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63-92-3

Supplier Related Products Identification Chemical Properties Safety Data Hazard Information Material Safety Data Sheet(MSDS) Spectrum Detail Well-known Reagent Company Product Information

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Identification

Name
Phenoxybenzamine hydrochloride
CAS
63-92-3
Synonyms
2-(n-benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
BENZENE METHANAMINE HYDROCHLORIDE
DIBENZYLINE HYDROCHLORIDE
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride
N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)BENZYLAMINE HYDROCHLORIDE
N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE
PHENOXYBENZAMINE
PHENOXYBENZAMINE HCL
PHENOXYBENZAMINE HYDROCHLORIDE
bensylytnen
benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride
dibenzyran
fenossibenzamina
fenoxybenzamin
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzenemethanaminhydrochlo
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzylaminhydrochloride
n-2-phenoxyisopropyl-n-benzyl-chloroethylaminehydrochloride
n-benzyl-n-phenoxyisopropyl-beta-chlorethylaminehydrochloride
nci-c01661
n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride
EINECS(EC#)
200-569-7
Molecular Formula
C12H12ClNO
MDL Number
MFCD00599580
Molecular Weight
221.68
MOL File
63-92-3.mol

Chemical Properties

Appearance
White crystalline solid or powder. Odorless.
mp 
137.5°C
storage temp. 
2-8°C

solubility 
H2O: slightly soluble

form 
powder

color 
white

Water Solubility 
<0.01 g/100 mL at 18.5 ºC
Merck 
7256
CAS DataBase Reference
63-92-3(CAS DataBase Reference)
EPA Substance Registry System
63-92-3(EPA Substance)

Safety Data

Hazard Codes 
Xn
Risk Statements 
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
Safety Statements 
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
WGK Germany 
3

RTECS 
DP3750000

HS Code 
2922299000
Safety Profile
Confumed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal,intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl-.

Hazard Information

General Description
White crystalline powder. Melting point 137.5-140°C. Used as an antihypertensive drug.
Air & Water Reactions
Light sensitive and may be sensitive to exposure to air . Insoluble in water.
Potential Exposure
Used as an antihypertensive drug
Fire Hazard
Flash point data are not available for this chemical, but PHENOXYBENZAMINE HYDROCHLORIDE is probably combustible.
First aid
Move victim to fresh air. Call 911 or emergency medical service. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a oneway valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed.
Shipping
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Sensitive upon exposure to light and air. May form unstable and explosive peroxides upon standing.
Waste Disposal
Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

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