid, slightly soluble in ethyl acetate, and insoluble in ether. Specific rotation-11.9 ° (c = 2, H2O). It is produced from 42% aqueous solution of glutamic acid which subjects to heating dehydration, concentration, crystallization, washing and drying to obtain L-pyroglutamic acid.
Verwenden
In the resolution of racemic amines.
Verwenden
L-Pyroglutamic acid is an amino acid that is used in the synthesis of peptides. It has also been observed to convert when placed at the N-terminus in vivo to create IgG2 antibodies.
Verwenden
A building block for pharmaceuticals and asymmetric synthesis
Definition
ChEBI: An optically active form of 5-oxoproline having L-configuration.
Flammability and Explosibility
Not classified
läuterung methode
Crystallise S-pyroglutamic acid by dissolving it in boiling EtOH (20g in 100mL), cooling and after a few minutes additing pet ether (b 40-60o, 120mL), then after 5 minutes adding a further 120mL, and coThis has m 155.5-157.5o and [] D -11.4o (c 4.4, H2O) [Hardy Synthesis 290 1978, Pellegata et al. Synthesis 614 1978]. The NH4 salt has m 184-186o (from EtOH). [Beilstein 22/6 V 7.]

L-Pyroglutamic acid Upstream-Materialien And Downstream Produkte

Pidolinsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

98-79-3, L-Pyroglutamic acid Verwandte Suche:

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