Fumarsure Produkt Beschreibung

Fumaric acid Struktur
  • CAS-Nr.110-17-8
  • Bezeichnung:Fumarsure
  • Englisch Name:Fumaric acid
  • Synonyma:Fumarsure;(E)-2-Butendisäure<BR>trans-1,2-Ethylendicarbonsäure
    FA;TMEDA;U-1149;fumaric;NSC-2752;FEMA 2488;Fumarsure;FUMARSAEURE;boleticacid;FUMARIC ACID
  • CBNumber:CB5852804
  • Summenformel:C4H4O4
  • Molgewicht:116.07
  • MOL-Datei:110-17-8.mol
Fumarsure physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :298-300 °C (subl.)(lit.)
  • Siedepunkt: :137.07°C (rough estimate)
  • Dichte :1.62
  • Dampfdruck :1.7 mm Hg ( 165 °C)
  • FEMA  :2488 | FUMARIC ACID
  • Brechungsindex :1.5260 (estimate)
  • Flammpunkt: :230 °C
  • storage temp.  :Store below +30°C.
  • Löslichkeit :95% ethanol: soluble0.46g/10 mL, clear, colorless
  • Aggregatzustand :Fine Crystalline Powder
  • pka :3.02, 4.38(at 25℃)
  • Farbe :White
  • PH :2.1 (4.9g/l, H2O, 20℃)
  • Explosionsgrenze :40%
  • Wasserlöslichkeit :0.63 g/100 mL (25 ºC)
  • Merck  :14,4287
  • BRN  :605763
  • Stabilität: :Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
  • CAS Datenbank :110-17-8(CAS DataBase Reference)
  • NIST chemische Informationen :Fumaric acid(110-17-8)
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :36
  • S-Sätze: :26
  • RIDADR  :UN 9126
  • WGK Germany  :1
  • RTECS-Nr. :LS9625000
  • Selbstentzündungstemperatur :375 °C
  • TSCA  :Yes
  • HS Code  :29171900
  • Giftige Stoffe Daten :110-17-8(Hazardous Substances Data)
  • Toxizität :LD50 orally in Rabbit: 9300 mg/kg LD50 dermal Rabbit 20000 mg/kg

Fumaric acid Chemische Eigenschaften,Einsatz,Produktion Methoden

  • Beschreibung Fumaric acid is an important kind of organic chemical raw materials as well as the intermediate of fine chemical products. Meanwhile, it is also an important kind of derivatives of maleic anhydride, being widely used in food, coatings, resins and plasticizers. In the food industry, fumaric acid, used as souring agent, can be applied to soft drinks, western-style wine, cold drinks, fruit juice concentrate, canned fruit, pickles and ice cream. As an acidic substance used as solid beverage gas production agent, it has excellent bubble durability with delicate product organization.
    Fumaric acid has been used as a food acidulant since 1946. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. Chemically it is an unsaturated dicarbonic acid and is part of the citric acid cycle.
    Fumaric acid is a common food additive included in many processed foods to keep them stable and to add tartness. The substance has a more sour flavor than citric acid, another common food additive. Fumaric acid occurs naturally in fumitory, bolete mushrooms, lichen and Iceland moss. As an additive, fumaric acid is produced synthetically, mainly from malic acid from apples. Fumaric acid as an additive is regulated under the Codex Alimentarius General Standard for Food Additives (GSFA), a collection of internationally recognized standards.The U.S. Food and Drug Administration considers it safe.
  • Chemische Eigenschaften Fumaric acid is naturally presented in Corydalis, mushrooms and fresh beef. Product precipitated from the water is monoclinic needle-like, prismatic or leaf-like white crystalline or crystalline powder. It is odorless with a special and strong sour, which is about 1.5 times that of the citric acid. It has a melting point 287 ° C, the boiling point of 290 ° C with subjecting to sublimation at temperature above 200 ° C. When being heated to 230 ° C, it will lose water and become maleic anhydride. Its co-boiling with water can produce DL-malic acid. It is soluble in ethanol, slightly soluble in water and ether, but insoluble in chloroform. The pH value of the 3% aqueous solution is 2.0 to 2.5 with a strong buffering performance, in order to maintain the pH of the aqueous solution at around 3.0. This product is non-toxic; rat-oral LD50: 8000mg/kg.
  • Chemische Eigenschaften Fumaric acid is a colorless to white, odorless crystalline powder. Fruity-acidic taste.
  • Verwenden fumaric acid is used to add fragrance to products and to decrease product pH. It can also help keep the pH stable. It is generally used in cleansers. Fumaric acid is naturally occurring in plants, such as lichen and Iceland moss, and in animals. For example, the skin produces fumaric acid when exposed to light. It can also F be synthetically manufactured.
  • Verwenden Fumaric Acid is an acidulant that is a nonhygroscopic, strong acid of poor solubility. it has a solubility of 0.63 g in 100 ml of distilled water at 25°c. it dissolves slowly in cold water, but if mixed with dioctyl sodium sulfosuccinate its solubility improves. the solubility rate also increases with smaller particle size. a quantity of 0.317 kg of can replace 0.453 kg of citric acid. it is used in dry mixes such as desserts, pie fillings, and candy. it is used in dry bever- age mixes because it is storage stable, free flowing, and nonhygro- scopic. it functions as a synergistic antioxidant with bha and bht in oiland lard-base products. in gelatin desserts, it improves the flavor stability and increases shelf life and gel strength.
  • Verwenden 1. Fumaric acid is used for the production of unsaturated polyester resin. This kind of resin is characterized by excellent resistance to chemical corrosion as well as heat resistance; the copolymer of fumaric acid and vinyl acetate is a kind of excellent adhesive. Its copolymer with styrene copolymer is the raw material for the manufacture of glass fiber. The plasticizer of the fumaric acid is non-toxic and can be applied to the vinyl acetate latex contact with food. This product is the intermediate of pharmaceutical and optical bleaching agents and other fine chemicals. Neutralization of fumaric acid with sodium carbonate can generate sodium fumarate ([17013-01-3]), and then replaced with ferrous sulfate to get iron fumarate, being the drug Fersamal used for the treatment of small red blood cell anemic. The product, as a food additive-sourness agent, used in soft drinks, fruit sugar, jelly, ice cream with most of them used in combination with sourness agent, citric acid. The monosidum salt made from the reaction between fumaric acid and sodium hydroxide can also used as sour seasoning, also used as the intermediate of synthetic resin and mordant.
    2. Fumaric acid is included in many dairy-based products. These include dairy drinks such as chocolate milk, cocoa, eggnog, condensed milk and whey protein beverages. It also may be added to clotted cream, milk and cream powders and milk and cream analogues (substitutes). Fumaric acid is added to cheese products, including processed cheese and cheese substitutes. Dairy-based desserts, such as pudding, flavored yogurt, sherbet and sorbet may include fumaric acid as well. Dairy fat spreads and blended spreads can include fumaric acid, and so can preserved eggs and egg-based desserts such as custard.
    3. Some processed and packaged foods have fumaric acid added to them to help stabilize them and enhance their flavor. For example, many processed meats, such as bacon and canned meats, have added fumaric acid. Frozen seafood, smoked meats and the edible casings around sausages might also have fumaric acid added to them. Fermented, canned, dried and processed fruits and vegetables can contain the food additive as well. Rice cakes and other precooked rice foods, dried or preserved eggs, mustard, vinegar, cider, wine and other alcoholic beverages are additional examples of foods that might contain fumaric acid.
  • Verwenden Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.
  • Definition ChEBI: A butenedioic acid in which the C2C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.
  • Biotechnologische Produktion Currently, fumaric acid is mainly manufactured by chemical synthesis via the precursor maleic acid, which is produced using either benzene or n-butane via catalytic oxidation. However, there are enzymatic and fermentative production routes for fumaric acid. Prior to the advent of inexpensive petroleumbased chemistry, fumaric acid was produced commercially by fermentation using organisms of the genus Rhizopus with an annual production of 4,000 metric tons . Product concentrations from 30 to 130 g.L-1 with yields from 0.3 to 1.0 g of fumaric acid per gram of glucose and productivities of 0.46–2.0 g.L-1.h-1 have been reported growing on glucose .
    In recent years, new approaches using metabolic engineering have been studied. For example, fumaric acid concentrations of 28.2 g.L-1 with a productivity of 0.448 g.L-1.h-1 have been reached in fed-batch cultivation of a genetic modified E. coli . To achieve this result, eight modifications have been implemented.
    Fumaric acid could be alternatively synthesized by an enzymatic process starting from maleic acid as in the chemical synthesis. By whole-cell biocatalysis of the Pseudomonas alcaligenes strain XD-1, a yield of 0.698 g of fumaric acid per gram of maleic acid and a production rate of 6.98 g.L-1.h-1 have been reached . The process has been optimized. The formation of the byproduct malic acid was avoided due to an inactivation of fumarase by a heat treatment of the cells beforehand. Finally, a yield of 0.95 g fumaric acid per gram maleic acid and a production rate of 14.25 g.L-1.h-1 have been observed.
  • Allgemeine Beschreibung A colorless crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Combustible, though may be difficult to ignite. Used to make paints and plastics, in food processing and preservation, and for other uses.
  • PHYSIKALISCHE GEFAHREN Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.
  • Air & Water Reaktionen Slightly soluble in water.
  • CHEMISCHE GEFAHREN Beim Verbrennen Bildung von reizenden Rauchen mit Maleinsäureanhydrid.
  • ARBEITSPLATZGRENZWERTE TLV nicht festgelegt (ACGIH 2005).
    MAK nicht festgelegt (DFG 2005).
  • Reaktivität anzeigen Fumaric acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Fumaric acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Partial carbonization and formation of maleic anhydride occur at 446° F (open vessel).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Verschlucken.
  • INHALATIONSGEFAHREN Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
  • Health Hazard Inhalation of dust may cause respiratory irritation. Compound is non-toxic when ingested. Prolonged contact with eyes or skin may cause irritation.
    Die Substanz reizt die Augen, die Haut und die Atemwege.
  • LECKAGE Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
  • R-Sätze Betriebsanweisung: R36:Reizt die Augen.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Aussehen Eigenschaften C4H4O4; trans-Butendisäure. Farbloses, praktisch geruchloses Pulver.
  • Sicherheitsprofil Poison by intraperitoneal route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Gefahren für Mensch und Umwelt Reizt die Augen und Atmungsorgane.
    Nicht mit starken Oxidationsmitteln in Berührung bringen.
    LD50 (oral, Ratte): 10700 mg/kg.
  • Schutzmaßnahmen und Verhaltensregeln Geeignete Schutzhandschuhe als kurzzeitiger Staubschutz.
  • mögliche Exposition Fumaric acid is used in production of resins, polyesters, plasticizers, and alkyl surface coatings; as a food additive; as an antioxidant in resins; to make dyes.
  • Verhalten im Gefahrfall Vorsichtig trocken aufnehmen. Der Entsorgung zuführen.
    Kohlendioxid, Wasser, Schaum, Pulver.
    Brennbar. Gefahr der Staubexplosion.
  • Erste Hilfe Nach Hautkontakt: Mit reichlich Wasser abwaschen.
    Nach Augenkontakt: Mit reichlich Wasser bei geöfnnetem Lidspalt mindestens 10 Minuten ausspülen. Augenarzt hinzuziehen.
    Nach Einatmen: Frischluft.
    Nach Verschlucken: Reichlich Wasser trinken. Erbrechen auslösen. Arzt hinzuziehen.
    Nach Kleidungskontakt: Kontaminierte Kleidung sofort entfernen.
    Ersthelfer: siehe gesonderten Anschlag

  • Sachgerechte Entsorgung Als feste Laborchemikalienabfälle.
  • Erste Hilfe If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
  • läuterung methode Crystallise it from hot M HCl or water and dry it at 100o. [Beilstein 2 IV 2202.]
  • Inkompatibilitäten Dust cloud from powder or granular form mixed with air can explode. Incompatible with oxidi zers (chlorates, nitrates, peroxides, permanganates, perchlo rates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, sulfuric acid, caustics, ammonia, amines, isocyanates, alkylene oxi des; epichlorohydrin. Decomposes above 350℃ forming toxic fumes of maleic anhydride.
  • Waste disposal Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regula tions must be observed.
Fumaric acid Upstream-Materialien And Downstream Produkte
Downstream Produkte
Fumarsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
  • Firmenname:Shanghai Kangtuo Chemical Co., Ltd.
  • Telefon:021-69185553 69185552
  • Fax:021-69186006
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  • Land:China
  • Produktkatalog:5177
  • Edge Rate:55
  • Firmenname:Hefei TNJ Chemical Industry Co.,Ltd.
  • Telefon:+86 (551) 65418695 65418696
  • Fax:+86 (551) 65418697
  • E-Mail:info@tnjchem.com
  • Land:China
  • Produktkatalog:1944
  • Edge Rate:62
  • Firmenname:Shanghai Boyle Chemical Co., Ltd.
  • Telefon:Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
  • Fax:+86-21-57758967
  • E-Mail:sales@boylechem.com
  • Land:China
  • Produktkatalog:2220
  • Edge Rate:55
  • Firmenname:J & K SCIENTIFIC LTD.
  • Telefon:400-666-7788 +86-10-82848833
  • Fax:+86-10-82849933
  • E-Mail:jkinfo@jkchemical.com;market6@jkchemical.com
  • Land:China
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  • Edge Rate:76
  • Firmenname:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Telefon:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
  • Fax:+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)
  • E-Mail:sh@meryer.com
  • Land:China
  • Produktkatalog:40399
  • Edge Rate:62
110-17-8, Fumaric acid Verwandte Suche:
  • Butenedioic acid, (E)-
  • femanumber:2488
  • fumaric
  • Kyselina fumarova
  • kyselinafumarova
  • kyselinafumarova(czech)
  • NSC-2752
  • trans-1,2-ethenedicarboxylicacid
  • trans-2-ethenedicarboxylicacid
  • (e)-1,2-ethenedicarboxylic acid
  • (E)-2-Butenedioic acid
  • FA
  • FEMA 2488
  • FUMARIC ACID, 99+%
  • FUMARIC ACID 99.5-100.5% FCC GR
  • Fumaric Acid FCC NF, 99%
  • FumaricAcidForMicroscopy
  • Fumaric acid, 99.5%
  • 2-Butenedioic acid (2E)-
  • 1-(E)-butenedioic acid
  • E-butenedioic acid
  • FuMaric acid 0
  • Fumaric acid >=99.0% (T)
  • Fumaric acid tested according to USP/NF
  • Fumaric acid Vetec(TM) reagent grade, 99%
  • Fumaric acid、Trans-butenedioic acid
  • Fumaric acid ,anhydrous, free-flowing
  • acidefumarique
  • Allomaleic acid
  • allomaleicacid
  • Boletic acid
  • boleticacid
  • trans-Ethylene-1,2-dicarboxylicacid
  • Tumaric acid
  • U-1149
  • USAF ek-p-583
  • usafek-p-583