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120-51-4

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Identification

Name
Benzyl benzoate
CAS
120-51-4
Synonyms
ASCABIN
ASCABIOL
ASCABIOL(R)
BENYLATE(R)
BENZOIC ACID BENZYL ESTER
BENZOIC ACID PHENYLMETHYL ESTER
BENZYL BENZENECARBOXYLATE
BENZYL BENZOATE
BENZYLIS BENZOAS
BENZYL PHENYL FORMATE
FEMA 2138
VANZOATE(R)
VENZONATE(R)
Benylate
Benzyl alcohol benzoic ester
Benzyl ester
benzylalcoholbenzoicester
Benzylester kyseliny benzoove
benzylesterkyselinybenzoove
Benzylets
EINECS(EC#)
204-402-9
Molecular Formula
C14H12O2
MDL Number
MFCD00003075
Molecular Weight
212.24
MOL File
120-51-4.mol

Chemical Properties

Appearance
Colourless oily liquid with pleasant aromatic odour
Melting point 
18 °C
mp 
18 °C
Boiling point 
323-324 °C(lit.)

bp 
323-324 °C(lit.)

density 
1.118 g/mL at 20 °C(lit.)

vapor pressure 
1 mm Hg ( 125 °C)

FEMA 
2138
refractive index 
n20/D 1.568(lit.)

Fp 
298 °F

storage temp. 
2-8°C
solubility 
Miscible with ethanol, alcohol, chloroform, ether, oils.
form 
Liquid
color 
Clear colorless
Stability:
Stable. Substances to be avoided include strong oxidizing agents. Combustible.
Water Solubility 
practically insoluble
Merck 
14,1127
BRN 
2049280
Contact allergens
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.
InChIKey
SESFRYSPDFLNCH-UHFFFAOYSA-N
Uses
benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
CAS DataBase Reference
120-51-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzyl Benzoate(120-51-4)
EPA Substance Registry System
120-51-4(EPA Substance)

Hazard Information

Chemical Properties
Colourless oily liquid with pleasant aromatic odour
Uses
antiarteriosclerotic, hypolipaemic, hepatoprotectant
Uses
Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions.
Uses
Used to kill lice and the mites responsible for the skin condition scabies.
Uses
As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.
Hazard
Irritant to eyes, skin.

Safety Data

Hazard Codes 
Xn
Risk Statements 
R22:Harmful if swallowed.
Safety Statements 
S25:Avoid contact with eyes .
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
2

RTECS 
DG4200000

TSCA 
Yes
HazardClass 
9
HS Code 
29163100
Hazardous Substances Data
120-51-4(Hazardous Substances Data)
Toxicity
LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Benzyl benzoate (BnBzO) is a mediation and insect repellent. It is one of the older preparation used to treat scabies which is a skin infections caused by the mite scarcoptes scabiei since it is lethal to the mite. It is capable of killing the mite in 5 minutes. It can also be used for the treatment of lice infestation of the head and the body. Its mechanism of action is through exerting toxic effect on the nervous system of the insects, further causing its death. It is also toxic to mite ova through an unknown mechanism. It can also be used as a repellent for chiggers, ticks, and mosquitoes as well as a dye carrier, solvent of cellulose derivatives, plasticizer, and a fixative.
Chemical Properties
Benzyl benzoate is a clear, colorless, oily liquid with a light, balsamic odor reminiscent of almond and a sharp, pungent taste. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃ it exists as clear, colorless crystals.
Uses
Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions.
Benzyl benzoate is a benzyl compound that can be synthesized by reacting benzyl chloride with sodium benzoate in the presence of tetrabutylaramonium iodide. It has been used to:
Prepare benzyl alcohol/benzyl benzoate (BABB) solution employed for enhancing the tissue transparency during the whole-mount immunostaining BABB method.
Study its ability to induce an olfactory response in the third instar larvae of Drosophila melanogaster.
Prepare Spalteholz fluid in combination with methyl salicylate, employed during LSFM (light sheet fluorescence microscopy) imaging.
Preparation
Benzyl benzoate is a constituent of Peru balsam and occurs naturally in certain plant species. Commercially, benzyl benzoate is produced synthetically by the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by the reaction of sodium benzylate with benzaldehyde.
toxicity
In man, benzyl benzoate was a skin sensitizer and caused gastro-intestinal effects in an infant. It was of moderate to low acute oral toxicity in a range of laboratory animal species and of low acute dermal toxicity in rabbits. Central nervous system effects were induced in several species given single doses orally or dermally. Repeated skin applications caused degenerative changes in various organs (including the liver, spleen and testes) of rabbits. No effects were seen in reproductive studies involving repeated oral administration to rats during pregnancy and lactation. Benzyl benzoate gave no evidence of mutagenicity in an Ames bacterial assay. It was a mild skin irritant in rabbits.
References
https://www.drugbank.ca/drugs/DB00676
https://en.wikipedia.org/wiki/Benzyl_benzoate

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