93102-05-7

50-00-0

53215-95-5

93102-05-7

N-[(Trimethylsilyl)methyl]benzylamine (Intermediate P15, 28.588 g, 144.89 mmol) was added dropwise to the formaldehyde solution (37%, 16.816 g, 207.19 mmol) at 0 °C. Subsequently, solid potassium carbonate (16.182 g, 115.91 mmol) was added to the reaction mixture and stirred continuously for 2 hours at room temperature. After completion of the reaction, water (50 mL) was added for dilution and the mixture was extracted with ether (2 x 50 mL). The organic layer was subsequently washed with brine and dried with anhydrous sodium sulfate. Finally, the solvent and desiccant were removed by reduced pressure distillation to afford 33.551 g of the yellow oily target product N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine in 97.5% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.35-7.18 (m, 5H), 3.99 (s, 2H), 3.75 (s, 2H), 3.22 (s, 3H), 2.18 (s, 2H), 0.13 (s, 9H).